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The Effect of Asacol (Mesalazine) Suppository on the Healing of Acute Fissures Caused by Diarrhea: A Randomized Controlled Trial | ||
| Iranian Journal of Colorectal Research | ||
| مقاله 3، دوره 13، شماره 4، اسفند 2025، صفحه 128-133 اصل مقاله (1.02 M) | ||
| نوع مقاله: Research/Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/acrr.2026.110177.1279 | ||
| نویسندگان | ||
| Leila Ghahramani1؛ Seyed Vahid Hosseini1؛ Hajar Khazraei* 2؛ Sajad Heshmati Far3؛ Khadijeh Gorgi1 | ||
| 1Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 2Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 3Colorectal research center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| Background: An anal fissure is a linear, superficial tear in the squamous epithelium of the anus, specifically in the anoderm distal to the dentate line. Given the well-established anti-inflammatory properties of mesalazine in acute conditions, it helps prevent secondary stricture and reduces the risk of complications such as incontinence that may arise during fissure surgery. This study investigates the effect of Asacol (Mesalazine) suppositories in the treatment of acute anal fissures caused by diarrhea, compared to a placebo. Methods: This double-blind, randomized controlled clinical trial involved 69 patients aged 18 to 65 years who experienced diarrhea followed by acute fissure symptoms lasting less than six weeks. Participants were randomly assigned and blinded into two groups: 34 in the control group and 35 in the treatment group. Both groups applied diltiazem ointment three times daily and took hot water basin baths twice daily. The control group received a placebo, while the treatment group was administered Asacol suppositories. The primary outcome measures were the degree of pain reduction and the speed of recovery. Results: The findings indicated that the recovery rate in the experimental group (80%) was significantly higher than in the control group (38.2%) (P<0.001). The current study also investigated the consumption of coffee and the incidence of anal fissures, revealing that the likelihood of recovery was not associated with tea or coffee consumption. Additionally, patient age showed no significant relationship with the chance of recovery; the mean age of the study population was 43.49±15.08 years. Conclusion: The findings of the current study indicate that Asacol suppositories have a significant effect on the healing of acute anal fissures caused by diarrhea and can be considered a viable treatment option. | ||
تازه های تحقیق | ||
Leila_Ghahramani (Google Scholar) Hajar Khazraei (Google Scholar) | ||
| کلیدواژهها | ||
| Asacol Suppository؛ Diarrhea؛ Acute anal Fissures | ||
| مراجع | ||
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1. Gallo G, Pegoraro V, Trompetto M. Description and management of patients with anal fissure: insights on Italian primary care setting coming from real-world data. Updates in Surgery. 2024;76(6):2193-203. 2. Beaty JS, Shashidharan M. Anal Fissure. Clinics in colon and rectal surgery. 2016;29(1):30-7. 3. Schouten WR, Briel JW, Auwerda JJ. Relationship between anal pressure and anodermal blood flow. The vascular pathogenesis of anal fissures. Diseases of the colon and rectum. 1994;37(7):664-9. 4. Emile SH, Elgendy H, Elfeki H, et al. Does the duration of symptoms of anal fissure impact its response to conservative treatment? A prospective cohort study. International journal of surgery (London, England). 2017;44:64-70. 5. van Hogezand RA, van Hees PA, van Gorp JP, et al. Double-blind comparison of 5-aminosalicylic acid and acetyl-5-aminosalicylic acid suppositories in patients with idiopathic proctitis. Alimentary pharmacology & therapeutics. 1988;2(1):33-40. 6. Pawar A, Rao PP, Kumar A, et al. A randomized controlled trial to compare local steroid injection versus lateral internal sphincterotomy for chronic fissure in ano: A pilot study. Medical Journal Armed Forces India. 2025. 7. Medhi B, Prakash A, Upadhyay S, et al. Comparison of observational and controlled clinical trials of diltiazem in the treatment of chronic anal fissure. J Indian Journal of Surgery. 2011;73(6):427-31. 8. Gupta PJ. Effects of warm water sitz bath on symptoms in post-anal sphincterotomy in chronic anal fissure--a randomized and controlled study. World journal of surgery. 2007;31(7):1480-4. 9. Salari M, Salari R, Dadgarmoghadam M, et al. Efficacy of egg yolk and nitroglycerin ointment as treatments for acute anal fissures: A randomized clinical trial study. Electronic physician. 2016;8(10):3035-41. 10. Shen Q, Riedl KM, Cole RM, et al. Egg yolks inhibit activation of NF-κB and expression of its target genes in adipocytes after partial delipidation. Journal of agricultural and food chemistry. 2015;63(7):2013-25. 11. Mapel DW, Schum M, Von Worley A. The epidemiology and treatment of anal fissures in a populationbased cohort. BMC gastroenterology. 2014;14:129. | ||
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