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Narimani, Omid, Javdani Shahedin, Golshid, Ashrafi Tamai, Iradj, Bakhtiari, Ali Akbar, Mazaheri Nezhad Fard, Ramin. (1404). Emerging Resistance of Filamentous Bacteria in the Oral Cavity of HIV-Positive Patients in Tehran, Iran. سامانه مدیریت نشریات علمی, 51(3), 209-217. doi: 10.30476/ijms.2025.106890.4138
Omid Narimani; Golshid Javdani Shahedin; Iradj Ashrafi Tamai; Ali Akbar Bakhtiari; Ramin Mazaheri Nezhad Fard. "Emerging Resistance of Filamentous Bacteria in the Oral Cavity of HIV-Positive Patients in Tehran, Iran". سامانه مدیریت نشریات علمی, 51, 3, 1404, 209-217. doi: 10.30476/ijms.2025.106890.4138
Narimani, Omid, Javdani Shahedin, Golshid, Ashrafi Tamai, Iradj, Bakhtiari, Ali Akbar, Mazaheri Nezhad Fard, Ramin. (1404). 'Emerging Resistance of Filamentous Bacteria in the Oral Cavity of HIV-Positive Patients in Tehran, Iran', سامانه مدیریت نشریات علمی, 51(3), pp. 209-217. doi: 10.30476/ijms.2025.106890.4138
Narimani, Omid, Javdani Shahedin, Golshid, Ashrafi Tamai, Iradj, Bakhtiari, Ali Akbar, Mazaheri Nezhad Fard, Ramin. Emerging Resistance of Filamentous Bacteria in the Oral Cavity of HIV-Positive Patients in Tehran, Iran. سامانه مدیریت نشریات علمی, 1404; 51(3): 209-217. doi: 10.30476/ijms.2025.106890.4138

Emerging Resistance of Filamentous Bacteria in the Oral Cavity of HIV-Positive Patients in Tehran, Iran

Iranian Journal of Medical Sciences
مقاله 5، دوره 51، شماره 3، خرداد 2026، صفحه 209-217    اصل مقاله (1003.71 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2025.106890.4138
نویسندگان
Omid Narimani1؛ Golshid Javdani Shahedin2؛ Iradj Ashrafi Tamai3؛ Ali Akbar Bakhtiari4؛ Ramin Mazaheri Nezhad Fard* 1
1Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
2Department of Research and Development, Production and Research Complex, Pasteur Institute of Iran, Tehran, Iran
3Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
4Department of Microbiology, Islamic Azad University Medical Branch of Tehran, Tehran, Iran
چکیده
Background: In general, human immunodeficiency virus (HIV) weakens the immune system, making patients prone to oral infections such as gum and dental diseases. Filamentous bacteria (actinomycetes) can multiply in these patients, leading to treatment-resistant infections. Routine antimicrobial drugs such as penicillin G, amoxicillin, and tetracycline are widely used for treatment. However, antibiotic resistance is rapidly increasing worldwide. Therefore, the major target of the present study was to assess the prevalence and antibiotic susceptibility of filamentous bacteria in the oral cavity of HIV-positive patients in Tehran, Iran.
Methods: In this cross-sectional study, oral swabs were collected from 205 HIV-positive patients in an academic behavioral disease clinic, Tehran, Iran, and immediately transported to the laboratory under cold chain conditions. Bacterial cultures were prepared on differentiate media, and primary identification was carried out using biochemical and microscopic assays. Furthermore, deoxyribonucleic acid (DNA) extraction was carried out for molecular identification of the bacterial isolates using 16S rRNA (ribosomal ribonucleic acid) sequencing and polymerase chain reaction (PCR). Antimicrobial susceptibility of the isolates was assessed using the disk diffusion method for selected antimicrobials.
Results: In general, filamentous bacteria were identified in 5.3% of HIV-positive patients, including Nocardia (2.9%) and Streptomyces (2.4%) species. Molecular identification and biochemical assessments verified these findings. The highest prevalence rate of the bacteria was observed in males (74.1%) and individuals aged 41–60 years. Phylogenetic analysis revealed significant genetic similarities in the identified strains. These bacteria were susceptible to trimethoprim-sulfamethoxazole but resistant to other antimicrobials.
Conclusion: In conclusion, filamentous bacteria such as Nocardia and Streptomyces species show high prevalence rates in HIV-positive patients. Accurate identification using molecular techniques and antimicrobial susceptibility assessments can improve infection management, thereby bringing patients’ relief. This study highlights the importance of early detection and suggests further studies on the prevalence and resistance patterns of filamentous bacteria in HIV-positive patients.

تازه های تحقیق

Omid Narimani (Google Scholar)
Golshid Javdani Shahedin (Google Scholar)
Ramin Mazaheri Nezhad Fard (Google Scholar)

کلیدواژه‌ها
Actinomycetes؛ Nocardia؛ Streptomyces؛ Oral cavity؛ HIV؛ Antibiotic resistance
مراجع
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