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Dong, Hu, Hu, Jiwen, Chen, Wei. (1405). The Influence of Harmonic Ratio on HIFU-Induced Thermal Lesion Formation in Biological Tissue. سامانه مدیریت نشریات علمی, 16(2), 109-130. doi: 10.31661/jbpe.v0i0.2502-1889
Hu Dong; Jiwen Hu; Wei Chen. "The Influence of Harmonic Ratio on HIFU-Induced Thermal Lesion Formation in Biological Tissue". سامانه مدیریت نشریات علمی, 16, 2, 1405, 109-130. doi: 10.31661/jbpe.v0i0.2502-1889
Dong, Hu, Hu, Jiwen, Chen, Wei. (1405). 'The Influence of Harmonic Ratio on HIFU-Induced Thermal Lesion Formation in Biological Tissue', سامانه مدیریت نشریات علمی, 16(2), pp. 109-130. doi: 10.31661/jbpe.v0i0.2502-1889
Dong, Hu, Hu, Jiwen, Chen, Wei. The Influence of Harmonic Ratio on HIFU-Induced Thermal Lesion Formation in Biological Tissue. سامانه مدیریت نشریات علمی, 1405; 16(2): 109-130. doi: 10.31661/jbpe.v0i0.2502-1889

The Influence of Harmonic Ratio on HIFU-Induced Thermal Lesion Formation in Biological Tissue

Journal of Biomedical Physics and Engineering
دوره 16، شماره 2 - شماره پیاپی 1، تیر 2026، صفحه 109-130    اصل مقاله (1.54 M)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2502-1889
نویسندگان
Hu Dong* 1؛ Jiwen Hu2؛ Wei Chen3
1School of Information Science and Engineering, Changsha Normal University, Changsha 410100, China
2School of Mathematics and Physics, Nanhua University, Hengyang, 421001, China
3School of Electronic Information and Electrical Engineering, Changsha University, Changsha, 410022, China
چکیده
Background: High-Intensity Focused Ultrasound (HIFU) is a non-invasive therapeutic technique, widely used for thermal ablation of tumors and other pathological tissues. The formation of thermal lesions during HIFU therapy is influenced by nonlinear acoustic effects, including the generation of harmonics and harmonic ratios.
Objective: This study aimed to investigate the influence of the harmonic ratio on HIFU-induced thermal lesion formation in biological tissue. A coupled acoustic-thermal model is developed to simulate HIFU wave propagation and temperature elevation, incorporating nonlinear acoustic effects and dynamic tissue properties.
Material and Methods: This numerical study investigates the influence of the harmonic ratio (R*=(P3+P4)/P2) on HIFU-induced thermal lesion formation in liver tissue. A coupled acoustic-thermal model was developed to simulate the propagation of HIFU waves and the resulting temperature elevation in tissue. The model incorporates nonlinear acoustic effects and dynamic tissue properties. The relationship between harmonic ratio, focal temperature, and thermal lesion size was analyzed through numerical simulation.
Results: The results demonstrate that the harmonic ratio significantly affects the spatial distribution of acoustic energy deposition and the resulting thermal lesion size. Specifically, below 50 °C, the harmonic ratio decreases with rising focal temperature; above 50 °C, the harmonic ratio increases, indicating a turning point at the thermal denaturation threshold of liver tissue. Furthermore, higher harmonic ratio values correlate with larger thermal lesions, suggesting that higher-harmonic components enhance energy deposition in the focal region. 
Conclusion: These findings provide insights into optimizing HIFU therapy by controlling harmonic ratio generation, thereby improving treatment efficacy and safety.

تازه های تحقیق

Hu Dong (PubMed)

کلیدواژه‌ها
High-Intensity Focused Ultrasound Ablation؛ Acoustic Energy؛ Thermal Denaturation؛ Ultrasonic Therapy؛ Nonlinear Dynamics
مراجع
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