LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,262
تعداد مقالات11,503
تعداد مشاهده مقاله81,855,803
تعداد دریافت فایل اصل مقاله120,988,738
Dode, Aparna, Guduru, Srikanth, Singareddy, Rohith, N.V.N., Madhusudhana Sresty, Gudipudi, Deleep Kumar. (1405). Dosimetric Evaluation of Two Linac-Based Stereotactic Radiosurgery Approaches in the Management of Single Brain Metastasis. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/mejc.2026.107219.2286
Aparna Dode; Srikanth Guduru; Rohith Singareddy; Madhusudhana Sresty N.V.N.; Deleep Kumar Gudipudi. "Dosimetric Evaluation of Two Linac-Based Stereotactic Radiosurgery Approaches in the Management of Single Brain Metastasis". سامانه مدیریت نشریات علمی, , , 1405, -. doi: 10.30476/mejc.2026.107219.2286
Dode, Aparna, Guduru, Srikanth, Singareddy, Rohith, N.V.N., Madhusudhana Sresty, Gudipudi, Deleep Kumar. (1405). 'Dosimetric Evaluation of Two Linac-Based Stereotactic Radiosurgery Approaches in the Management of Single Brain Metastasis', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/mejc.2026.107219.2286
Dode, Aparna, Guduru, Srikanth, Singareddy, Rohith, N.V.N., Madhusudhana Sresty, Gudipudi, Deleep Kumar. Dosimetric Evaluation of Two Linac-Based Stereotactic Radiosurgery Approaches in the Management of Single Brain Metastasis. سامانه مدیریت نشریات علمی, 1405; (): -. doi: 10.30476/mejc.2026.107219.2286

Dosimetric Evaluation of Two Linac-Based Stereotactic Radiosurgery Approaches in the Management of Single Brain Metastasis

Middle East Journal of Cancer
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 10 تیر 1405    اصل مقاله (752.48 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2026.107219.2286
نویسندگان
Aparna Dode* 1؛ Srikanth Guduru2؛ Rohith Singareddy3؛ Madhusudhana Sresty N.V.N.4؛ Deleep Kumar Gudipudi3
1Department of Physics, University college of science, Osmania University Hyderabad, Telangana, India
2Department of Radiation physics, Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, Telangana, India
3Department of Radiation Oncology, Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, Telangana, India
4Department of Radiation Physics, Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, Telangana, India
چکیده
Background: Stereotactic radiosurgery (SRS) relies on precise, highly conformal radiation with sharp dose falloff to protect adjacent normal brain tissue. Differences in multileaf collimator (MLC) configuration and planning system algorithms can affect dosimetric performance and delivery efficiency, supporting the need for comparative assessment of current techniques. The present study aimed to compare the dosimetric parameters and treatment efficiency of SRS plans using RapidArc with an HD120 MLC against volumetric modulated arc therapy (VMAT) using the Agility-MLC in patients diagnosed with a single brain metastasis.
Method: In this retrospective dosimetric study of 12 patients who received single‑fraction 22 Gy SRS for single brain metastasis, paired treatment plans were generated for each case: (i) a RapidArc plan in Eclipse with an HD120‑MLC and (ii) a VMAT plan in Monaco with an Agility‑MLC. Target coverage, conformity index, homogeneity index, gradient index (GI), and organ‑at‑risk (OAR) doses were compared alongside efficiency indicators monitor units (MUs) and beam‑on time (BOT). Paired t‑tests performed in SPSS v28.0 by international business machines (IBM) determined statistical significance, with P < 0.05 considered significant.
Results: Both techniques achieved acceptable target coverage and met OAR constraints. RapidArc showed significantly improved gross tumor volume (GTV) homogeneity (P = 0.00047), lower GI (P = 0.04238), and lower normal brain volume receiving at least 12Gy (V12Gy, P = 0.005). VMAT plans required fewer MUs (P = 0.011) and had shorter BOT (P = 0.04), indicating improved efficiency. No significant differences were observed in maximum doses to the brainstem, optic apparatus, and cochlea.
Conclusion: Both RapidArc and VMAT delivered clinically acceptable SRS plans. In our patient population RapidArc offered superior homogeneity and better sparing of normal brain tissue.

تازه های تحقیق

Aparna Dode (google scholar)

Deleep Kumar Gudipudi (google scholar)

کلیدواژه‌ها
Stereotactic radiosurgery؛ Brain neoplasms؛ Radiotherapy planning؛ Intensity-modulated؛ Organs at risk
مراجع
  1. Peña-Pino I, Chen CC. Stereotactic radiosurgery as treatment for brain metastases: An update. Asian J Neurosurg. 2023;18(2):246-57. doi: 10.1055/s-0043-1769754. PMID: 37397044; PMCID: PMC10310446.
  2. Brown PD, Jaeckle K, Ballman KV, Farace E, Cerhan JH, Anderson SK, et al. Effect of radiosurgery alone vs radiosurgery with whole brain radiation therapy on cognitive function in patients with 1 to 3 brain metastases: A randomized clinical trial. 2016;316(4):401-9. doi: 10.1001/jama.2016.9839. Erratum in: JAMA. 2018;320(5):510. doi: 10.1001/jama.2018.9890. PMID: 27458945; PMCID: PMC5313044.
  3. Liu H, Andrews DW, Evans JJ, Werner-Wasik M, Yu Y, Dicker AP, et al. Plan quality and treatment efficiency for radiosurgery to multiple brain metastases: Non-coplanar RapidArc vs. Gamma knife. Front Oncol. 2016;6:26. doi: 10.3389/fonc.2016.00026. PMID: 26904504; PMCID: PMC4749694.
  4. Lin X, DeAngelis LM. Treatment of brain metastases. J Clin Oncol. 2015;33(30):3475-84. doi: 10.1200/JCO.2015.60.9503. PMID: 26282648; PMCID: PMC5087313.
  5. Gupta RK, Bharti S, Kunhare N, Sahu Y, Pathik N. Brain tumor detection and classification using cycle generative adversarial networks. Interdiscip Sci. 2022;14(2):485-502. doi: 10.1007/s12539-022-00502-6. Erratum in: Interdiscip Sci. 2022;14(2):503. doi: 10.1007/s12539-022-00507-1. PMID: 35137330.
  6. Spaniol M, Mai S, Zakrzewski T, Ehmann M, Stieler F. Inverse planning in Gamma Knife radiosurgery: A comparative planning study. Phys Med. 2021;82:269-78. doi:10.1016/j.ejmp.2021.02.019. PMID: 33706117.
  7. Abramian D, Blystad I, Eklund A. Evaluation of inverse treatment planning for gamma knife radiosurgery using fMRI brain activation maps as organs at risk. Med Phys. 2023;50(9):5297-311. doi:10.1002/mp.16660. PMID: 37531209.
  8. Duan Y, Cao H, Wu B, Wu Y, Liu D, Zhou L, et al. Dosimetric comparison, treatment efficiency estimation, and biological evaluation of popular stereotactic radiosurgery options in treating single small brain metastasis. Front Oncol. 2021;11:716152. doi:10.3389/fonc.2021.716152. PMID: 34540686; PMCID: PMC8447903.
  9. Abacioglu U, Ozen Z, Yilmaz M, Kaygusuz G, Tuncel B, Tuger N, et al. Critical appraisal of RapidArc radiosurgery with flattening filter free photon beams for benign brain lesions in comparison to Gamma Knife: A treatment planning study. Radiat Oncol. 2014;9:119. doi:10.1186/1748-717X-9-119. PMID: 24993394; PMCID: PMC4097054.
  10. Doxsee K, Paddick I, Friedman WA, Li JG, De Leo A, Koch M, et al. A comparison of radiosurgical planning techniques for the treatment of trigeminal neuralgia. Pract Radiat Oncol. 2025;15(3):e258-e266. doi:10.1016/j.prro.2024.11.014. Erratum in: Pract Radiat Oncol. 2025;15(4): e300. doi:10.1016/j.prro.2025.01.002. PMID: 38420527; PMCID: PMC10486789.
  11. Deodato F, Cilla S, Macchia G, Torre G, Caravatta L, Mariano G, et al. Stereotactic radiosurgery (SRS) with volumetric modulated arc therapy (VMAT): Interim results of a multi-arm phase I trial (DESTROY-2). Clin Oncol (R Coll Radiol). 2014;26(12):748-56. doi:10.1016/j.clon.2014.08.005. PMID: 25175042.
  12. Tawfik ZA, Farid ME-A, El Shahat KM, Hussein AA, Al Etreby M. Approaches for stereotactic radiosurgery (SRS)/stereotactic radiotherapy (SRT) in brain metastases using different radiotherapy modalities (feasibility study). J Xray Sci Technol. 2024;32(3):765-81. doi:10.3233/XST-230275. PMID: 38277334.
  13. Narayanasamy G, Saenz D, Cruz W, Ha CS, Papanikolaou N, Stathakis S, et al. Commissioning an Elekta Versa HD linear accelerator. J Appl Clin Med Phys. 2016;17(1):179-91. doi:10.1120/jacmp.v17i1.5799. PMID: 26894351; PMCID: PMC5690217.
  14. Meshram MN, Pramanik S, Ranjith CP, Gopal SK, Dobhal R. Dosimetric properties of equivalent-quality flattening filter-free (FFF) and flattened photon beams of Versa HD linear accelerator. J Appl Clin Med Phys. 2016;17(3):358-70. doi:10.1120/jacmp.v17i3.6173. PMID: 27167293; PMCID: PMC5690903.
  15. Shaw E, Scott C, Souhami L, Dinapoli R, Kline R, Loeffler J, et al. Single-dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG Protocol 90-05. Int J Radiat Oncol Biol Phys. 2000;47(2):291-8. doi:10.1016/S0360-3016(99)00507-6. PMID: 10675125; PMCID: PMC2807730.
  16. Mrozowska M, Kukołowicz P. Relationships between various indices of dose distribution homogeneity. Rep Pract Oncol Radiother. 2015;20(4):278-83. doi:10.1016/j.rpor.2015.03.007. PMID: 26109915; PMCID: PMC4477127.
  17. Menon SV, Paramu R, Bhasi S, Nair RK. Evaluation of plan quality metrics in stereotactic radiosurgery/radiotherapy in the treatment plans of arteriovenous malformations. J Med Phys. 2018;43(4):214-20. doi:10.4103/jmp.JMP_25_18. PMID: 30636846; PMCID: PMC6299748.
  18. Simon M, Papp J, Csiki E, Kovács Á. Plan quality assessment of fractionated stereotactic radiotherapy treatment plans in patients with brain metastases. Front Oncol. 2022; 12:846609. doi:10.3389/fonc.2022.846609. PMID: 35345445; PMCID: PMC8957100.
  19. Taylor M, Williams J, Gleason JF Jr. Effects of multileaf collimator design and function when using an optimized dynamic conformal arc approach for stereotactic radiosurgery treatment of multiple brain metastases with a single isocenter: A planning study. 2020;12(8):e9833. doi:10.7759/cureus.9833. PMID: 32832305; PMCID: PMC7437117.
  20. Lai Y, Chen S, Xu C, Shi L, Fu L, Ha H, et al. Dosimetric superiority of flattening filter free beams for single-fraction stereotactic radiosurgery in single brain metastasis. 2017;8(21):35272-9. doi:10.18632/oncotarget.13085. PMID: 27823985; PMCID: PMC5471053.
  21. Prendergast BM, Fiveash JB, Popple RA, et al. Flattening filter-free linac improves treatment delivery efficiency in stereotactic body radiation therapy. J Appl Clin Med Phys. 2013;14(3):4126. doi:10.1120/jacmp.v14i3.4126. PMID: 23652246; PMCID: PMC5714408.
  22. Andrevska A, Knight KA, Sale CA. The feasibility and benefits of using volumetric arc therapy in patients with brain metastases: A systematic review. J Med Radiat Sci. 2014;61(4):267-76. doi:10.1002/jmrs.69. PMID: 25598981; PMCID: PMC4282127.
 

آمار
تعداد مشاهده مقاله: 1
تعداد دریافت فایل اصل مقاله: 1


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب