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Mirzaei, Mohammad, Rahmanipour, Elham, Saffar Soflaei, Sara, Etemad, Leila, Samadi, Sara, A. Ferns, Gordon, Karimian, Maryam, Ghayour-Mobarhan, Majid. (1405). Association of Dietary Magnesium Intake and Non-Alcoholic Fatty Liver Disease: A Narrative Review. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijns.2026.107735.1519
Mohammad Mirzaei; Elham Rahmanipour; Sara Saffar Soflaei; Leila Etemad; Sara Samadi; Gordon A. Ferns; Maryam Saberi Karimian; Majid Ghayour-Mobarhan. "Association of Dietary Magnesium Intake and Non-Alcoholic Fatty Liver Disease: A Narrative Review". سامانه مدیریت نشریات علمی, , , 1405, -. doi: 10.30476/ijns.2026.107735.1519
Mirzaei, Mohammad, Rahmanipour, Elham, Saffar Soflaei, Sara, Etemad, Leila, Samadi, Sara, A. Ferns, Gordon, Karimian, Maryam, Ghayour-Mobarhan, Majid. (1405). 'Association of Dietary Magnesium Intake and Non-Alcoholic Fatty Liver Disease: A Narrative Review', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijns.2026.107735.1519
Mirzaei, Mohammad, Rahmanipour, Elham, Saffar Soflaei, Sara, Etemad, Leila, Samadi, Sara, A. Ferns, Gordon, Karimian, Maryam, Ghayour-Mobarhan, Majid. Association of Dietary Magnesium Intake and Non-Alcoholic Fatty Liver Disease: A Narrative Review. سامانه مدیریت نشریات علمی, 1405; (): -. doi: 10.30476/ijns.2026.107735.1519

Association of Dietary Magnesium Intake and Non-Alcoholic Fatty Liver Disease: A Narrative Review

International Journal of Nutrition Sciences
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 30 خرداد 1405    اصل مقاله (838.1 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijns.2026.107735.1519
نویسندگان
Mohammad Mirzaei1؛ Elham Rahmanipour2؛ Sara Saffar Soflaei3، 4؛ Leila Etemad4، 5؛ Sara Samadi6؛ Gordon A. Ferns7؛ Maryam Saberi Karimian* 3؛ Majid Ghayour-Mobarhan3، 4
1Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
5Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
6Depatment of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
7Brighton and Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK
چکیده
Background: Non-alcoholic fatty liver disease (NAFLD), now known as metabolic dysfunction-associated steatotic liver disease (MASLD), is the most common chronic liver disorder globally. It is closely linked to obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome. Dietary factors and micronutrient status may influence its development and progression. Magnesium (Mg), an essential mineral involved in glucose and lipid metabolism, has been suggested as a potential modulator of NAFLD, although the evidence remains inconclusive. This narrative review aimed to summarize experimental, observational, and interventional studies published since 2000 that have explored the relationship between Mg intake and NAFLD.
Results: Preclinical studies indicated that Mg deficiency contributes to mitochondrial dysfunction, oxidative stress, and hepatic lipid accumulation, while supplementation may reduce inflammation and fibrosis. Observational studies showed a negative association between Mg intake and NAFLD risk, although, findings vary among different populations. Randomized controlled trials were limited and demonstrated mixed results, with some revealing improvement in liver enzymes and lipid profile, while others illustrated no significant benefits.
Conclusion: While there is biological plausibility and initial data supporting a potential protective role of Mg in NAFLD, the current evidence did not establish a causal relationship. Larger, well-designed clinical trials are needed to determine whether Mg supplementation could be an effective preventive or therapeutic approach in NAFLD. 
کلیدواژه‌ها
Non-alcoholic Fatty Liver؛ Disease؛ NAFLD؛ Metabolic dysfunctionassociated steatotic liver disease؛ MASLD؛ Magnesium
مراجع
  1. Powell EE, Wong VWS, Rinella M. Non-alcoholic fatty liver disease. Lancet. 2021;397:2212–24. DOI: 10.1016/S0140-6736(20)32511-3. PMID: 33894145.
  2. Rinella ME, Lazarus JV, Ratziu V, et al. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. Hepatology. 2023;78:1966-86. DOI: 10.1097/HEP.0000000000000696. PMID: 37983810.
  3. Ranjbar T, Masoumi SJ. The Effect of Stevia Rebaudiana on Nonalcoholic Fatty Liver Disease (NAFLD): A Review. Int J Nutr Sci. 2018;3:2-6.
  4. Younossi ZM, Koenig AB, Abdelatif D, et al. Global epidemiology of nonalcoholic fatty liver disease—meta‐analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64:73-84. DOI: 10.1002/hep.28431. PMID: 26707365.
  5. Fouzi M, Razmi N, Mehrabani D. The Effect of Citrullus Colocynthis on Serum Lipid Profile and Hepatic Histology in CCl 4-Induced Liver Injury Rat Model. Int J Nutr Sci. 2020;5:208-213. DOI: 10.30476/IJNS.2020.88244.1094.
  6. Riazi K, Azhari H, Charette JH, et al. The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2022;7:851-61. DOI: 10.1016/S2468-1253(22)00165-0. PMID: 35798021.
  7. Neuschwander-Tetri BA. Non-alcoholic fatty liver disease. BMC Med. 2017;15:45. PMID: 28241825. DOI: 10.1186/s12916-017-0806-8
  8. Fujii H, Kawada N, Japan Study Group of Nafld (JSG-NAFLD). The role of insulin resistance and diabetes in nonalcoholic fatty liver disease. Int J Mol Sci. 2020;21:3863. DOI: 10.3390/ijms21113863. PMID: 32485838.
  9. Cobbina E, Akhlaghi F. Non-alcoholic fatty liver disease (NAFLD)–pathogenesis, classification, and effect on drug metabolizing enzymes and transporters. Drug Metab Rev. 2017;49:197-211. DOI: 10.1080/03602532.2017.1293683. PMID: 28303724.
  10. Ko E, Yoon EL, Jun DW. Risk factors in nonalcoholic fatty liver disease. Clin Mol Hepatol. 2022;29:S79-S85. DOI: 10.3350/cmh.2022.0398. PMID: 36517003.
  11. Lee KJ, Moon JS, Kim NY, et al. Effects of PNPLA3, TM6SF2 and SAMM50 on the development and severity of non‐alcoholic fatty liver disease in children. Pediatr Obes. 2022;17:e12852. DOI: 10.1111/ijpo.12852. PMID: 34490745.
  12. Kolaric TO, Nincevic V, Kuna L, et al. Drug-induced fatty liver disease: Pathogenesis and treatment. J Clin Transl Hepatol. 2021;9:731-737. DOI: 10.14218/JCTH.2020.00091. PMID: 34722188.
  13. Adams LA, Anstee QM, Tilg H, et al. Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases. Gut. 2017;66:1138–53. DOI: 10.1136/gutjnl-2017-313884. PMID: 28314735.
  14. European Association for the Study of the Liver (EASL) EA for the S of D (EASD) European Association for the Study of Obesity (EASO). EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. Obes Facts. 2016;9:65-90. DOI: 10.1159/000443344. PMID: 27055256.
  15. Pickett-Blakely O, Young K, Carr RM. Micronutrients in nonalcoholic fatty liver disease pathogenesis. Cell Mol Gastroenterol Hepatol. 2018;6:451-62. DOI: 10.1016/j.jcmgh.2018.07.004. PMID: 30294653.
  16. Mehrabani D, Arshi S, Sadeghi L, et al. The Ameliorating Effect of Adipose Tissue Stem Cells on Liver Function in Experimental Rats with Liver Fibrosis. Int J Nutr Sci. 2022;7:225-232. DOI: 10.30476/ijns.2022.97438.1211.
  17. Fiorentini D, Cappadone C, Farruggia G, et al. Magnesium: biochemistry, nutrition, detection, and social impact of diseases linked to its deficiency. Nutrients. 2021;13:1136. DOI: 10.3390/nu13041136. PMID: 33808247.
  18. Rahmanian E, Tanideh N, Karbalay-Doust S, et al. The effect of topical magnesium on healing of pre-clinical burn wounds. Burns. 2024;50:630-640. DOI: 10.1016/j.burns.2023.10.015. PMID: 37980271.
  19. Eshraghian A, Nikeghbalian S, Geramizadeh B, et al. Serum magnesium concentration is independently associated with non-alcoholic fatty liver and non-alcoholic steatohepatitis. United European Gastroenterol J. 2018;6:97-103. DOI: 10.1177/2050640617707863. PMID: 29435319.
  20. Simón J, Goikoetxea-Usandizaga N, Serrano-Maciá M, et al. Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH. J Hepatol. 2021;75:34-45. DOI: 10.1016/j.jhep.2021.01.043. PMID: 33571553.
  21. Wu L, Zhu X, Fan L, et al. Magnesium intake and mortality due to liver diseases: Results from the Third National Health and Nutrition Examination Survey Cohort. Sci Rep. 2017;7:17913. DOI: 10.1038/s41598-017-18076-5. PMID: 29263344.
  22. Lu L, Chen C, Li Y, et al. Magnesium intake is inversely associated with risk of non-alcoholic fatty liver disease among American adults. Eur J Nutr. 2022;61:1245-54. DOI: 10.1007/s00394-021-02732-8. PMID: 34741649.
  23. Zolfaghari H, Askari G, Siassi F, et al. Intake of nutrients, fiber, and sugar in patients with nonalcoholic fatty liver disease in comparison to healthy individuals. Int J Prev Med. 2016;7:98. DOI: 10.4103/2008-7802.188083. PMID: 27625763.
  24. Salehi-Sahlabadi A, Teymoori F, Ahmadirad H, et al. Nutrient patterns and non-alcoholic fatty liver disease in Iranian Adul: A case-control study. Front Nutr. 2022;9:977403. DOI: 10.3389/fnut.2022.977403. PMID: 36147306.
  25. Chen S, Luo S, Zou B, et al. Magnesium supplementation stimulates autophagy to reduce lipid accumulation in hepatocytes via the AMPK/mTOR pathway. Biol Trace Elem Res. 2023;201:3311-22. PMID: 36224316. DOI: 10.1007/s12011-022-03438-6.
  26. Pereira PD, Serra-Caetano A, Cabrita M, et al. Quantification of cell cycle kinetics by EdU (5-ethynyl-2′-deoxyuridine)-coupled-fluorescence-intensity analysis. Oncotarget. 2017;8:40514-40532. DOI: 10.18632/oncotarget.17121. PMID: 28465489.
  27. Lu L, Hao K, Hong Y, et al. Magnesium isoglycyrrhizinate reduces hepatic lipotoxicity through regulating metabolic abnormalities. Int J Mol Sci. 2021;22:5884. DOI: 10.3390/ijms22115884. PMID: 34070938.
  28. Xu Q, Wang J, Chen F, et al. Protective role of magnesium isoglycyrrhizinate in non-alcoholic fatty liver disease and the associated molecular mechanisms. Int J Mol Med. 2016;38:275-82. DOI: 10.3892/ijmm.2016.2603. PMID: 27220460.
  29. Shahsavani Z, Asadi AH, Shamshirgardi E, et al. Vitamin D, Magnesium and Their Interactions: A Review. Int J Nutr Sci. 2021;6:113-118. DOI: 10.30476/IJNS.2021.91766.1144.
  30. Abou Nehmi V, Murata GM, de Moraes RCM, et al. A novel supplement with yeast β-glucan, prebiotic, minerals and Silybum marianum synergistically modulates metabolic and inflammatory pathways and improves steatosis in obese mice. J Integr Med. 2021;19:439-50. DOI: 10.1016/j.joim.2021.05.002. PMID: 34108131.
  31. Fengler VH, Macheiner T, Goessler W, et al. Hepatic Response of Magnesium-Restricted Wild Type Mice. Metabolites. 2021;11:762. DOI: 10.3390/metabo11110762. PMID: 34822420.
  32. Hsieh SK, Lin NH, Chen YJ, et al. Therapeutic Effects of Lithospermate B Complexed with Mg2+ or Zn2+ on Metabolic Syndrome Induced in Rats Fed with High-Fat Diet. Molecules. 2020;25:983. DOI: 10.3390/molecules25040983. PMID: 32098371.
  33. Zhang Q, Qian ZY, Zhou PH, et al. Effects of oral selenium and magnesium co-supplementation on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in rats fed a high-fat diet. Lipids Health Dis. 2018;17:165. DOI: 10.1186/s12944-018-0815-4. PMID: 30031400.
  34. Tanaka H, Fukahori S, Baba S, et al. Branched‐Chain Amino Acid–Rich Supplements Containing Microelements Have Antioxidant Effects on Nonalcoholic Steatohepatitis in Mice. JPEN J Parenter Enter Nutr. 2016;40:519-28. DOI: 10.1177/0148607114555160. PMID: 25316683.
  35. Aktary ML, Eller LK, Nicolucci AC, et al. Cross-sectional analysis of the health profile and dietary intake of a sample of Canadian adults diagnosed with non-alcoholic fatty liver disease. Food Nutr Res. 2020;64:10-29219. DOI: 10.29219/fnr.v64.4548. PMID: 33061886.
  36. Vranešić Bender D, Nutrizio M, Jošić M, et al. Nutritional status and nutrition quality in patients with non-alcoholic fatty liver disease. Acta Clin Croat. 2017;56:625-34. DOI: 10.20471/acc.2017.56.04.07.
  37. Mazidi M, Ofori‐Asenso R, Kengne AP. Dietary patterns are associated with likelihood of hepatic steatosis among US adults. J Gastroenterol Hepatol. 2020;35:1916-22. DOI: 10.1111/jgh.15076. PMID: 32335964.
  38. Li W, Zhu X, Song Y, et al. Intakes of magnesium, calcium and risk of fatty liver disease and prediabetes. Public Health Nutr. 2018;21:2088-95. DOI: 10.1017/S1368980018000642. PMID: 29607802.
  39. Tayyem RF, Al-Dayyat HM, Rayyan YM. Relationship between lifestyle factors and nutritional status and non-alcoholic fatty liver disease among a group of adult Jordanians. Arab J Gastroenterol. 2019;20:44-9. DOI: 10.1016/j.ajg.2019.01.008. PMID: 30872135.
  40. Emamat H, Ghalandari H, Totmaj AS, et al. Calcium to magnesium intake ratio and non-alcoholic fatty liver disease development: a case-control study. BMC Endocr Disord. 2021;21:51. DOI: 10.1186/s12902-021-00721-w. PMID: 33736626.
  41. Tao MH, Fulda KG. Association of magnesium intake with liver fibrosis among adults in the United States. Nutrients. 2021;13:142. DOI: 10.3390/nu13010142. PMID: 33401667.
  42. Vahid F, Hekmatdoost A, Mirmajidi S, et al. Association between index of nutritional quality and nonalcoholic fatty liver disease: the role of vitamin D and B group. Am J Med Sci. 2019;358:212-8. DOI: 10.1016/j.amjms.2019.06.008. PMID: 31326093.
  43. Crommen S, Rheinwalt KP, Plamper A, et al. A Specifically Tailored Multistrain Probiotic and Micronutrient Mixture Affects Nonalcoholic Fatty Liver Disease—Related Markers in Patients with Obesity after Mini Gastric Bypass Surgery. J Nutr. 2022;152:408-18. DOI: 10.1093/jn/nxab392. PMID: 34919684.
  44. Gravina AG, Romeo M, Pellegrino R, et al. Just drink a glass of water? Effects of bicarbonate–sulfate–calcium–magnesium water on the gut–liver axis. Front Pharmacol. 2022;13:869446. DOI: 10.3389/fphar.2022.869446. PMID: 35837275.
  45. Haiyan G, Haoran Y, Huilian S, et al. Magnesium isoglycyrrhizinate versus compound glycyrrhizin in treatment of patients with non-alcoholic fatty liver disease. J Clin Med Pract. 2021;25:36-9. DOI: 10.7619/jcmp.20211632.
  46. Tian Y, Tang X, Li H, et al. Clinical effect of magnesium isoglycyrrhizinate on moderate and severe nonalcoholic steatohepatitis and its mechanism analyse. Chin J Biochem Pharm. 2014;112-4.
  47. Hazzan R, Ahmad N, Slim W, et al. Hepatoprotective effect of combination of L-carnitine and magnesium-hydroxide in nonalcoholic fatty liver disease patients: a double-blinded randomized controlled pilot study. Eur Rev Med Pharmacol Sci. 2022;26:7522-7532. DOI: 10.26355/eurrev_202210_30023. PMID: 36314323.
  48. Karandish M, Tamimi M, Shayesteh AA, et al. The effect of magnesium supplementation and weight loss on liver enzymes in patients with nonalcoholic fatty liver disease. J Res Med Sci. 2013;18:573-9. PMID: 24516489.
  49. Mehrabani D, Masoumi SJ, Masoumi AS, et al. Role of diet in mesenchymal stem cells’ function: a review. Int J Nutr Sci. 2023;8:9-19. DOI: 10.30476/ijns.2023.97788.1221.
  50. Jamhiri I, Zahri S, Mehrabani D, et al. Enhancing the apoptotic effect of il-24/mda-7 on the human hepatic stellate cell through rgd peptide modification. Immunol Invest. 2018;47:335-350. DOI: 10.1080/08820139.2018.1433202. PMID: 29498551.
  51. Jamhiri I, Zahri S, Mehrabani D, et al. The modulatory role of endogenous il-24/mda-7 in inflammatory response of human hepatic stellate cell (hsc), lx2. J Arak Univ Med Sci. 2018;20:13-21.
  52. Jamhiri I, Hosseini SY, Mehrabani D, et al. The pattern of il-24/mda-7 and its cognate receptors expression following activation of human hepatic stellate cells. Biomed Rep. 2017;7:173-178. DOI: 10.3892/br.2017.931. PMID: 28804632.
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