LinkedIn

 آمار

تعداد نشریات21
تعداد شماره‌ها1,281
تعداد مقالات11,708
تعداد مشاهده مقاله82,571,562
تعداد دریافت فایل اصل مقاله121,487,774
Kunnath, Anil, Ahmad Hilmi, Sorfina, Kumar, Dinesh. (1405). Beyond Autoantibodies: The Predictive and Pathogenic Role of Pro-Inflammatory Cytokines in Type 1 Diabetes. سامانه مدیریت نشریات علمی, 23(2), 1-1. doi: 10.22034/iji.2026.108390.3096
Anil Philip Kunnath; Sorfina Ahmad Hilmi; Dinesh Kumar. "Beyond Autoantibodies: The Predictive and Pathogenic Role of Pro-Inflammatory Cytokines in Type 1 Diabetes". سامانه مدیریت نشریات علمی, 23, 2, 1405, 1-1. doi: 10.22034/iji.2026.108390.3096
Kunnath, Anil, Ahmad Hilmi, Sorfina, Kumar, Dinesh. (1405). 'Beyond Autoantibodies: The Predictive and Pathogenic Role of Pro-Inflammatory Cytokines in Type 1 Diabetes', سامانه مدیریت نشریات علمی, 23(2), pp. 1-1. doi: 10.22034/iji.2026.108390.3096
Kunnath, Anil, Ahmad Hilmi, Sorfina, Kumar, Dinesh. Beyond Autoantibodies: The Predictive and Pathogenic Role of Pro-Inflammatory Cytokines in Type 1 Diabetes. سامانه مدیریت نشریات علمی, 1405; 23(2): 1-1. doi: 10.22034/iji.2026.108390.3096

Beyond Autoantibodies: The Predictive and Pathogenic Role of Pro-Inflammatory Cytokines in Type 1 Diabetes

Iranian Journal of Immunology
دوره 23، شماره 2، شهریور 2026، صفحه 1-1
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22034/iji.2026.108390.3096
نویسندگان
Anil Philip Kunnath* 1؛ Sorfina Ahmad Hilmi2؛ Dinesh Kumar1
1IMU University
2IMU University Malaysia
چکیده
Type 1 diabetes (T1DM) is an autoimmune disorder marked by a characteristic dysfunction of insulin-secreting beta-cells in the pancreatic islets. This destructive process is not a single event but a chronic inflammatory cascade, propelled by immune cells—including T-lymphocytes and macrophages—that release potent pro-inflammatory cytokines.
This review delves into the growing body of evidence implicating specific inflammation-promoting mediators—including Interleukin-1β (IL-1β), Tumor Necrosis Factor-α (TNF-α) and Interferon-γ (IFN-γ) —as master regulators of beta-cell death. We also explore how modern analytical techniques enable precise mapping of cytokine patterns in the blood, revealing a dynamic and ongoing disease process long that precedes clinical symptoms onset.
By weaving together findings from clinical and preclinical studies, this article argues that profiling these inflammatory signals provides a crucial real-time, functional readout of autoimmune activity that complements traditional, static autoantibody measurements. We conclude by discussing the significant potential of integrating cytokine data into existing models to create more robust risk stratification tools and to pave the way for interventions that could intercept the disease pathway before critical beta-cell mass is lost.
کلیدواژه‌ها
Pro-inflammatory cytokines؛ β cells؛ Type 1 diabetes؛ Reactive oxygen species
آمار
تعداد مشاهده مقاله: 31


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب