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The Impact of High-Fat Diet-Induced Obesity on Erythropoietin (EPO) level in Rat Model | ||
| International Journal of Nutrition Sciences | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 18 فروردین 1405 اصل مقاله (361.13 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/ijns.2026.107886.1532 | ||
| نویسندگان | ||
| Kimia Sharifian-Amiry1؛ Roghayeh Pourbagher2؛ Maryam Elmi* 2؛ Hossein Khaleghzadeh-Ahangar3، 4؛ Sima Shahabi5، 4 | ||
| 1Student Research Committee, School of Medicine, Babol University of Medical Sciences, Babol, Iran | ||
| 2Research Center of Cellular and Molecular Biology, Health Research Center, Babol University of Medical Sciences, Babol, Iran | ||
| 3Department of Physiology, School of Medicine, Health Research Center, Babol University of Medical Sciences, Babol, Iran | ||
| 4Immuno-Regulation Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran | ||
| 5Department of Physiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran; Immunoregulation Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran | ||
| چکیده | ||
| Background: Obesity is a multifactorial disease that is associated with various metabolic syndromes. Erythropoietin (EPO), traditionally recognized for its role in red blood cell production, has been identified as a pleiotropic hormone with diverse physiological functions. The aim of this study was to investigate how high-fat diet obesity in rat model influenced the level of EPO in both serum and brain tissues. Methods: Twenty adult male Wistar rats were randomly divided into two groups and weighed. The control group received a standard diet, while the experimental group was fed a high-fat diet (2.5% olive oil, 1% cholesterol, and 1% cholic acid as meals to the special rodent diet) for 30 days. Blood and brain tissue samples were collected at the end of the study. EPO level in serum and brain homogenates were measured using enzyme-linked immunosorbent assay (ELISA). Results: The obese group showed significant weight gain compared to control. Serum EPO level in obese rats was significantly lower than the control group. In contrast, brain EPO level was higher in obese group than in the control group, though it was not significant. Furthermore, in the obese group, brain EPO concentration was significantly higher than the serum EPO level, while in control, brain EPO was lower than serum EPO, but without significant difference. Conclusion: Our findings have important implications for understanding the dual role of EPO in peripheral and central metabolic regulation during obesity. Enhancing brain EPO signaling or increasing systemic EPO to appropriate levels might offer new therapeutic for obesity and related metabolic disorders. | ||
| کلیدواژهها | ||
| Diet؛ Obesity؛ Erythropoietin؛ Brain؛ Rat | ||
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آمار تعداد مشاهده مقاله: 4 تعداد دریافت فایل اصل مقاله: 2 |
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