پیوندهای مفید
آمار
| تعداد نشریات | 20 |
| تعداد شمارهها | 1,266 |
| تعداد مقالات | 11,540 |
| تعداد مشاهده مقاله | 81,960,921 |
| تعداد دریافت فایل اصل مقاله | 121,091,853 |
Marine-derived plastic-binding peptides | ||
| Trends in Pharmaceutical Sciences and Technologies | ||
| مقاله 2، دوره 12، شماره 1، خرداد 2026 | ||
| نوع مقاله: Brief Report | ||
| شناسه دیجیتال (DOI): 10.30476/tips.2025.109390.1329 | ||
| نویسندگان | ||
| Nastaran Nikkholgh1؛ Zohreh Ghanbarzadeh2؛ Shiva Hemmati* 3 | ||
| 1Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 2Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 3Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, I.R. Iran. | ||
| چکیده | ||
| Peptides can be used as reagents in enzyme-linked immunosorbent assays (ELISA), in which the sample is immobilized on a solid support, usually a polystyrene plate. Polystyrene-binding peptides allow site-specific immobilization of proteins or antibodies directly onto polystyrene (PS) plates with minimal conformational change. Additionally, micro- and nanoplastics pose a significant threat to all life forms in the environment, and the development of biosensors for their detection is considered a pressing need in the field. PS is also used as a support in solid-phase peptide synthesis. In this brief report, we analyzed 3505 marine-derived peptides using machine-learning algorithms to introduce novel and putative PS-binding peptides. Seven strong candidates, mainly derived from Conus species, were the most optimal PS-binders. PS-binder peptides were cationic or cationic amphipathic, composed of helical structures. π-π stacking, hydrophobic, and electrostatic interactions were involved in the attachment of peptides to plastics. Some PS-binding peptides were identified to be active against pathogenic bacteria, making them promising candidates as biomaterials to prevent medical device-related infections. Taken together, the novel identified peptides are suggested as a capturing reagent on PS surfaces for biomedical applications. | ||
| کلیدواژهها | ||
| Bioactive peptides؛ Biomaterial؛ Immobilization؛ Polystyrene؛ Solid-phase peptide synthesis | ||
|
آمار تعداد مشاهده مقاله: 2 |
||