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Ghasemi, Younes. (1404). Distant Origins of Local Pathologies: Rethinking the Systemic Roots of Alzheimer’s Disease and Beyond. سامانه مدیریت نشریات علمی, 51(3), 157-159. doi: 10.30476/ijms.2026.51601
Younes Ghasemi. "Distant Origins of Local Pathologies: Rethinking the Systemic Roots of Alzheimer’s Disease and Beyond". سامانه مدیریت نشریات علمی, 51, 3, 1404, 157-159. doi: 10.30476/ijms.2026.51601
Ghasemi, Younes. (1404). 'Distant Origins of Local Pathologies: Rethinking the Systemic Roots of Alzheimer’s Disease and Beyond', سامانه مدیریت نشریات علمی, 51(3), pp. 157-159. doi: 10.30476/ijms.2026.51601
Ghasemi, Younes. Distant Origins of Local Pathologies: Rethinking the Systemic Roots of Alzheimer’s Disease and Beyond. سامانه مدیریت نشریات علمی, 1404; 51(3): 157-159. doi: 10.30476/ijms.2026.51601

Distant Origins of Local Pathologies: Rethinking the Systemic Roots of Alzheimer’s Disease and Beyond

Iranian Journal of Medical Sciences
مقاله 1، دوره 51، شماره 3، خرداد 2026، صفحه 157-159    اصل مقاله (188.47 K)
نوع مقاله: Editorial
شناسه دیجیتال (DOI): 10.30476/ijms.2026.51601
نویسنده
Younes Ghasemi* 1، 2
1Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
2Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Alzheimer’s disease appears to be a neurological condition; however, much of its underlying pathology may originate from distant systems outside the brain.
کلیدواژه‌ها
Alzheimer’s disease؛ Cerebral disorder؛ Gut-brain axis؛ Dysbiosis
مراجع
  1. Peng L, Zhang Z, Li Q, Song Z, Yan C, Ling H. Unveiling the multifaceted pathogenesis and therapeutic drugs of Alzheimer’s disease: A comprehensive review. Heliyon. 2024;10:e39217. doi: 10.1016/j.heliyon.2024.e39217. PubMed PMID: 39629139; PubMed Central PMCID: PMC11612466.
    Song D, Li Y, Yang LL, Luo YX, Yao XQ. Bridging systemic metabolic dysfunction and Alzheimer’s disease: the liver interface. Mol Neurodegener. 2025;20:61. doi: 10.1186/s13024-025-00849-6. PubMed PMID: 40437610; PubMed Central PMCID: PMC12121119.
    Kearns R. Gut-Brain Axis and Neuroinflammation: The Role of Gut Permeability and the Kynurenine Pathway in Neurological Disorders. Cell Mol Neurobiol. 2024;44:64. doi: 10.1007/s10571-024-01496-z. PubMed PMID: 39377830; PubMed Central PMCID: PMC11461658.
    Xie J, Van Hoecke L, Vandenbroucke RE. The Impact of Systemic Inflammation on Alzheimer’s Disease Pathology. Front Immunol. 2021;12:796867. doi: 10.3389/fimmu.2021.796867. PubMed PMID: 35069578; PubMed Central PMCID: PMC8770958.
    Sait AM, Day PJR. Interconnections between the Gut Microbiome and Alzheimer’s Disease: Mechanisms and Therapeutic Potential. Int J Mol Sci. 2024;25. doi: 10.3390/ijms25168619. PubMed PMID: 39201303; PubMed Central PMCID: PMC11354889.
    Wu B, Liu Y, Li H, Zhu L, Zeng L, Zhang Z, et al. Liver as a new target organ in Alzheimer’s disease: insight from cholesterol metabolism and its role in amyloid-beta clearance. Neural Regen Res. 2025;20:695-714. doi: 10.4103/1673-5374.391305. PubMed PMID: 38886936; PubMed Central PMCID: PMC11433892. 
    Rahimpour S, Clary BL, Nasoohi S, Berhanu YS, Brown CM. Immunometabolism In Brain Aging and Neurodegeneration: Bridging Metabolic Pathways and Immune Responses. Aging Dis. 2024;16:3361-80. doi: 10.14336/ad.2024.1293. PubMed PMID: 39751865; PubMed Central PMCID: PMC12539545. 
    Zhang W, Xiao D, Mao Q, Xia H. Role of neuroinflammation in neurodegeneration development. Signal Transduct Target Ther. 2023;8:267. doi: 10.1038/s41392-023-01486-5. PubMed PMID: 37433768; PubMed Central PMCID: PMC10336149. 
    Berriat F, Lobsiger CS, Boillée S. The contribution of the peripheral immune system to neurodegeneration. Nat Neurosci. 2023;26:942-54. doi: 10.1038/s41593-023-01323-6. PubMed PMID: 37231108.
    Mroke P, Goit R, Rizwan M, Tariq S, Rizwan AW, Umer M, et al. Implications of the Gut Microbiome in Alzheimer’s Disease: A Narrative Review. Cureus. 2024;16:e73681. doi: 10.7759/cureus.73681. PubMed PMID: 39677207; PubMed Central PMCID: PMC11646158.
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تعداد مشاهده مقاله: 32
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