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Poojar, Sridhar, Tejaswi siddappa, Poornachandra, Desai, Vinay, Thimmaiah, Naveen. (1405). Evaluation of Toxicity Profiles of Lacrimal Glands in Nasopharyngeal Carcinoma Patients Treated with Volumetric Modulated Arc Therapy. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/mejc.2026.106311.2263
Sridhar Poojar; Poornachandra Tejaswi siddappa; Vinay Desai; Naveen Thimmaiah. "Evaluation of Toxicity Profiles of Lacrimal Glands in Nasopharyngeal Carcinoma Patients Treated with Volumetric Modulated Arc Therapy". سامانه مدیریت نشریات علمی, , , 1405, -. doi: 10.30476/mejc.2026.106311.2263
Poojar, Sridhar, Tejaswi siddappa, Poornachandra, Desai, Vinay, Thimmaiah, Naveen. (1405). 'Evaluation of Toxicity Profiles of Lacrimal Glands in Nasopharyngeal Carcinoma Patients Treated with Volumetric Modulated Arc Therapy', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/mejc.2026.106311.2263
Poojar, Sridhar, Tejaswi siddappa, Poornachandra, Desai, Vinay, Thimmaiah, Naveen. Evaluation of Toxicity Profiles of Lacrimal Glands in Nasopharyngeal Carcinoma Patients Treated with Volumetric Modulated Arc Therapy. سامانه مدیریت نشریات علمی, 1405; (): -. doi: 10.30476/mejc.2026.106311.2263

Evaluation of Toxicity Profiles of Lacrimal Glands in Nasopharyngeal Carcinoma Patients Treated with Volumetric Modulated Arc Therapy

Middle East Journal of Cancer
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 10 تیر 1405    اصل مقاله (289.41 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2026.106311.2263
نویسندگان
Sridhar Poojar1؛ Poornachandra Tejaswi siddappa* 2؛ Vinay Desai3؛ Naveen Thimmaiah1
1Department of Radiation Oncology, Kidwai Memorial Institute of Oncology, Hombegowda Nagar, Bengaluru, Karnataka, India
2Department of Radiation Oncology, Karnataka Cancer Therapy and Research Institute, Hubli, Karnataka, India
3Department of Medical Physics, Kidwai memorial Institute of Oncology, Hombegowda Nagar, Bengaluru, Karnataka, India
چکیده
Background: Lacrimal gland forms the integral part of tear film production. In view of close proximity to treatment portals, the present study aimed to investigate the relationship between lacrimal gland radiotherapy dose and its toxicity among patients treated with volumetric modulated arc therapy for carcinoma nasopharynx.
Method: A total number of 50 nasopharynx cancer patients treated with 70Gray included in this mono-centric, prospective, observational study. The lacrimal glands contoured as part of organs at risk. Impact of planned target volume, distance of gland to this volume, dose received by glands and V30 are assessed. Slit-lamp examination and Schirmer-I test were used pre-treatment and post-treatment up to a period of 2-years. Radiation Therapy Oncology Group toxicity criteria were used to provide information on conjunctivitis, corneal ulceration, and sicca-keratitis. ‘R’ software v4.4 was used for statistical analysis and independent T-test to correlate the significance with P-value <0.05.
Results: The minimum, maximum, and mean dose (Gray) received by the right lacrimal gland, comparable with the dose delivered to left lacrimal gland, was 2.58, 17.44 and 10.01, respectively. The minimum, maximum and mean planned target volumes (cubic centimetre) were 188.12, 1612.33 and 893.45, respectively. The mean distance between lacrimal gland and planned target volume is 0.51 centimetre and found to be statistically significant with P-value <0.001. Ten Grade-I and three Grade-II toxicity were reported in the study.
Conclusion: Based on the findings of the present study, contouring lacrimal gland as organ at risk in carcinoma nasopharynx is recommended and dose constraints to be advised, to minimize the toxicity and to prevent dry eye syndrome.
کلیدواژه‌ها
Nasopharyngeal neoplasms؛ Conformal radiotherapy؛ Volumetric modulated arc therapy؛ Lacrimal gland؛ Dry eye syndrome
مراجع
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