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Abbasi, Hosein, Vazin, Afsaneh, Moezzi, Seyed Mohammad Iman, Ahvar, Negar, Shorafa, Eslam, Hojabri, Katayoon, Abootalebi, Seyedeh Narjes, Javanmardi, Fatemeh, Shafiekhani, Mojtaba. (1404). Drug-Drug Interactions Among Pediatric Intensive Care Unit: Risk Factors and Clinical Outcomes. سامانه مدیریت نشریات علمی, 12(1), 93-102. doi: 10.30476/tips.2026.110716.1351
Hosein Abbasi; Afsaneh Vazin; Seyed Mohammad Iman Moezzi; Negar Ahvar; Eslam Shorafa; Katayoon Hojabri; Seyedeh Narjes Abootalebi; Fatemeh Javanmardi; Mojtaba Shafiekhani. "Drug-Drug Interactions Among Pediatric Intensive Care Unit: Risk Factors and Clinical Outcomes". سامانه مدیریت نشریات علمی, 12, 1, 1404, 93-102. doi: 10.30476/tips.2026.110716.1351
Abbasi, Hosein, Vazin, Afsaneh, Moezzi, Seyed Mohammad Iman, Ahvar, Negar, Shorafa, Eslam, Hojabri, Katayoon, Abootalebi, Seyedeh Narjes, Javanmardi, Fatemeh, Shafiekhani, Mojtaba. (1404). 'Drug-Drug Interactions Among Pediatric Intensive Care Unit: Risk Factors and Clinical Outcomes', سامانه مدیریت نشریات علمی, 12(1), pp. 93-102. doi: 10.30476/tips.2026.110716.1351
Abbasi, Hosein, Vazin, Afsaneh, Moezzi, Seyed Mohammad Iman, Ahvar, Negar, Shorafa, Eslam, Hojabri, Katayoon, Abootalebi, Seyedeh Narjes, Javanmardi, Fatemeh, Shafiekhani, Mojtaba. Drug-Drug Interactions Among Pediatric Intensive Care Unit: Risk Factors and Clinical Outcomes. سامانه مدیریت نشریات علمی, 1404; 12(1): 93-102. doi: 10.30476/tips.2026.110716.1351

Drug-Drug Interactions Among Pediatric Intensive Care Unit: Risk Factors and Clinical Outcomes

Trends in Pharmaceutical Sciences and Technologies
دوره 12، شماره 1، خرداد 2026، صفحه 93-102    اصل مقاله (442.58 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2026.110716.1351
نویسندگان
Hosein Abbasi1؛ Afsaneh Vazin1؛ Seyed Mohammad Iman Moezzi2؛ Negar Ahvar1؛ Eslam Shorafa3؛ Katayoon Hojabri3؛ Seyedeh Narjes Abootalebi3؛ Fatemeh Javanmardi4؛ Mojtaba Shafiekhani* 1
1Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
2Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
3Department of Pediatrics, Division of Intensive Care Unit, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
4Department of Biostatistics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
Drug–drug interactions (DDIs) are a common concern in pediatric intensive care units (PICUs) and may increase the risk of medication-related adverse events. This study aimed to determine the frequency, categories, and associated factors of potential DDIs in a PICU. We conducted a cross-sectional study between June 2022 and February 2023 among children admitted for at least 48 hours to medical or surgical PICUs who received two or more prescribed medications. Potential DDIs were identified and classified using Lexi-Interact®️. Demographic and clinical data, as well as medication-related information, were collected prospectively, and severity and reliability ratings were recorded. Associations with potential DDIs were analyzed using univariable and multivariable logistic regression. Among 345 included patients, 1,858 potential DDIs were detected, including 1,248 (67%) category C interactions, 529 (29%) category D interactions, and 81 (4%) category X interactions. Potential DDIs were more frequent in the medical PICU than in the surgical PICU. The most frequent contraindicated (category X) interaction involved linezolid–methadone. In multivariable analysis, the number of prescribed drugs, use of sedative agents, and PICU type were significantly associated with the occurrence of potential DDIs. In conclusion, potential DDIs were common in this PICU cohort. Polypharmacy, particularly involving sedative agents, was an important modifiable factor associated with potential DDIs. Enhanced monitoring and medication review may help identify and manage high-risk potential DDIs in critically ill pediatric patients.

تازه های تحقیق

Afsaneh Vazin (Google Scholar)
Mojtaba Shafiekhani (Google Scholar)

کلیدواژه‌ها
Pediatrics؛ Critical care؛ Intensive care unit؛ Drug Interactions؛ Medication Errors
مراجع
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