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Anti-Inflammatory Effect of Acetylcysteine and Royal Jelly against Fluoxetine-Induced Hepatotoxicity in Rats | ||
| International Journal of Nutrition Sciences | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 30 خرداد 1405 اصل مقاله (908.16 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/ijns.2026.106743.1463 | ||
| نویسندگان | ||
| Azad Hayal Nahy1؛ Manal Abdulkhaliq Ibrahim* 2؛ Manal N ALhayder2 | ||
| 1Ministry of Health, Thi Qar Health Directorate, Al Hussain Teaching Hospital, Thi Qar, Iraq | ||
| 2Department of Pharmacology and Toxicology, College of Pharmacy, University of Basrah, Basrah, Iraq | ||
| چکیده | ||
| Background: Hepatic toxicity of antipsychotic drugs needs to be protected by hepatoprotective medications. This study evaluated the antiinflammatory effect of N-acetylcysteine (NAC) and Royal jelly against hepatotoxicity of fluoxetine in rats. Methods: Thirty adult female rats were divided into five equal groups of 6 rats. Group A was considered negative control. Group B were rats administered orally by fluoxetine (10 mg\kg) to induce hepatotoxicity. Group C were animals pre-treated with oral NAC (200 mg\kg) and then fluoxetine (10 mg\kg). Group D was pre-treated with Royal jelly (150 mg\kg) following the use of fluoxetine (10 mg\kg). Group E was pretreated with oral Royal jelly and NAC following fluoxetine utilization. After completion of 28 days of treatment, the rats were euthanized and a blood sample was collected and evaluated for inflammatory cytokines of tumor necrotizing factor alpha (TNF-α), interleukin-10 (IL10) and oxidative stress biomarkers of malondialdehyde (MDA) and glutathione (GSH) by ELISA. Results: Fluoxetine induced hepatotoxicity and an increase in inflammatory cytokines such as TNF-α. Royal jelly and NAC showed significant anti-inflammatory and antioxidant effects by reduction in inflammatory cytokines and oxidative parameters. Conclusion: Both NAC and Royall jelly were shown to have antioxidant and anti-inflammatory activities, even NAC impact was more than Royal jelly against hepato toxicity induced by fluoxetine. | ||
| کلیدواژهها | ||
| Acetylcysteine؛ Fluoxetine؛ Hepatotoxicity؛ Inflammation؛ Royal jelly | ||
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آمار تعداد مشاهده مقاله: 11 تعداد دریافت فایل اصل مقاله: 5 |
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