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| تعداد نشریات | 20 |
| تعداد شمارهها | 1,266 |
| تعداد مقالات | 11,542 |
| تعداد مشاهده مقاله | 81,988,918 |
| تعداد دریافت فایل اصل مقاله | 121,118,724 |
Effect of Fat-Soluble Vitamins on Osteogenic and Odontogenic Differentiation of Dental Mesenchymal Stem Cells: A Systematic Review | ||
| Journal of Dentistry | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 19 اردیبهشت 1405 اصل مقاله (549.86 K) | ||
| نوع مقاله: Systematic Review | ||
| شناسه دیجیتال (DOI): 10.30476/dentjods.2026.109695.2907 | ||
| نویسندگان | ||
| Parinaz Kalejahi1؛ Katayoun Katebi2؛ Atefeh Abedi3؛ Fatemeh Salehnia4؛ Mohammad Amin Mehrali3؛ Neda Yasamineh* 5 | ||
| 1Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 2Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 3Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 4Research Center for Evidence Based Medicine (RCEBM), Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 5Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. | ||
| چکیده | ||
| Background: Tissue engineering–based regenerative approaches are rapidly expanding in dentistry, particularly within endodontics, where dental mesenchymal stem cells play a pivotal role. Fat-soluble vitamins have been proposed as potential modulators of osteogenic and odontogenic differentiation. Purpose: This systematic review aimed to evaluate the effects of fat-soluble vitamins on the osteogenic and odontogenic differentiation of dental mesenchymal stem cells. Materials and Method: A comprehensive search was conducted in Web of Science, PubMed, Scopus, and Embase, using predefined keywords, from database inception to the last search date. Two independent reviewers screened titles, abstracts, and full texts according to the PRISMA guidelines. Additional studies were identified through manual searches of reference lists, relevant conference proceedings, and academic theses. Studies investigating the impact of fat-soluble vitamins on osteogenic and/or odontogenic differentiation of DMSCs were included. Results: The search yielded 1,124 records, of which 13 studies met the inclusion criteria. Among the included studies, nine investigated the effects of vitamin D, two evaluated vitamin A, two assessed vitamin K, and one examined vitamin E. Overall, the included evidence suggests that fat-soluble vitamins can enhance osteogenic and odontogenic differentiation markers in various types of dental mesenchymal stem cells, although the extent and mechanisms varied across studies. Conclusion: Fat-soluble vitamins demonstrate promising adjunctive effects in promoting osteogenic and odontogenic differentiation of dental mesenchymal stem cells. However, heterogeneity in study methodologies and outcomes highlights the need for standardized experimental designs and further mechanistic research to clarify their potential clinical applicability. | ||
| کلیدواژهها | ||
| Vitamins؛ Mesenchymal Stem Cells؛ Osteogenesis؛ Odontogenesis؛ Tissue Engineering | ||
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آمار تعداد مشاهده مقاله: 3 تعداد دریافت فایل اصل مقاله: 2 |
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