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Elsayed, Nehal, Hassan, Doaa, Ahmed, Nabila, Soliman, Mohamed, Elwan, Amira. (1405). Dose Sparing with Breath-Holding Compared with Free Breathing in Right Sided Breast Cancer Irradiation. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/mejc.2026.106378.2262
Nehal Gamal Elsayed; Doaa Abdelhady Hassan; Nabila Hassan Ahmed; Mohamed Ibrahim Soliman; Amira Elwan. "Dose Sparing with Breath-Holding Compared with Free Breathing in Right Sided Breast Cancer Irradiation". سامانه مدیریت نشریات علمی, , , 1405, -. doi: 10.30476/mejc.2026.106378.2262
Elsayed, Nehal, Hassan, Doaa, Ahmed, Nabila, Soliman, Mohamed, Elwan, Amira. (1405). 'Dose Sparing with Breath-Holding Compared with Free Breathing in Right Sided Breast Cancer Irradiation', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/mejc.2026.106378.2262
Elsayed, Nehal, Hassan, Doaa, Ahmed, Nabila, Soliman, Mohamed, Elwan, Amira. Dose Sparing with Breath-Holding Compared with Free Breathing in Right Sided Breast Cancer Irradiation. سامانه مدیریت نشریات علمی, 1405; (): -. doi: 10.30476/mejc.2026.106378.2262

Dose Sparing with Breath-Holding Compared with Free Breathing in Right Sided Breast Cancer Irradiation

Middle East Journal of Cancer
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 10 تیر 1405    اصل مقاله (461.35 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2026.106378.2262
نویسندگان
Nehal Gamal Elsayed* 1؛ Doaa Abdelhady Hassan1؛ Nabila Hassan Ahmed2؛ Mohamed Ibrahim Soliman3؛ Amira Elwan1
1Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2Tropical Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
3Zagazig Army Forced Oncology Center, Zagazig, Egypt
چکیده
Background: Deep inspiration breath-hold (DIBH) technique is superior to the free breathing (FB) in irradiation of breast and chest wall. The radiation exposure of liver, lungs and heart is decreased considerably when right breast cancer (RBC) is treated with DIBH. The present study aimed to reduce the toxicity of RBC irradiation to risk organs.
Method: This prospective clinical study included 120 female patients who were randomly allocated into 2 Arms, arm A received FB, arm B received DIBH, each compromising 60cases. The comparison of both arms, treatment plans evaluation and dose volume histograms were analyzed to assess doses to clinical target volume (CTV), boost and risk organs (liver, ipsilateral lung and heart). A study of alanine transaminase (ALT) and aspartate transaminase (AST) as pre, during and 3 months post-treatment were done. Statistical Package of Social Services version 24 was used to analyze data. Statistical analysis was determined using the chi square and Mann-Whitney U test and P ≤ 0.05 was considered statistically significant. 
Results: The mean, minimum and maximum doses of CTV and boost in both arms showed no significant difference. Mean, minimum and maximum doses of liver and right lung in both arms showed significant difference, doses in DIBH technique were less than FB. Mean and maximum doses of heart in both arms showed significant difference, while the minimum dose of heart did not. Pre, during and 3 months post-treatment ALT and AST values showed no significant difference.
Conclusion: In RBC patients DIBH is an efficient method for lowering liver, ipsilateral lung and heart radiation exposure. 

تازه های تحقیق

Nabila Hassan Ahmed (google scholar)

Amira Elwan (google scholar)

کلیدواژه‌ها
Breast neoplasms؛ Deep inspiration breath hold؛ Radiotherapy؛ Dose reduction
مراجع
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