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RAMLI HAMID, MARLINA, Rahmat, Kartini, Sayed Abul Khair, Syarifah Muna-Izzati, Teoh, Kean, Fadzli, Farhana, Nawawi, Ouzreiah, Mohd Ramli, Norlisah, Rozalli, Faizatul, See, Mee. (1405). Differentiating Benign from Malignant Papillary Breast Lesions: Insights from a Multi-Modality Imaging Approach. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/mejc.2026.106143.2257
MARLINA TANTY RAMLI HAMID; Kartini Rahmat; Syarifah Muna-Izzati Sayed Abul Khair; Kean Hooi Teoh; Farhana Fadzli; Ouzreiah Nawawi; Norlisah Mohd Ramli; Faizatul Izz Rozalli; Mee Hoong See. "Differentiating Benign from Malignant Papillary Breast Lesions: Insights from a Multi-Modality Imaging Approach". سامانه مدیریت نشریات علمی, , , 1405, -. doi: 10.30476/mejc.2026.106143.2257
RAMLI HAMID, MARLINA, Rahmat, Kartini, Sayed Abul Khair, Syarifah Muna-Izzati, Teoh, Kean, Fadzli, Farhana, Nawawi, Ouzreiah, Mohd Ramli, Norlisah, Rozalli, Faizatul, See, Mee. (1405). 'Differentiating Benign from Malignant Papillary Breast Lesions: Insights from a Multi-Modality Imaging Approach', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/mejc.2026.106143.2257
RAMLI HAMID, MARLINA, Rahmat, Kartini, Sayed Abul Khair, Syarifah Muna-Izzati, Teoh, Kean, Fadzli, Farhana, Nawawi, Ouzreiah, Mohd Ramli, Norlisah, Rozalli, Faizatul, See, Mee. Differentiating Benign from Malignant Papillary Breast Lesions: Insights from a Multi-Modality Imaging Approach. سامانه مدیریت نشریات علمی, 1405; (): -. doi: 10.30476/mejc.2026.106143.2257

Differentiating Benign from Malignant Papillary Breast Lesions: Insights from a Multi-Modality Imaging Approach

Middle East Journal of Cancer
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 10 تیر 1405    اصل مقاله (476.68 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2026.106143.2257
نویسندگان
MARLINA TANTY RAMLI HAMID* 1؛ Kartini Rahmat2؛ Syarifah Muna-Izzati Sayed Abul Khair3؛ Kean Hooi Teoh4؛ Farhana Fadzli3؛ Ouzreiah Nawawi3؛ Norlisah Mohd Ramli3؛ Faizatul Izz Rozalli3؛ Mee Hoong See5
1Department of Radiology, University Teknologi MARA, Sungai Buloh Campus, Selangor, Malaysia
2Department of Biomedical Imaging, University Malaya Research Imaging Centre, Kuala Lumpur, Malaysia.
3Department of Biomedical Imaging, University Malaya Research Imaging Centre, Kuala Lumpur, Malaysia
4Department of Pathology, University Malaya Medical Centre, Kuala Lumpur, Malaysia
5Department of Surgery, University Malaya Medical Centre, Kuala Lumpur, Malaysia
چکیده
Background: Papillary breast lesions are a heterogeneous group of breast lesions with overlapping benign and malignant imaging features, often posing diagnostic and management challenges. The present study aimed to evaluate the imaging characteristics of papillary breast lesions using ultrasound (US), mammography, and magnetic resonance imaging (MRI), and to correlate these findings with histopathological results to identify features predictive of malignancy.
Method: In this retrospective observational study, we reviewed clinical, imaging, and pathological data from 168 women with 188 histologically confirmed papillary breast lesions treated at a tertiary center from 2009 to 2019. Imaging features were assessed using the American College of Radiology Breast Imaging Reporting and Data System (ACR BI-RADS) lexicon. Statistical analysis was performed using IBM SPSS Statistics for Windows, Version 25.0 (IBM Corp., Armonk, NY). Mann–Whitney U test and Pearson chi-squared test were used to investigate group differences, and binary logistic regression was applied to evaluate associations. A P <0.05 was considered statistically significant.
Results: Malignant lesions were significantly larger in size (median >10 mm, P < 0.001), and more likely to exhibit non-circumscribed margins, internal vascularity, posterior acoustic features, and non-parallel orientation on US. Mammographic features significantly associated with malignancy included irregular shape and non-circumscribed margins (P < 0.05). MRI features predictive of malignancy included irregular shape, non-circumscribed margins, heterogeneous enhancement, and non-mass enhancement, although the small MRI sample size limits the generalizability of the study results.
Conclusion: Specific imaging features on US, mammography, and MRI may help distinguish malignant from benign papillary breast lesions. Given the notable upgrade rate upon excision, surgical removal is recommended for lesions with atypical or indeterminate features.

تازه های تحقیق

Marlina Tanty Ramli Hamid (google scholar)

کلیدواژه‌ها
Breast neoplasms؛ Biopsy؛ Diagnostic imaging؛ Magnetic resonance imaging؛ Mammography
مراجع
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