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Khan, Muhammad, Khan, Sanaullah, Khan, Muhammad, Rafiq, Khair, Yaqoob, Muhammad, Adnan, Muhammad. (1404). Immunogenetic Interplay of IL-6 and IL-6R Genes Variants and Circulating IL-6 Levels in ‎Toxoplasma gondii-infected Women with Recurrent Pregnancy Loss. سامانه مدیریت نشریات علمی, 23(1), 6-6. doi: 10.22034/iji.2026.108627.3107
Muhammad Bar Khan; Sanaullah Khan; Muhammad Fawad Khan; Khair Rafiq; Muhammad Yaqoob; Muhammad Adnan. "Immunogenetic Interplay of IL-6 and IL-6R Genes Variants and Circulating IL-6 Levels in ‎Toxoplasma gondii-infected Women with Recurrent Pregnancy Loss". سامانه مدیریت نشریات علمی, 23, 1, 1404, 6-6. doi: 10.22034/iji.2026.108627.3107
Khan, Muhammad, Khan, Sanaullah, Khan, Muhammad, Rafiq, Khair, Yaqoob, Muhammad, Adnan, Muhammad. (1404). 'Immunogenetic Interplay of IL-6 and IL-6R Genes Variants and Circulating IL-6 Levels in ‎Toxoplasma gondii-infected Women with Recurrent Pregnancy Loss', سامانه مدیریت نشریات علمی, 23(1), pp. 6-6. doi: 10.22034/iji.2026.108627.3107
Khan, Muhammad, Khan, Sanaullah, Khan, Muhammad, Rafiq, Khair, Yaqoob, Muhammad, Adnan, Muhammad. Immunogenetic Interplay of IL-6 and IL-6R Genes Variants and Circulating IL-6 Levels in ‎Toxoplasma gondii-infected Women with Recurrent Pregnancy Loss. سامانه مدیریت نشریات علمی, 1404; 23(1): 6-6. doi: 10.22034/iji.2026.108627.3107

Immunogenetic Interplay of IL-6 and IL-6R Genes Variants and Circulating IL-6 Levels in ‎Toxoplasma gondii-infected Women with Recurrent Pregnancy Loss

Iranian Journal of Immunology
دوره 23، شماره 1، خرداد 2026، صفحه 6-6
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2026.108627.3107
نویسندگان
Muhammad Bar Khan1؛ Sanaullah Khan* 1؛ Muhammad Fawad Khan2؛ Khair Rafiq1؛ Muhammad Yaqoob1؛ Muhammad Adnan1
1Institute of Zoological Sciences, University of Peshawar, Khyber Pakhtunkhwa, Pakistan.
2Department of Biotechnology and Life Sciences (DBSV), University of Insubria, Varese, Italy.
چکیده
Background: Recurrent pregnancy loss (RPL) is a global health challenge in women. It has been reported that Toxoplasma gondii (T. gondii) infection and interleukin-6 (IL-6) bioavailability contribute to RPL.
Objective: This study investigated IL-6 and IL-6 receptor (IL-6R) gene polymorphisms and blood IL-6 levels in T. gondii-infected women with RPL.
Methods: The study comprised 163 women, including 83 infected (Group A: subgroups A1, A2) and 80 healthy (Group B). Demographic data, blood, and placental tissue samples were collected. The blood samples were screened for IL-6 levels through ELISA. DNA was extracted, and T. gondii-DNA was identified using PCR. IL-6 and IL-6R genes were amplified by PCR and sequenced using the Sanger method.
Results: The IL-6 gene -174G/C (p=0.005) and -597G/A (p=0.0012) polymorphisms were significantly associated, while the -572G/C polymorphism was insignificantly associated (p=0.143) with infection and RPL. The mean blood IL-6 level was significantly variable across all groups (p < 0.001). The IL-6 gene -174GG and -597GG genotypes, and the IL-6R gene AA genotype, were common in Group-A2 (47.5%, 37.5%, 50%) and Group-B (56.2%, 60%, 68.8%), respectively, and were also significantly associated with elevated blood IL-6 levels. The -572GG genotype was common and was not significantly associated with elevated blood IL-6 levels across all groups (p=0.143). The IL-6 gene -174CC and -597AA genotypes and IL-6R gene CC genotype were highly prevalent in Group-A1 (48.8%, 41.9%, and 51.1%, respectively) and associated with low blood IL-6 levels.
Conclusion: The IL-6 gene -174G/C, -597G/A, and IL-6R gene A/C polymorphisms play significant roles in RPL in women infected with T. gondii, and change IL-6 bioavailability.
کلیدواژه‌ها
IL-6؛ IL-6R؛ RPL؛ SNP؛ T. gondii
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