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Wu, Han, Wang, Zhiling, Gu, Fang. (1405). Association of Serum Cotinine with Hyperuricemia in American Adolescents: A Cross-Sectional Study. سامانه مدیریت نشریات علمی, 51(4), 256-265. doi: 10.30476/ijms.2025.107138.4148
Han Wu; Zhiling Wang; Fang Gu. "Association of Serum Cotinine with Hyperuricemia in American Adolescents: A Cross-Sectional Study". سامانه مدیریت نشریات علمی, 51, 4, 1405, 256-265. doi: 10.30476/ijms.2025.107138.4148
Wu, Han, Wang, Zhiling, Gu, Fang. (1405). 'Association of Serum Cotinine with Hyperuricemia in American Adolescents: A Cross-Sectional Study', سامانه مدیریت نشریات علمی, 51(4), pp. 256-265. doi: 10.30476/ijms.2025.107138.4148
Wu, Han, Wang, Zhiling, Gu, Fang. Association of Serum Cotinine with Hyperuricemia in American Adolescents: A Cross-Sectional Study. سامانه مدیریت نشریات علمی, 1405; 51(4): 256-265. doi: 10.30476/ijms.2025.107138.4148

Association of Serum Cotinine with Hyperuricemia in American Adolescents: A Cross-Sectional Study

Iranian Journal of Medical Sciences
مقاله 4، دوره 51، شماره 4، تیر 2026، صفحه 256-265    اصل مقاله (685.75 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2025.107138.4148
نویسندگان
Han Wu1؛ Zhiling Wang2؛ Fang Gu* 3
1Department of Clinical Laboratory Medicine, Sir Run Run Shaw Hospital Xiasha Campus, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, 310018, China
2Wenzhou Medical University, Wenzhou, 325035, Zhejiang Province, China
3Center for Reproductive Medicine, Department of Pediatrics, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang Province, 310018, China
چکیده
Background: Cotinine is a known harmful toxicant, while its relationship with hyperuricemia in adolescents remains unclear. This study aimed to analyze the relationship between serum cotinine concentration and hyperuricemia among US adolescents aged 12-19 years. 
Methods: This cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. Eligible participants were adolescents (12-19 years) with complete data for serum cotinine and uric acid. Out of 61,125 total participants during the study period, 6,831 participants were included in the analysis. The independent variable was serum cotinine, and the outcome was hyperuricemia. Multiple logistic regression analyses were performed to assess the relationship between serum cotinine and hyperuricemia, and sensitivity analyses were performed from multiple perspectives. 
Results: The study population comprised 6,831 individuals. The mean age of the participants was 15.5±2.3 years, 52.3% were men, and 28.6% were non-Hispanic white. Participants with hyperuricemia were more likely to be older (15.9±2.3 years vs. 15.1±2.2 years), male (56.9% vs. 43.1%), and non-Hispanic white (32.8%). The adjusted odds ratio of hyperuricemia associated with a unit increase in serum cotinine was 1.07 (95% CI: 1.01-1.13). This association remained consistent across subgroups and sensitivity analyses.
Conclusion: This study suggested an association between serum cotinine concentration and hyperuricemia in American adolescents. This modifiable risk factor warrants further investigation as a potential target for mitigating hyperuricemia in this population.

تازه های تحقیق

Han Wu (Google Scholar) 

Fang Gu (Google Scholar) 

کلیدواژه‌ها
Serum cotinine؛ Hyperuricemia؛ Nutrition surveys؛ Adolescent؛ Cross-sectional studies
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