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Ryabov, Andrey, Cygelnikov, Stansilav, Pikin, Oleg, Aleksandrov, Oleg, Bagrov, Vladimir, Gusev, Aleksandr, Toneev, Evgeniy, Surkova, Viktoriya, Dotdaev, Aznaur. (1405). Primary Leiomyosarcoma of the Superior Vena Cava: A Rare Case Report. سامانه مدیریت نشریات علمی, 51(7), 523-527. doi: 10.30476/ijms.2026.109892.4532
Andrey Ryabov; Stansilav Cygelnikov; Oleg Pikin; Oleg Aleksandrov; Vladimir Bagrov; Aleksandr Gusev; Evgeniy Toneev; Viktoriya Surkova; Aznaur Dotdaev. "Primary Leiomyosarcoma of the Superior Vena Cava: A Rare Case Report". سامانه مدیریت نشریات علمی, 51, 7, 1405, 523-527. doi: 10.30476/ijms.2026.109892.4532
Ryabov, Andrey, Cygelnikov, Stansilav, Pikin, Oleg, Aleksandrov, Oleg, Bagrov, Vladimir, Gusev, Aleksandr, Toneev, Evgeniy, Surkova, Viktoriya, Dotdaev, Aznaur. (1405). 'Primary Leiomyosarcoma of the Superior Vena Cava: A Rare Case Report', سامانه مدیریت نشریات علمی, 51(7), pp. 523-527. doi: 10.30476/ijms.2026.109892.4532
Ryabov, Andrey, Cygelnikov, Stansilav, Pikin, Oleg, Aleksandrov, Oleg, Bagrov, Vladimir, Gusev, Aleksandr, Toneev, Evgeniy, Surkova, Viktoriya, Dotdaev, Aznaur. Primary Leiomyosarcoma of the Superior Vena Cava: A Rare Case Report. سامانه مدیریت نشریات علمی, 1405; 51(7): 523-527. doi: 10.30476/ijms.2026.109892.4532

Primary Leiomyosarcoma of the Superior Vena Cava: A Rare Case Report

Iranian Journal of Medical Sciences
مقاله 6، دوره 51، شماره 7، مهر 2026، صفحه 523-527    اصل مقاله (1.98 M)
نوع مقاله: Case Report(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2026.109892.4532
نویسندگان
Andrey Ryabov1؛ Stansilav Cygelnikov1؛ Oleg Pikin1؛ Oleg Aleksandrov* 2؛ Vladimir Bagrov1؛ Aleksandr Gusev1؛ Evgeniy Toneev3؛ Viktoriya Surkova1؛ Aznaur Dotdaev1
1P. Hertsen Moscow Oncology Research Institute (MORI), Branch of the Federal State Budgetary Institution “National Medical Research Radiological Centre” (NMRRC), Ministry of Health of the Russian Federation, Moscow, Russian Federation
2University College London Hospitals NHS Foundation Trust (UCLH), London, United Kingdom
3Department of Hospital Surgery, Anesthesiology, Reanimatology, Urology, Traumatology, and Orthopedics, T.Z. Biktimirov Faculty of Medicine, Institute of Medicine, Ecology and Physical Culture, Ulyanovsk State University, 42 Lev Tolstoy St., Ulyanovsk, 432071, Russian Federation
چکیده
Leiomyosarcoma of the superior vena cava (SVC) is an exceptionally rare vascular tumor. Fewer than 20 cases were reported worldwide. Because of the nonspecific nature of the presenting symptoms and their deep mediastinal location, a pre‑operative diagnosis is often difficult or impossible. A 63‑year‑old woman presented with progressive facial and upper‑limb edema. Computed tomography (CT) demonstrated a hyper vascular intraluminal mass originating in the SVC and extending towards the right atrium. Percutaneous biopsy was considered unsafe due to the risk of hemorrhage. Therefore, radical surgical resection of the SVC and brachiocephalic veins with xenopericardial patch reconstruction was performed. Histological and immunohistochemical examination confirmed a grade two leiomyosarcoma. No adjuvant therapy was given. At 8‑month follow‑up, there was no evidence of recurrence. Primary SVC leiomyosarcoma is a rare and diagnostically challenging condition. Pre‑operative biopsy is often not feasible, and radical en bloc resection with vascular reconstruction remains the cornerstone of treatment, offering the best chance of recurrence‑free survival. Histopathological confirmation is required to establish the diagnosis, and the role of adjuvant therapy remains uncertain. 

تازه های تحقیق

Andrey Ryabov (Google Scholar)
Oleg Aleksandrov (Google Scholar)

کلیدواژه‌ها
Vena cava, Superior؛ Leiomyosarcoma؛ Anastomosis, Surgical؛ Vascular neoplasms
مراجع
  1. Kyriazi MA, Stafyla VK, Chatzinikolaou I, Koureas A, Chatziioannou A, Kondi-Paphiti A, et al. Surgical challenges in the treatment of leiomyosarcoma of the inferior vena cava: analysis of two cases and brief review of the literature. Ann Vasc Surg. 2010;24:826. doi: 10.1016/j.avsg.2010.02.039. PubMed PMID: 20471215.
  2. Wachtel H, Gupta M, Bartlett EK, Jackson BM, Kelz RR, Karakousis GC, et al. Outcomes after resection of leiomyosarcomas of the inferior vena cava: a pooled data analysis of 377 cases. Surg Oncol. 2015;24:21-7. doi: 10.1016/j.suronc.2014.10.007. PubMed PMID: 25433957.
  3. Ishikawa M, Ishikawa H, Fukui T, Ikeda M, Ono K. An extremely rare case of anterior mediastinal leiomyosarcoma: a case report. J Surg Case Rep. 2022;2022:513. doi: 10.1093/jscr/rjac513. PubMed PMID: 36381987; PubMed Central PMCID: PMCPMC9662833.
  4. de Chaumont A, Pierret C, de Kerangal X, Le Moulec S, Laborde F. Leiomyosarcoma of the superior vena cava. Ann Thorac Surg. 2014;98:725-7. doi: 10.1016/j.athoracsur.2013.09.106. PubMed PMID: 25087805.
  5. Balaz P, Whitley A, Heinola I, Gargiulo M, Vikatmaa P, Group OVSCA. Surgical Management of Tumours Invading the Inferior Vena Cava: A Delphi Consensus Document. Eur J Vasc Endovasc Surg. 2025;70:389-99. doi: 10.1016/j.ejvs.2025.03.034. PubMed PMID: 40185394.
  6. Chawla S, Zhang Q, Gwozdz AM, Wijaya J, Tiwana B, Tincknell L, et al. Editor’s Choice - A Systematic Review and Meta-analysis of 24 Month Patency After Endovenous Stenting of Superior Vena Cava, Subclavian, and Brachiocephalic Vein Stenosis. Eur J Vasc Endovasc Surg. 2025;69:139-55. doi: 10.1016/j.ejvs.2024.07.006. PubMed PMID: 38977059.
  7. Kerrison WGJ, Thway K, Jones RL, Huang PH. The biology and treatment of leiomyosarcomas. Crit Rev Oncol Hematol. 2023;184:103955. doi: 10.1016/j.critrevonc.2023.103955. PubMed PMID: 36893945.
  8. Emelyanova AG, Zolotovskaia MA, Poddubskaya EV, Modestov AA, Prassolov VS, Kuzmin DV, et al. Activation of the ERK1/2 Molecular Pathways and Its Relation to the Pathogenicity of Human Malignant Tumors. Acta Naturae. 2025;17:36-51. doi: 10.32607/actanaturae.27497. PubMed PMID: 40264578; PubMed Central PMCID: PMCPMC12011182.
  9. Chudasama P, Mughal SS, Sanders MA, Hubschmann D, Chung I, Deeg KI, et al. Integrative genomic and transcriptomic analysis of leiomyosarcoma. Nat Commun. 2018;9:144. doi: 10.1038/s41467-017-02602-0. PubMed PMID: 29321523; PubMed Central PMCID: PMCPMC5762758.
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