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Kannan, Adithyan, Priyadharsini Jayaseelan, Vijayashree. (1405). Altered PLAU Expression in Porphyromonas gingivalis-Treated Human Immortalised Oral Epithelial Cells and Its Putative Role in Head and Neck Squamous Cell Carcinoma. سامانه مدیریت نشریات علمی, 17(4), 297-311. doi: 10.30476/mejc.2026.106070.2255
Adithyan Kannan; Vijayashree Priyadharsini Jayaseelan. "Altered PLAU Expression in Porphyromonas gingivalis-Treated Human Immortalised Oral Epithelial Cells and Its Putative Role in Head and Neck Squamous Cell Carcinoma". سامانه مدیریت نشریات علمی, 17, 4, 1405, 297-311. doi: 10.30476/mejc.2026.106070.2255
Kannan, Adithyan, Priyadharsini Jayaseelan, Vijayashree. (1405). 'Altered PLAU Expression in Porphyromonas gingivalis-Treated Human Immortalised Oral Epithelial Cells and Its Putative Role in Head and Neck Squamous Cell Carcinoma', سامانه مدیریت نشریات علمی, 17(4), pp. 297-311. doi: 10.30476/mejc.2026.106070.2255
Kannan, Adithyan, Priyadharsini Jayaseelan, Vijayashree. Altered PLAU Expression in Porphyromonas gingivalis-Treated Human Immortalised Oral Epithelial Cells and Its Putative Role in Head and Neck Squamous Cell Carcinoma. سامانه مدیریت نشریات علمی, 1405; 17(4): 297-311. doi: 10.30476/mejc.2026.106070.2255

Altered PLAU Expression in Porphyromonas gingivalis-Treated Human Immortalised Oral Epithelial Cells and Its Putative Role in Head and Neck Squamous Cell Carcinoma

Middle East Journal of Cancer
مقاله 2، دوره 17، شماره 4 - شماره پیاپی 68، دی 2026، صفحه 297-311    اصل مقاله (3.79 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2026.106070.2255
نویسندگان
Adithyan Kannan1، 2؛ Vijayashree Priyadharsini Jayaseelan* 2
1Department of Microbiology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences [SIMATS], Saveetha University, Chennai, India
2Clinical Genetics Lab, Centre for Cellular and Molecular Research, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences [SIMATS], Saveetha Universi ty, Chennai, India
چکیده
Background: Porphyromonas gingivalis, a key pathogen in periodontitis, has been implicated in oral carcinogenesis. The present study investigated the dysregulated genes in human oral epithelial cells (HOEC) treated with P. gingivalis (Pg) and explored their potential involvement in the development of head and neck squamous cell carcinoma (HNSCC).
Method: A computational design, using GEOmnibus data was employed to extract key information on differentially expressed genes (DEGs) in HOEC treated with Pg. A curated list of the top 20 DEGs was then examined for their gene expression profiles and survival rates using the UALCAN database. To explore gene enrichment and protein interaction networks, the Metascape and STRING databases were used. Additionally, the effect of microRNA on the expression profiles of candidate genes shared by both phenotypes was examined using the miRDB portal.
Results: Among the 20 genes queried, the PLAU gene was found to be upregulated in both the Pg-treated cells and the HNSCC dataset. The high expression of this gene correlated with poor prognosis in HNSCC patients. Furthermore, the microRNA hsa-miR-23b-3p, identified as targeting PLAU, was significantly downregulated, resulting in poor prognosis in HNSCC patients.
Conclusion: Our study reveals that Pg infection induced significant alterations in the gene expression in HOEC. The PLAU gene was identified as an important gene that demonstrated a putative association with periodontal disease and HNSCC. The influence of epigenetic markers, such as non-coding RNAs, and the methylation profile of the gene requires further investigation.

تازه های تحقیق

Vijayashree Priyadharsini Jayaseelan (google scholar)

کلیدواژه‌ها
Bacterial infections؛ Disease؛ Genes؛ Periodontitis؛ Prognosis
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