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Assadiasl, Sara, Soleimanifar, Narjes, Alamolhoda, Mohammad Hassan, Mojtahedi, Hanieh, Sadr, Maryam, Safdel, Sepehr, Mozooni, Zahra, Nicknam, Mohammad Hossein. (1405). Naïve, Effector, and Memory T cells Frequency in the Peripheral Blood of Healthy Men Following 4 Weeks of Intermittent Fasting. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijns.2026.107883.1528
Sara Assadiasl; Narjes Soleimanifar; Mohammad Hassan Alamolhoda; Hanieh Mojtahedi; Maryam Sadr; Sepehr Safdel; Zahra Mozooni; Mohammad Hossein Nicknam. "Naïve, Effector, and Memory T cells Frequency in the Peripheral Blood of Healthy Men Following 4 Weeks of Intermittent Fasting". سامانه مدیریت نشریات علمی, , , 1405, -. doi: 10.30476/ijns.2026.107883.1528
Assadiasl, Sara, Soleimanifar, Narjes, Alamolhoda, Mohammad Hassan, Mojtahedi, Hanieh, Sadr, Maryam, Safdel, Sepehr, Mozooni, Zahra, Nicknam, Mohammad Hossein. (1405). 'Naïve, Effector, and Memory T cells Frequency in the Peripheral Blood of Healthy Men Following 4 Weeks of Intermittent Fasting', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijns.2026.107883.1528
Assadiasl, Sara, Soleimanifar, Narjes, Alamolhoda, Mohammad Hassan, Mojtahedi, Hanieh, Sadr, Maryam, Safdel, Sepehr, Mozooni, Zahra, Nicknam, Mohammad Hossein. Naïve, Effector, and Memory T cells Frequency in the Peripheral Blood of Healthy Men Following 4 Weeks of Intermittent Fasting. سامانه مدیریت نشریات علمی, 1405; (): -. doi: 10.30476/ijns.2026.107883.1528

Naïve, Effector, and Memory T cells Frequency in the Peripheral Blood of Healthy Men Following 4 Weeks of Intermittent Fasting

International Journal of Nutrition Sciences
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 18 فروردین 1405    اصل مقاله (1.07 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/ijns.2026.107883.1528
نویسندگان
Sara Assadiasl1؛ Narjes Soleimanifar2؛ Mohammad Hassan Alamolhoda3؛ Hanieh Mojtahedi2؛ Maryam Sadr2؛ Sepehr Safdel2؛ Zahra Mozooni4؛ Mohammad Hossein Nicknam2، 5
1Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran ~ Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran
2Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
3Research Center of Quran, Hadith and Medicine, Tehran University of Medical Sciences, Tehran, Iran
4Institute of Immunology and Infectious Diseases, Antimicrobial Resistance Research Center, Iran University of Medical Sciences, Tehran, Iran
5Department of Immunology, Medicine School, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: Intermittent fasting (IF) is a 16/8 fasting model, which is supposed to recruit immune cells to the bone marrow, thus prevents immune exhaustion. The aim of this study was to compare the frequency of naive, memory, and effector T lymphocytes in blood circulation before and after IF.
Methods: Proportion of CD4+CXCR7+45RA+ (naïve T cells), CD4+CXCR7+45RA- (memory T cells), and CD4+CXCR7- 45RA- (effector T cells) cells were evaluated in 18 healthy young men in the week before and on the last day of Ramadan fasting, resembling IF, using
flowcytometry.
Results: The percentage of peripheral blood naïve T cells reduced significantly at the end of Ramadan fasting (p=0.001); however, the frequency of memory and effector T cells did not change.
Conclusion: The decreased number of circulatory naïve T cells suggests a protective effect of intermittent fasting on immunosenescence and immune exhaustion. Also, preserved proportion of effector T cells is suggestive of an intact immunocompetence despite 4 weeks of IF.
کلیدواژه‌ها
Fasting؛ Memory T cells؛ Naïve T cells؛ Effector T cells
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