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Aminishakib, Pooyan, Hosseini, Seyed Mohammadmoein, Yaghmaie, Marjan, Modaressi, Alireza, Tabatabaei, Saba Sadat, Pashaiefar, Hossein. (1405). Hybrid Central Odontogenic Fibroma with Central Giant Cell Granuloma: A Systematic Review and a Report of a Challenging Case. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/dentjods.2026.109295.2870
Pooyan Aminishakib; Seyed Mohammadmoein Hosseini; Marjan Yaghmaie; Alireza Modaressi; Saba Sadat Tabatabaei; Hossein Pashaiefar. "Hybrid Central Odontogenic Fibroma with Central Giant Cell Granuloma: A Systematic Review and a Report of a Challenging Case". سامانه مدیریت نشریات علمی, , , 1405, -. doi: 10.30476/dentjods.2026.109295.2870
Aminishakib, Pooyan, Hosseini, Seyed Mohammadmoein, Yaghmaie, Marjan, Modaressi, Alireza, Tabatabaei, Saba Sadat, Pashaiefar, Hossein. (1405). 'Hybrid Central Odontogenic Fibroma with Central Giant Cell Granuloma: A Systematic Review and a Report of a Challenging Case', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/dentjods.2026.109295.2870
Aminishakib, Pooyan, Hosseini, Seyed Mohammadmoein, Yaghmaie, Marjan, Modaressi, Alireza, Tabatabaei, Saba Sadat, Pashaiefar, Hossein. Hybrid Central Odontogenic Fibroma with Central Giant Cell Granuloma: A Systematic Review and a Report of a Challenging Case. سامانه مدیریت نشریات علمی, 1405; (): -. doi: 10.30476/dentjods.2026.109295.2870

Hybrid Central Odontogenic Fibroma with Central Giant Cell Granuloma: A Systematic Review and a Report of a Challenging Case

Journal of Dentistry
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 19 اردیبهشت 1405    اصل مقاله (555.01 K)
نوع مقاله: Case Report
شناسه دیجیتال (DOI): 10.30476/dentjods.2026.109295.2870
نویسندگان
Pooyan Aminishakib1؛ Seyed Mohammadmoein Hosseini* 2؛ Marjan Yaghmaie3؛ Alireza Modaressi4؛ Saba Sadat Tabatabaei2؛ Hossein Pashaiefar5
1Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
2School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
3Hematology, Oncology &Stem Cell Transplantation Research Center, Research institution for Oncology, Hematology and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran.
4Fellowship (Oral and Maxillofacial Oncology), Assistant Professor, Department of Oral and Maxillofacial Surgery, School of Dentistry, Islamic Azad University Tehran Medical Sciences, Tehran, Iran.
5Dr. Yaghmaei Clinical Genetics Laboratory, Tehran, Iran.
چکیده
Central odontogenic fibroma (COdF) is a rare benign tumor originating from odontogenic mesenchyme; a subset of cases exhibits hybrid features, particularly with central giant cell granuloma (CGCG). This study presents a rare case of epithelium-rich COdF associated with CGCG and a systematic review of this type of hybrid lesion. We report a 10-year-old male with a unilateral mandibular swelling and a progressively enlarging radiolucent lesion. Imaging and histopathological evaluation identified a benign mixed odontogenic tumor with epithelial-rich COdF features and multinucleated giant cells. Genetic testing for the SH3BP2 gene mutation, commonly associated with cherubism, was negative. Surgical resection and reconstruction were performed, with no recurrence observed at a 1-year follow-up. A review was conducted on hybrid COdF/CGCG lesions in PubMed, Embase, Scopus, Web of Science, and Wiley Online. Analyzing clinical, radiographic, and histopathological patterns, our findings highlight the necessity of molecular and histopathological differentiation for accurate diagnosis and treatment planning.
کلیدواژه‌ها
Odontogenic Tumors؛ Jaw Neoplasms؛ SH3BP2 protein؛ Systematic review
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