LinkedIn

 آمار

تعداد نشریات21
تعداد شماره‌ها1,292
تعداد مقالات11,793
تعداد مشاهده مقاله83,088,125
تعداد دریافت فایل اصل مقاله121,853,824
Elsayed, Nehal, Hassan, Doaa, Ahmed, Nabila, Soliman, Mohamed, Elwan, Amira. (1405). Dose Sparing with Breath-Holding Compared with Free Breathing in Right Sided Breast Cancer Irradiation. سامانه مدیریت نشریات علمی, 17(3), 250-259. doi: 10.30476/mejc.2026.106378.2262
Nehal Gamal Elsayed; Doaa Abdelhady Hassan; Nabila Hassan Ahmed; Mohamed Ibrahim Soliman; Amira Elwan. "Dose Sparing with Breath-Holding Compared with Free Breathing in Right Sided Breast Cancer Irradiation". سامانه مدیریت نشریات علمی, 17, 3, 1405, 250-259. doi: 10.30476/mejc.2026.106378.2262
Elsayed, Nehal, Hassan, Doaa, Ahmed, Nabila, Soliman, Mohamed, Elwan, Amira. (1405). 'Dose Sparing with Breath-Holding Compared with Free Breathing in Right Sided Breast Cancer Irradiation', سامانه مدیریت نشریات علمی, 17(3), pp. 250-259. doi: 10.30476/mejc.2026.106378.2262
Elsayed, Nehal, Hassan, Doaa, Ahmed, Nabila, Soliman, Mohamed, Elwan, Amira. Dose Sparing with Breath-Holding Compared with Free Breathing in Right Sided Breast Cancer Irradiation. سامانه مدیریت نشریات علمی, 1405; 17(3): 250-259. doi: 10.30476/mejc.2026.106378.2262

Dose Sparing with Breath-Holding Compared with Free Breathing in Right Sided Breast Cancer Irradiation

Middle East Journal of Cancer
مقاله 7، دوره 17، شماره 3 - شماره پیاپی 67، مهر 2026، صفحه 250-259    اصل مقاله (777.02 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2026.106378.2262
نویسندگان
Nehal Gamal Elsayed* 1؛ Doaa Abdelhady Hassan1؛ Nabila Hassan Ahmed2؛ Mohamed Ibrahim Soliman3؛ Amira Elwan1
1Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2Tropical Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
3Zagazig Army Forced Oncology Center, Zagazig, Egypt
چکیده
Background: Deep inspiration breath-hold (DIBH) technique is superior to the free breathing (FB) in irradiation of breast and chest wall. The radiation exposure of liver, lungs and heart is decreased considerably when right breast cancer (RBC) is treated with DIBH. The present study aimed to reduce the toxicity of RBC irradiation to risk organs.
Method: This prospective clinical study included 120 female patients who were randomly allocated into 2 Arms, arm A received FB, arm B received DIBH, each compromising 60cases. The comparison of both arms, treatment plans evaluation and dose volume histograms were analyzed to assess doses to clinical target volume (CTV), boost and risk organs (liver, ipsilateral lung and heart). A study of alanine transaminase (ALT) and aspartate transaminase (AST) as pre, during and 3 months post-treatment were done. Statistical Package of Social Services version 24 was used to analyze data. Statistical analysis was determined using the chi square and Mann-Whitney U test and P ≤ 0.05 was considered statistically significant. 
Results: The mean, minimum and maximum doses of CTV and boost in both arms showed no significant difference. Mean, minimum and maximum doses of liver and right lung in both arms showed significant difference, doses in DIBH technique were less than FB. Mean and maximum doses of heart in both arms showed significant difference, while the minimum dose of heart did not. Pre-, during, and 3 months post-treatment ALT and AST values showed no significant difference.
Conclusion: In RBC patients DIBH is an efficient method for lowering liver, ipsilateral lung and heart radiation exposure. 

تازه های تحقیق

Nabila Hassan Ahmed (google scholar)

Amira Elwan (google scholar)

کلیدواژه‌ها
Breast neoplasms؛ Deep inspiration breath hold؛ Radiotherapy؛ Dose reduction
مراجع

1. Azim HA, Elghazawy H, Ghazy RM, Abdelaziz AH, Abdelsalam M, Elzorkany A, et al. Clinicopathologic features of breast cancer in Egypt-contemporary profile and future needs: A systematic review and meta-analysis. JCO Glob Oncol. 2023;9:e2200387. doi: 10.1200/GO. 22.00387. PMID: 36888929; PMCID: PMC10497263.
2. El-Kassas M, Ezzat R, Shousha H, Bosson-Amedenu S, Ouerfelli N. Mapping cancer in Egypt: a model to predict future cancer situation using estimates from GLOBOCAN 2020. Egypt J Intern Med. 2025;37: 31.doi: 10.1186/s43162-025-00412-1.
3. Hussein A, Talima S, Ali AS. Dosimetric comparison of deep inspiratory breath hold versus free breathing plans in locoregional radiotherapy in breast cancer patients. Neuroquantology. 2022; 20(9): 6826-38. doi: 10.14754/nq.2022.20.9.NQ44798.
4. Aznar MC, Carrasco de Fez P, Corradini S, Mast M, McNair H, Meattini I, et al. ESTRO-ACROP guideline: Recommendations on implementation of breath-hold techniques in radiotherapy. Radiother Oncol. 2023;185:109734. doi: 10.1016/j.radonc.2023.109734. PMID: 37301263.
5. Park HJ, Cheong KH, Koo T, Lee MY, Kim KJ, Park S, et al. Effects of radiation dose on liver after free-breathing volumetric modulated arc therapy for breast cancer. In Vivo. 2022;36(4):1937-43. doi: 10.21873/ invivo.12915. PMID: 35738635; PMCID: PMC9301413.
6. Haji G, Nabizade U, Kazimov K, Guliyeva N, Isayev I. Liver dose reduction by deep inspiration breath hold technique in right-sided breast irradiation. Radiat Oncol J. 2019;37(4):254-8 . doi: 10.3857/roj.2019.00206. PMID: 31918462; PMCID: PMC6952711.
7. Rice L, Harris S, Green MM, Price PM. Deep inspiration breath-hold (DIBH) technique applied in right breast radiotherapy to minimize liver radiation. BJR Case Rep. 2015;1(2):20150038. doi: 10.1259/bjrcr.20150038. PMID: 30363168; PMCID: PMC6159123.
8. Semiz V, Aydin B, Gulsan D, Ataç E, Ozkaya E, Kinay S, et al. The effect of deep inspiration breath-hold technique on right coronary artery, heart, and liver doses in right breast cancer radiotherapy. Int J RadiatOncolBiol Phys. 2023; 117(2):e640.doi:10.1016/j. ijrobp.2023.06.2048.
9. Essers M, Poortmans PM, Verschueren K, Hol S, Cobben DC. Should breathing adapted radiotherapy also be applied for right-sided breast irradiation? Acta Oncol. 2016; 55(4):460-5. doi: 10.3109/02841 86X.2015.1102321. PMID: 26503610.
10. Conway JL, Conroy L, Harper L, Scheifele M, Li H, Smith WL, et al. Deep inspiration breath- hold produces a clinically meaningful reduction in ipsilateral lung dose during locoregional radiation therapy for some women with right-sided breast cancer. Pract Radiat Oncol. 2017;7(3):147-53. doi: 10.1016/j.prro.2016. 10.011. PMID: 28089480.
11. Koay EJ, Owen D, Das P. Radiation-induced liver disease and modern radiotherapy. Semin Radiat Oncol. 2018; 28(4):321-31. doi: 10.1016/j.semradonc. 2018.06.007. PMID: 30309642; PMCID: PMC 6402843.
12. Rades D, Cremers F, Janssen S, Bartscht T, Kristiansen C, Timke C, et al. Association between mean lung dose and prevalence of radiation pneumonitis in elderly lung cancer patients. Anticancer Res. 2024; 44(5) 2073-9. doi: 10.21873/anticanres.17011. PMID: 38677766.
13. Darby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Brønnum D, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013;14; 368(11):987-98. doi: 10.1056/NEJMoa1209825. PMID: 23484825.
14. Mader T, Pace R, da Silva RT, Adam EJ, Näf G, Winter CC, et al. Deep inspirational breast hold (DIBH) for right breast irradiation: Improved sparing of liver and lung tissue. Clin Transl Radiat Oncol. 2024;45:100731. doi: 10.1016/j.ctro.2024.100731. PMID: 38304241; PMCID: PMC10832365.
15. Borgonovo G, Paulicelli E, Daniele D, Presilla S, Richetti A, Valli M. Deep inspiration breath hold in post-operative radiotherapy for right breast cancer: a retrospective analysis. Rep Pract Oncol Radiother. 2022; 27(4):717-23.doi: 10.5603/RPOR.a2022.0085 . PMID: 36196427; PMCID: PMC9521696.
16. Chatterjee S, Chakraborty S, Moses A, Nallathambi C, Mahata A, Mandal S, et al. Resource requirements and reduction in cardiac mortality from deep inspiration breath hold (DIBH) radiation therapy for left sided breast cancer patients: a prospective service development analysis. Pract Radiat Oncol. 2018; 8(6):382-7. doi: 10.1016/j.prro.2018.03.007. PMID: 29699893.
17. Gallant F, Jagsi R. Deep inspiration breath hold for cardiac sparing: No deep pockets required. JACC Cardio Oncol. 2024; 6(4):526-8. doi: 10.1016/ j.jaccao.2024.06.003.

آمار
تعداد مشاهده مقاله: 63
تعداد دریافت فایل اصل مقاله: 54


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب