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F, Andrea, RB, Devi Krishna, Krishnamurthy, Nandini, Murali, Sanjana, R, Ramya, Ganesan, Nalini, Paul, Solomon. (1405). Breast Cancer Susceptibility Genes in Estrogen Receptor Signaling Pathway in a Southern Indian Population. سامانه مدیریت نشریات علمی, 17(3), 272-282. doi: 10.30476/mejc.2026.104819.2208
Andrea Mary F; Devi Krishna RB; Nandini Krishnamurthy; Sanjana Murali; Ramya R; Nalini Ganesan; Solomon FD Paul. "Breast Cancer Susceptibility Genes in Estrogen Receptor Signaling Pathway in a Southern Indian Population". سامانه مدیریت نشریات علمی, 17, 3, 1405, 272-282. doi: 10.30476/mejc.2026.104819.2208
F, Andrea, RB, Devi Krishna, Krishnamurthy, Nandini, Murali, Sanjana, R, Ramya, Ganesan, Nalini, Paul, Solomon. (1405). 'Breast Cancer Susceptibility Genes in Estrogen Receptor Signaling Pathway in a Southern Indian Population', سامانه مدیریت نشریات علمی, 17(3), pp. 272-282. doi: 10.30476/mejc.2026.104819.2208
F, Andrea, RB, Devi Krishna, Krishnamurthy, Nandini, Murali, Sanjana, R, Ramya, Ganesan, Nalini, Paul, Solomon. Breast Cancer Susceptibility Genes in Estrogen Receptor Signaling Pathway in a Southern Indian Population. سامانه مدیریت نشریات علمی, 1405; 17(3): 272-282. doi: 10.30476/mejc.2026.104819.2208

Breast Cancer Susceptibility Genes in Estrogen Receptor Signaling Pathway in a Southern Indian Population

Middle East Journal of Cancer
مقاله 9، دوره 17، شماره 3 - شماره پیاپی 67، مهر 2026، صفحه 272-282    اصل مقاله (1.22 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2026.104819.2208
نویسندگان
Andrea Mary F* 1؛ Devi Krishna RB1؛ Nandini Krishnamurthy1؛ Sanjana Murali1؛ Ramya R2؛ Nalini Ganesan3؛ Solomon FD Paul1
1Department of Human Genetics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India
2Department of Surgery, Apollo Institute of Medical Sciences and Research, Chittor, Andhra Pradesh, India
3Department of Biochemistry, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India
چکیده
Background: Ovarian cancer starts in the ovaries and is hard to detect early due to vague symptoms. The present study aimed to investigate whether the ESR1 gene is linked to breast cancer. Also, we aimed to examine whether genetic changes in the ESR1 gene affect breast cancer risk through estrogen binding.
Method: A hospital‑based case–control study was conducted with 200 breast cancer patients and 200 age‑matched healthy controls. Peripheral blood samples were collected, and genomic DNA was extracted using standard protocols. ESR1 gene variants were genotyped by real‑time polymerase chain reaction. Allele and genotype frequencies were compared, and risk was estimated by statically.
Results: The C/C genotype of the PvuII site in the ESR1 gene showed a significant link to breast cancer risk. No association was found for the AG/GG genotype of theXbaI polymorphism. The TG and GG genotypes of rs2881766 showed a weak risk increase.
Conclusion: The rs2234693 variation is linked to breast cancer risk, suggesting its potential for genetic screening and personalized therapy. No significant link was found for other variations, highlighting rs2234693 for future research.

تازه های تحقیق

Andrea Mary F (google scholar)

Devi Krishna RB (google scholar)

کلیدواژه‌ها
Breast neoplasm؛ Estrogen receptor؛ Polymorphism؛ Genetic؛ Genotype
مراجع
  1. Wilkinson L, Gathani T. Understanding breast cancer as a global health concern. Br J Radiol. 2022;95(1130):20211033. doi: 10.1259/bjr.20211033. PMID: 34905391; PMCID: PMC8822551.
  2. Obeagu EI, Obeagu GU. Breast cancer: A review of risk factors and diagnosis. Medicine (Baltimore). 2024;103(3):e36905. doi: 10.1097/MD.0000000000036905. PMID: 38241592; PMCID: PMC10798762.
  3. Mehrotra R, Yadav K. Breast cancer in India: Present scenario and the challenges ahead. World J Clin Oncol. 2022;13(3):209-18. doi: 10.5306/wjco.v13.i3.209. PMID: 35433294; PMCID: PMC8966510.
  4. Crooke PS, Justenhoven C, Brauch H; GENICA Consortium; Dawling S, Roodi N, et al. Estrogen metabolism and exposure in a genotypic-phenotypic model for breast cancer risk prediction. Cancer Epidemiol Biomarkers Prev. 2011;20(7):1502-15. doi: 10.1158/1055-9965.EPI-11-0060. PMID: 21610218; PMCID: PMC3472969.
  5. Yoshidome K, Shibata MA, Couldrey C, Korach KS, Green JE. Estrogen promotes mammary tumor development in C3(1)/SV40 large T-antigen transgenic mice: paradoxical loss of estrogen receptoralpha expression during tumor progression. Cancer Res. 2000;60(24):6901-10. PMID: 11156389.
  6. Mallepell S, Krust A, Chambon P, Brisken C. Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland. Proc Natl Acad Sci U S A. 2006;103(7):2196-201. doi: 10.1073/pnas.0510974103. PMID: 16452162; PMCID: PMC1413744.
  7. Rusidzé M, Adlanmérini M, Chantalat E, Raymond-Letron I, Cayre S, Arnal JF, et al. Estrogen receptor-α signaling in post-natal mammary development and breast cancers. Cell Mol Life Sci. 2021;78(15):5681-705. doi: 10.1007/s00018-021-03860-4. PMID: 34156490; PMCID: PMC8316234.
  8. Karsono R, Haryono SJ, Karsono B, Harahap WA, Pratiwi Y, Aryandono T. ESR1 PvuII polymorphism: from risk factor to prognostic and predictive factor of the success of primary systemic therapy in advanced breast cancer. BMC Cancer. 2021;21(1):1348. doi: 10.1186/s12885-021-09083-x. PMID: 34930150; PMCID: PMC8686387.
  9. Eldafira E, Prasasty VD, Abinawanto A, Syahfirdi L, Pujianto DA. Polymorphisms of estrogen receptor-α and estrogen receptor-β genes and its expression in endometriosis. Turk J Pharm Sci. 2021;18(1):91-5. doi: 10.4274/tjps.galenos.2019.94914. PMID: 33634683; PMCID: PMC7957307.
  10. Dunning AM, Healey CS, Baynes C, Maia AT, Scollen S, Vega A, et al. Association of ESR1 gene tagging SNPs with breast cancer risk. Hum Mol Genet. 2009;18(6):1131-9. doi: 10.1093/hmg/ddn429. PMID: 19126777; PMCID: PMC2722230.
  11. Wieser F, Schneeberger C, Tong D, Tempfer C, Huber JC, Wenzl R. PROGINS receptor gene polymorphism is associated with endometriosis. Fertil Steril. 2002;77:309-12. doi: 10.1016/S0015-0282(01)02975-4.
  12. Tan GC, Chu C, Lee YT, Tan CCK, Ashburner J, Wood NW, et al. The influence of microsatellite polymorphisms in sex steroid receptor genes ESR1, ESR2 and AR on sex differences in brain structure. Neuroimage. 2020;221:117087. doi: 10.1016/j.neuroimage.2020.117087. PMID: 32593802; PMCID: PMC8960998.
  13. Yaşar P, Ayaz G, User SD, Güpür G, Muyan M. Molecular mechanism of estrogen-estrogen receptor signaling. Reprod Med Biol. 2016;16(1):4-20. doi: 10.1002/rmb2.12006. PMID: 29259445; PMCID: PMC5715874.
  14. Montazeri-Najafabady N, Dabbaghmanesh MH. Association of estrogen receptor alpha gene PvuII and XbaI polymorphisms with obesity-related phenotypes and body composition in Iranian children and adolescents: a cross-sectional study. Egypt J Med Hum Genet. 2025;26(48). doi: 10.1186/s43042-025-00678-8.
  15. Ganguly S, Naik D, Muskara A, Mian OY. The nexus of endocrine signaling and cancer: How steroid hormones influence genomic stability. Endocrinology. 2021;162(1):bqaa177. doi: 10.1210/endocr/bqaa177. PMID: 33260197; PMCID: PMC7707372.
  16. Dall GV, Britt KL. Estrogen effects on the mammary gland in early and late life and breast cancer risk. Front Oncol. 2017;7:110. doi: 10.3389/fonc.2017.00110. PMID: 28603694; PMCID: PMC5445118.
  17. Zhu J, Zhou Y, Jin B, Shu J. Role of estrogen in the regulation of central and peripheral energy homeostasis: from a menopausal perspective. Ther Adv Endocrinol Metab. 2023;14:20420188231199359. doi: 10.1177/20420188231199359.PMID: 37719789; PMCID: PMC10504839.
  18. Khan NU, Khan H, Alanzi AR, Chen T. Association of ESR1, HER1, and HER2 polymorphisms with breast cancer risk in the KP population: a case-control study. J Mammary Gland Biol Neoplasia. 2025;30(1):6. doi: 10.1007/s10911-025-09500-3.
  19. Zhang ZL, Zhang CZ, Li Y, Zhao ZH, Yang SE. Association between ERα gene Pvu II polymorphism and breast cancer susceptibility: A meta-analysis. Medicine (Baltimore). 2018;97(17):e0317. doi: 10.1097/MD.0000000000010317.PMID: 29702977; PMCID: PMC5944501.
  20. Smolarz B, Nowak AZ, Bryś M, Forma E, Łukasiewicz H, Samulak D, et al. Analysis of single nucleotide polymorphisms (SNPs) rs2234693 and rs9340799 of the ESR1 gene and the risk of breast cancer. In Vivo. 2024;38(5):2134-43. doi: 10.21873/invivo.14237.PMID: 39187368; PMCID: PMC11363788.
  21. Al-Amri RJ, Alotibi MK, Al-Raddadi RI, Shebli WT, Fallatah EI, Alhujaily AS, et al. Estrogen receptor 1 gene (ESR1) rs2234693 polymorphism and breast cancer risk in Saudi women. Asian Pac J Cancer Prev. 2020;21(11):3235-40. doi: 10.31557/APJCP.2020.21.11.3235.PMID: 33247680; PMCID: PMC8033134.
  22. Son BH, Kim MK, Yun YM, Kim HJ, Yu JH, Ko BS, et al. Genetic polymorphism of ESR1 rs2881766 increases breast cancer risk in Korean women. J Cancer Res Clin Oncol. 2015;141(4):633-45. doi: 10.1007/s00432-014-1849-2.PMID: 25323936; PMCID: PMC11823984.
  23. Dai Z, Tian T, Wang M, Yang T, Li H, Lin S, et al. Genetic polymorphisms of estrogen receptor genes are associated with breast cancer susceptibility in Chinese women. Cancer Cell Int. 2019;19:11. doi: 10.1186/s12935-019-0727-z.PMID: 30636932; PMCID: PMC6325673.
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