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Tjahjani, Susy, Hermanto, Faizal, Muchtaridi, Muchtaridi, Aulifa, Diah Lia, Haq, Fahmi Ahsanul. (1405). Synergistic Antimalarial Activity of Alpha-Mangostin Chitosan Alginate Nanoparticles with Chloroquine in Mice Infected with Plasmodium berghei: The Potential of a New Antimalarial Drug Combination. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijms.2025.108518.4347
Susy Tjahjani; Faizal Hermanto; Muchtaridi Muchtaridi; Diah Lia Aulifa; Fahmi Ahsanul Haq. "Synergistic Antimalarial Activity of Alpha-Mangostin Chitosan Alginate Nanoparticles with Chloroquine in Mice Infected with Plasmodium berghei: The Potential of a New Antimalarial Drug Combination". سامانه مدیریت نشریات علمی, , , 1405, -. doi: 10.30476/ijms.2025.108518.4347
Tjahjani, Susy, Hermanto, Faizal, Muchtaridi, Muchtaridi, Aulifa, Diah Lia, Haq, Fahmi Ahsanul. (1405). 'Synergistic Antimalarial Activity of Alpha-Mangostin Chitosan Alginate Nanoparticles with Chloroquine in Mice Infected with Plasmodium berghei: The Potential of a New Antimalarial Drug Combination', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijms.2025.108518.4347
Tjahjani, Susy, Hermanto, Faizal, Muchtaridi, Muchtaridi, Aulifa, Diah Lia, Haq, Fahmi Ahsanul. Synergistic Antimalarial Activity of Alpha-Mangostin Chitosan Alginate Nanoparticles with Chloroquine in Mice Infected with Plasmodium berghei: The Potential of a New Antimalarial Drug Combination. سامانه مدیریت نشریات علمی, 1405; (): -. doi: 10.30476/ijms.2025.108518.4347

Synergistic Antimalarial Activity of Alpha-Mangostin Chitosan Alginate Nanoparticles with Chloroquine in Mice Infected with Plasmodium berghei: The Potential of a New Antimalarial Drug Combination

Iranian Journal of Medical Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 07 اردیبهشت 1405    اصل مقاله (472.79 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2025.108518.4347
نویسندگان
Susy Tjahjani* 1؛ Faizal Hermanto2؛ Muchtaridi Muchtaridi3؛ Diah Lia Aulifa3؛ Fahmi Ahsanul Haq2
1Department of Parasitology, Faculty of Medicine, Maranatha Christian University (Universitas Kristen Maranatha), Bandung, Indonesia
2Department of Pharmacology, Faculty of Pharmacy, Universitas Jenderal Achmad Yani, Bandung, Indonesia
3Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran (Unpad), Bandung, Indonesia
چکیده
Background: Malaria drug resistance is one of the leading causes of malaria-related morbidity and mortality worldwide. Alpha-mangostin exhibits antimalarial and antioxidant activity in vitro. The soluble alpha-mangostin chitosan alginate nanoparticles (ACAN) exhibit proper antimalarial activity in vivo. This study aimed to explore the antimalarial activity of the chloroquine-ACAN combination and the interaction between them in various ratios. 
Methods: A 4-day suppressive test, according to Peter’s test, was conducted using P. berghei-inoculated Swiss Webster mice in Bandung, 2024. It was done for six different concentrations (in triplicate) of three kinds of the combinations respectively i.e.: ½ effective dose 50 (ED50) ACAN:½ED50 chloroquine (ratio-1, ACAN and chloroquine were used in a weight ratio of 189:1), ¼ ED50 ACAN:¾ ED50 chloroquine (ratio-2, weight ratio of 63:1), ¾ ED50 ACAN:¼ ED50 chloroquine (ratio-3, weight ratio of 567:1) to find out growth inhibitory percentage of each concentration. ED50 of each combination was determined using probit analysis in IBM SPSS Statistics 27 software. The sum of fractional effective dose 50 (∑FED50) was determined using a specific formula. ∑FED50 indicates the kind of interaction: <1, >1, or =1 means synergistic, antagonistic, or additive. 
Results: ED50 of ratio-1 (ACAN/Chloroquine weight ratio 189/1), ratio-2 (weight ratio 63/1), ratio-3 (weight ratio 567/1) is 9.196, 7.626, 82.13 mg/Kg BW (<100 mg/Kg BW). ∑FED50 of ratio-1, ratio-2, and ratio-3 is 0.069, 0.113, and 0.414 (far below 1).
Conclusion: ACAN-chloroquine exhibits good and marked synergistic antimalarial activity, especially in a ratio-1. It offers a glimmer of hope for future research to combat and ultimately eliminate malaria. 

تازه های تحقیق

Susy Tjahjani (Google Scholar)

کلیدواژه‌ها
Chloroquine؛ Xanthones؛ Nanoparticles؛ Antimalaria
مراجع
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