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Guduru, Srikanth, Singareddy, Rohith, NVN, Madhusudhana Sresty, Gudipudi, Deleep Kumar, Dode, Aparna. (1405). Dosimetric Evaluation of Two LINAC-Based Stereotactic Radiosurgery Approaches in the Management of Single Brain Metastasis. سامانه مدیریت نشریات علمی, 17(3), 234-242. doi: 10.30476/mejc.2026.107219.2286
Srikanth Guduru; Rohith Singareddy; Madhusudhana Sresty NVN; Deleep Kumar Gudipudi; Aparna Dode. "Dosimetric Evaluation of Two LINAC-Based Stereotactic Radiosurgery Approaches in the Management of Single Brain Metastasis". سامانه مدیریت نشریات علمی, 17, 3, 1405, 234-242. doi: 10.30476/mejc.2026.107219.2286
Guduru, Srikanth, Singareddy, Rohith, NVN, Madhusudhana Sresty, Gudipudi, Deleep Kumar, Dode, Aparna. (1405). 'Dosimetric Evaluation of Two LINAC-Based Stereotactic Radiosurgery Approaches in the Management of Single Brain Metastasis', سامانه مدیریت نشریات علمی, 17(3), pp. 234-242. doi: 10.30476/mejc.2026.107219.2286
Guduru, Srikanth, Singareddy, Rohith, NVN, Madhusudhana Sresty, Gudipudi, Deleep Kumar, Dode, Aparna. Dosimetric Evaluation of Two LINAC-Based Stereotactic Radiosurgery Approaches in the Management of Single Brain Metastasis. سامانه مدیریت نشریات علمی, 1405; 17(3): 234-242. doi: 10.30476/mejc.2026.107219.2286

Dosimetric Evaluation of Two LINAC-Based Stereotactic Radiosurgery Approaches in the Management of Single Brain Metastasis

Middle East Journal of Cancer
مقاله 5، دوره 17، شماره 3 - شماره پیاپی 67، مهر 2026، صفحه 234-242    اصل مقاله (1.54 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2026.107219.2286
نویسندگان
Srikanth Guduru1؛ Rohith Singareddy2؛ Madhusudhana Sresty NVN1؛ Deleep Kumar Gudipudi2؛ Aparna Dode* 3
1Department of Radiation Physics, Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, Telangana, India
2Department of Radiation Oncology, Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, Telangana, India
3Department of Physics, University College of Science, Osmania University Hyderabad, Telangana, India
چکیده
Background: Stereotactic radiosurgery (SRS) relies on precise, highly conformal radiation with sharp dose falloff to protect adjacent normal brain tissue. Differences in multileaf collimator (MLC) configuration and planning system algorithms can affect dosimetric performance and delivery efficiency, supporting the need for comparative assessment of current techniques. The present study aimed to compare the dosimetric parameters and treatment efficiency of SRS plans using RapidArc with an HD120 MLC against volumetric modulated arc therapy (VMAT) using the Agility-MLC in patients diagnosed with a single brain metastasis.
Method: In this retrospective dosimetric study of 12 patients who received single‑fraction 22 Gy SRS for single brain metastasis, paired treatment plans were generated for each case: (i) a RapidArc plan in Eclipse with an HD120‑MLC and (ii) a VMAT plan in Monaco with an Agility‑MLC. Target coverage, conformity index, homogeneity index, gradient index (GI), and organ‑at‑risk (OAR) doses were compared alongside efficiency indicators monitor units (MUs) and beam‑on time (BOT). Paired t‑tests performed in SPSS v28.0 by international business machines determined statistical significance, with P < 0.05 considered significant.
Results: Both techniques achieved acceptable target coverage and met OAR constraints. RapidArc showed significantly improved gross tumor volume homogeneity (P = 0.00047), lower GI (P = 0.04238), and lower normal brain volume receiving at least 12Gy (V12Gy, P = 0.005). VMAT plans required fewer MUs (P = 0.011) and had shorter BOT (P = 0.04), indicating improved efficiency. No significant differences were observed in maximum doses to the brainstem, optic apparatus, and cochlea.
Conclusion: Both RapidArc and VMAT delivered clinically acceptable SRS plans. In our patient population RapidArc offered superior homogeneity and better sparing of normal brain tissue.

تازه های تحقیق

Aparna Dode (google scholar)

Deleep Kumar Gudipudi (google scholar)

کلیدواژه‌ها
Stereotactic radiosurgery؛ Brain neoplasms؛ Radiotherapy planning؛ Intensity-modulated؛ Organs at risk
مراجع
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