LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,262
تعداد مقالات11,502
تعداد مشاهده مقاله81,854,819
تعداد دریافت فایل اصل مقاله120,988,222
Sattarian, Ali, Akbarzadeh Morshedi, Minoo. (1404). Key Phytochemicals with Anti-Aging Effects: A Narrative Review. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijns.2026.107333.1491
Ali Sattarian; Minoo Akbarzadeh Morshedi. "Key Phytochemicals with Anti-Aging Effects: A Narrative Review". سامانه مدیریت نشریات علمی, , , 1404, -. doi: 10.30476/ijns.2026.107333.1491
Sattarian, Ali, Akbarzadeh Morshedi, Minoo. (1404). 'Key Phytochemicals with Anti-Aging Effects: A Narrative Review', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijns.2026.107333.1491
Sattarian, Ali, Akbarzadeh Morshedi, Minoo. Key Phytochemicals with Anti-Aging Effects: A Narrative Review. سامانه مدیریت نشریات علمی, 1404; (): -. doi: 10.30476/ijns.2026.107333.1491

Key Phytochemicals with Anti-Aging Effects: A Narrative Review

International Journal of Nutrition Sciences
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 05 اسفند 1404    اصل مقاله (457.17 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijns.2026.107333.1491
نویسندگان
Ali Sattarian1؛ Minoo Akbarzadeh Morshedi* 2
1School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
2Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Science, Kashan University of Medical Sciences, Kashan, Iran
چکیده
Aging is a multifaceted biological process characterized by a decline in physiological function and increased susceptibility to age-related diseases. This narrative review explored the potential anti-aging effects of phytochemicals-bioactive compounds derived from plants by examining their mechanisms of action and health benefits. Phytochemicals exhibit significant antioxidant and anti-inflammatory properties that may mitigate oxidative stress and chronic inflammation, both of which are pivotal contributors to aging. We conducted a comprehensive search across major medical and scientific databases, including PubMed, Google Scholar, Web of Science, Scopus, and Embase, to identify reviews, meta-analyses, original articles, randomized clinical trials, and case series related to the anti-aging effects of phytochemicals. The search strategy utilized the keywords of phytochemicals, bioactive compounds, antioxidants, nutraceuticals, aging, oxidative stress, cellular senescence, and inflammation. Studies published between 2000 and 2025 were included, with an emphasis on the most recent and high-quality research addressing the role of phytochemicals in the aging process. Key phytochemicals such as resveratrol and curcumin can activate longevity-associated pathways, including sirtuins, to promote cellular health and longevity. Furthermore, phytochemicals can modulate cellular signaling pathways related to senescence and metabolic regulation. The integration of these compounds into dietary strategies presents a promising approach to enhance health. By elucidating the protective effects of phytochemicals against agerelated decline, this article aimed to inform future research directions and dietary recommendations for aging populations, ultimately contributing to improved health outcomes and quality of life in older adults.

تازه های تحقیق

Minoo Akbarzadeh Morshedi (Google Scholar)

کلیدواژه‌ها
Phytochemicals؛ Aging؛ Resveratrol؛ Curcumin؛ Quercetin
مراجع
  1. Kim JH, Yang D, Park S. Raman Spectroscopy in Cellular and Tissue Aging Research. Aging Cell. 2025;24:e14494. DOI: 10.1111/acel.14494. PMID: 39876576.
  2. Izquierdo M, de Souto Barreto P, Arai H, et al. Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR). J Nutr Health Aging. 2025;29:100401. DOI: 10.1016/j.jnha.2024.100401. PMID: 39743381.
  3. Costa CM, Pedrosa SS, Kirkland JL, et al. The senotherapeutic potential of phytochemicals for age-related intestinal disease. Ageing Res Rev. 2025;104:102619. DOI:10.1016/j.arr.2024.102619. PMID: 39638096.
  4. de Lima EP, Laurindo LF, Catharin VCS, et al. Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence. Metabolites. 2025;15:124. PMID: 39997749.
  5. Ismaila M, Adnan M, Sasidharan S. Exploring Medicinal Plants and Phytochemicals for Telomere Maintenance and Anti-aging: Insights into Telomerase Activation and Longevity. Revista Brasileira de Farmacognosia. 2025;35:275-290.
  6. Munteanu C, Galaction AI, Onose G, et al. Harnessing Gasotransmitters to Combat Age-Related Oxidative Stress in Smooth Muscle and Endothelial Cells. Pharmaceuticals (Basel). 2025;18:344. DOI:10.3390/ph18030344. PMID: 40143122.
  7. Hossain MS, Wazed MA, Asha S, et al. Dietary Phytochemicals in Health and Disease: Mechanisms, Clinical Evidence, and Applications—A Comprehensive Review. Food Sci Nutr. 2025;13:e70101. DOI: 10.1002/fsn3.70101. PMID: 40115248.
  8. Chaudhary S, Kaur P, Singh TA, et al. The dynamic crosslinking between gut microbiota and inflammation during aging: reviewing the nutritional and hormetic approaches against dysbiosis and inflammaging. Biogerontology. 2025;26:1. DOI: 10.1007/s10522-024-10146-2. PMID: 39441393.
  9. Segueni K, Chouikh A, Eddine Laouini S, et al. Evaluation of Dermal Wound Healing Potential: Phytochemical Characterization, Anti-Inflammatory, Antioxidant, and Antimicrobial Activities of Euphorbia guyoniana Boiss. & Reut. Latex. Chem Biodivers. 2025;22:e202402284. DOI:10.1002/cbdv.202402284. PMID: 39495036.
  10. Zheng Z, Gao J, Ma Y, et al. Cellular and Molecular Mechanisms of Phytochemicals Against Inflammation-Associated Diseases and Viral Infection. Cell Biol Int. 2025;49:606-33. DOI:10.1002/cbin.70011. PMID: 40091269.
  11. Ungurianu A, Margină D, Mihai DP, et al. Caloric restriction mimetics: Pinostilbene versus resveratrol regarding SIRT1 and SIRT6 interaction. Adv Med Sci. 2025;70:44-50. DOI: 10.1016/j.advms.2024.11.002. PMID: 39617052.
  12. AlHayani DA, Kubaev A, Uthirapathy S, et al. Insights Into the Therapeutic Potential of SIRT1-modifying Compounds for Alzheimer’s Disease: A Focus on Molecular Mechanisms. J Mol Neurosci. 2025;75:29. DOI: 10.1007/s12031-025-02324-9. PMID: 40000535.
  13. Beaver LM, Jamieson PE, Wong CP, et al. Promotion of healthy aging through the nexus of gut microbiota and dietary phytochemicals. Adv Nutr. 2025;16:100376. DOI: 10.1016/j.advnut.2025.100376. PMID: 39832641.
  14. Assalve G, Lunetti P, Rocca MS, et al. Exploring the Link Between Telomeres and Mitochondria: Mechanisms and Implications in Different Cell Types. Int J Mol Sci. 2025;26:993. DOI: 10.3390/ijms26030993. PMID: 39940762.
  15. Liu B, Peng Z, Zhang H, et al. Regulation of cellular senescence in tumor progression and therapeutic targeting: mechanisms and pathways. Mol Cancer. 2025;24:106. DOI:10.1186/s12943-025-02284-z. PMID: 40170077.
  16. Goyal K, Afzal M, Altamimi ASA, et al. Chronic kidney disease and aging: dissecting the p53/p21 pathway as a therapeutic target. Biogerontology. 2025;26:32. DOI: 10.1007/s10522-024-10173-z. PMID: 39725742.
  17. Balaraman AK, Afzal M, Moglad E, et al. The interplay of p16INK4a and non-coding RNAs: bridging cellular senescence, aging, and cancer. Biogerontology. 2025;26:50. DOI:10.1007/s10522-025-10194-2. PMID: 39907830.
  18. Yang A, Nouraie M, Pu J, et al. Distinct Senescence-associated Secretory Phenotype Mediators Associate With an Aging Endotype and Multiorgan Dysfunction in COPD. American J Respiratory Critical Care Med. 2025;211:A7689-A. DOI: 10.1164/ajrccm.2025.211.Abstracts.A7689.
  19. Malojirao VH, Vasquez V, Kodavati M, et al. Hemin-induced transient senescence via DNA damage response: a neuroprotective mechanism against ferroptosis in intracerebral hemorrhage. Commun Biol. 2025;8:622. DOI:10.1038/s42003-025-07983-3. PMID: 40247121.
  20. Park SS, Roh TH, Tanaka Y, et al. High p16INK4A expression in glioblastoma is associated with senescence phenotype and better prognosis. Neoplasia. 2025;60:101116. DOI: 10.1016/j.neo.2024.101116. PMID: 39724755.
  21. Constantinou SM, Bennett DC. Cell Senescence and the Genetics of Melanoma Development. Genes Chromosomes Cancer. 2024;63:e23273. DOI: 10.1002/gcc.23273. PMID: 39422311.
  22. Camacho-Encina M, Booth LK, Redgrave RE, et al. Cellular senescence, mitochondrial dysfunction, and their link to cardiovascular disease. Cells. 2024;13:353. DOI: 10.3390/cells13040353. PMID: 38391966.
  23. Lopes-Paciencia S, Ferbeyre G. Increased chromatin accessibility underpins senescence. FEBS J. 2025. DOI:10.1111/febs.70136. PMID: 40387486.
  24. Lai P, Liu L, Bancaro N, et al. Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway. Immunity. 2025;58:811-25.e7. DOI: 10.1016/j.immuni.2025.03.005. PMID: 40203808.
  25. García-Domínguez M. Pathological and Inflammatory Consequences of Aging. Biomolecules. 2025;15:404. DOI: 10.3390/biom15030404. PMID: 40149940.
  26. Kumar N, Walia HK. Cellular Senescence and Stem Cell Exhaustion: Implications for Aging and Regeneration. Cellular Senescence, Age-Related Disorders, and Emerging Treatments: Springer; 2025.p.103-33.
  27. McHugh D, Durán I, Gil J. Senescence as a therapeutic target in cancer and age-related diseases. Nat Rev Drug Discov. 2025;24:57-71. DOI: 10.1038/s41573-024-01074-4. PMID: 39548312.
  28. Tomas M, Gunal-Koroglu D, Kamiloglu S, et al. The state of the art in anti-aging: plant-based phytochemicals for skin care. Immun Ageing. 2025;22:5. DOI: 10.1186/s12979-025-00498-9. PMID: 39891253.
  29. Ugoeze KC, Odeku OA. Antioxidants in Infectious Disease Management. Antioxidants: Nature's Defense Against Disease. 2025:169-218. DOI: 10.1002/9781394270576.ch6.
  30. Prabu SM, Shagirtha K, Renugadevi J. Quercetin in combination with vitamins (C and E) improve oxidative stress and hepatic injury in cadmium intoxicated rats. Biomed Prevent Nutr. 2011;1:1-7. DOI: 10.1016/j.bionut.2010.12.003.
  31. Meng Q, Song C, Ma J, et al. Quercetin Prevents Hyperuricemia Associated With Gouty Arthritis by Inactivating the NLRP3/NF‐κB Signaling Pathway. Chem Biol Drug Des. 2025;105:e70103. DOI: 10.1111/cbdd.70103. PMID: 40230265.
  32. Lei JQ, Xie QL, Li QP, et al. Resveratrol Alleviates Liver Fibrosis by Targeting Cross‐Talk Between TLR2/MyD88/ERK and NF‐κB/NLRP3 Inflammasome Pathways in Macrophages. J Biochem Mol Toxicol. 2025;39:e70208. DOI: 10.1002/jbt.70208. PMID: 40079280.
  33. Hashemi SS, Rezaeian R, Rafati AR, et al. A review on application of herbals and their polymer composites in wound healing. Arab J Chem. 2024;17:1-15.
  34. Calcinotto A, Kohli J, Zagato E, et al. Cellular Senescence: Aging, Cancer, and Injury. Physiol Rev. 2019;99:1047-78. DOI:10.1152/physrev.00020.2018. PMID: 30648461.
  35. Zhu L, Yang M, Fan L, et al. Interaction between resveratrol and SIRT1: role in neurodegenerative diseases. Naunyn-Schmiedeberg's Arch Pharmacol. 2025;398:89-101. DOI: 10.1007/s00210-024-03319-w. PMID: 39105797.
  36. Ray A. Autophagy Fasting: Definition, Time Hour, Benefits, and Side effects. Compassionate AI. 2025;2:57-9.
  37. Ponce-Mora A, Salazar NA, Domenech-Bendaña A, et al. Interplay Between Polyphenols and Autophagy: Insights From an Aging Perspective. Front Biosci (Landmark Ed). 2025;30:25728. DOI: 10.31083/FBL25728. PMID: 40152368.
  38. Rezaei M, Hassanzadeh Nemati N, et al. Characterization of sodium carboxymethyl cellulose/calcium alginate scaffold loaded with curcumin in skin tissue engineering. J Appl Polymer Sci. 2022;139:52271. DOI: 10.1002/app.52271.
  39. Wu X, Al-Amin M, Zhao C, et al. Catechinic acid, a natural polyphenol compound, extends the lifespan of Caenorhabditis elegans via mitophagy pathways. Food Funct. 2020;11:5621-34. DOI: 10.1039/d0fo00694g. PMID: 32530444.
  40. Booth LN, Brunet A. The Aging Epigenome. Mol Cell. 2016;62:728-44. DOI: 10.1016/j.molcel.2016.05.013. PMID: 27259204.
  41. Mehrabani D, Khodakaram-Tafti A, Asadi-Yousefabad S, et al. Effect of age and passage on canine bone marrow derived mesenchymal stem cells. Onl J Vet Res. 2015;19:663-671.
  42. Dixit V, Chaubey KK, Dayal D, et al. Natural Products in Aging: Cellular Mechanisms and Emerging Therapeutics for Age‐Related Disorders. J Aging Res. 2025;2025:6868732.
  43. Bian Z, Li Z, Chang H, et al. Resveratrol Ameliorates Chronic Stress in Kennel Dogs and Mice by Regulating Gut Microbiome and Metabolome Related to Tryptophan Metabolism. Antioxidants (Basel). 2025;14:195. DOI:10.3390/antiox14020195. PMID: 40002382.
  44. Giovannelli L, Pitozzi V, Jacomelli M, et al. Protective effects of resveratrol against senescence-associated changes in cultured human fibroblasts. J Gerontol A Biol Sci Med Sci. 2011;66:9-18. DOI:10.1093/gerona/glq161. PMID: 20884849.
  45. Bhullar KS, Hubbard BP. Lifespan and healthspan extension by resveratrol. Biochim Biophys Acta. 2015;1852:1209-18. DOI:10.1016/j.bbadis.2015.01.012. PMID: 25640851.
  46. Alhazzani K, Alrewily SQ, Alanzi AR, et al. Therapeutic Effects of Liposomal Resveratrol in the Mitigation of Diabetic Nephropathy via Modulating Inflammatory Response, Oxidative Stress, and Apoptosis. Appl Biochem Biotechnol. 2025;197:1570-89. DOI:10.1007/s12010-024-05092-1. PMID: 39589702.
  47. Wang D, Liu J, Wang J, et al. Resveratrol protects against uremic serum-induced endothelial cell injury by activating the FUS/KLF2/FBXW7 signaling pathway. Appl Biol Chem. 2025;68:1-12.
  48. Zhao Q, Zhang Y, Liu J, et al. Polydatin enhances oxaliplatin-induced cell death by activating NOX5-ROS-mediated DNA damage and ER stress in colon cancer cells. Front Pharmacol. 2024;15:1532695. DOI:10.3389/fphar.2024.1532695. PMID: 39850563.
  49. Gutlapalli SD, Kondapaneni V, Toulassi IA, et al. The Effects of Resveratrol on Telomeres and Post Myocardial Infarction Remodeling. Cureus. 2020;12:e11482. DOI:10.7759/cureus.11482. PMID: 33329978.
  50. Koushki M, Dashatan NA, Meshkani R. Effect of Resveratrol Supplementation on Inflammatory Markers: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Clin Ther. 2018;40:1180-92 e5. DOI:10.1016/j.clinthera.2018.05.015. PMID: 30017172.
  51. Sahebkar A, Serban C, Ursoniu S, et al. Lack of efficacy of resveratrol on C-reactive protein and selected cardiovascular risk factors—Results from a systematic review and meta-analysis of randomized controlled trials. Int J Cardiol. 2015;189:47-55. DOI: 10.1016/j.ijcard.2015.04.008. PMID: 25885871.
  52. Tao G, Wang X, Wang J, et al. Dihydro-resveratrol ameliorates NLRP3 inflammasome-mediated neuroinflammation via Bnip3-dependent mitophagy in Alzheimer's disease. Br J Pharmacol. 2025;182:1005-24. DOI:10.1111/bph.17373. PMID: 39467709.
  53. Berman AY, Motechin RA, Wiesenfeld MY, et al. The therapeutic potential of resveratrol: a review of clinical trials. NPJ Precis Oncol. 2017;1:35. DOI: 10.1038/s41698-017-0038-6. PMID: 28989978.
  54. Carollo C, Sorce A, Cirafici E, et al. Sirtuins and Resveratrol in Cardiorenal Diseases: A Narrative Review of Mechanisms and Therapeutic Potential. Nutrients. 2025;17:1212. DOI:10.3390/nu17071212. PMID: 40218970.
  55. Wang XB, Zhu L, Huang J, et al. Resveratrol-induced augmentation of telomerase activity delays senescence of endothelial progenitor cells. Chin Med J (Engl). 2011;124:4310-5. PMID: 22340406.
  56. Gerić M, Nanić L, Micek V, Jovanović IN, Gajski G, Rašić D, et al. The Impact of Resveratrol and Melatonin on the Genome and Oxidative Status in Ageing Rats. Nutrients. 2025;17:1187. DOI: 10.3390/nu17071187. PMID: 40218945.
  57. Tu Kx, Ou Qj, Lin Ft, et al. Higher Intake of Resveratrol Is Associated With a Lower Risk of Colorectal Cancer: A Large‐Scale Case–Control Study. Phytother Res. 2025. DOI: 10.1002/ptr.8510. PMID: 40259782.
  58. Mehrabani D, Farjam M, Geramizadeh B, et al. The healing effect of curcumin on burn wounds in rat. World J Plast Surg. 2015;4:29-35. PMID: 25606474.
  59. Farjam M, Mehrabani D, Abbassnia F, et al. The healing effect of curcuma longa on liver in experimental acute hepatic encephalopathy of rat. Comp Clin Pathol. 2014;23:1669-1673.
  60. Rabbani-Haghighi N, Naghsh N, Mehrabani D. The protective effect of curcuma longa in thioacetamide-induced hepatic injury in rat. Global J Pharmacol. 2013;7:203-207. DOI: 10.5829/idosi.gjp.2013.7.2.74203
  61. Turer BY, Sanlier N. Relationship of curcumin with aging and Alzheimer and Parkinson disease, the most prevalent age-related neurodegenerative diseases: a narrative review. Nutr Rev. 2025;83:e1243-e58. DOI: 10.1093/nutrit/nuae079. PMID: 38916925.
  62. Bahrami A, Montecucco F, Carbone F, et al. Effects of Curcumin on Aging: Molecular Mechanisms and Experimental Evidence. Biomed Res Int. 2021;2021:8972074. DOI:10.1155/2021/8972074. PMID: 34692844.
  63. Panjehshahin Mr, Owji Aa, Mehrabani D, et al. Effect Of Curcumin On Cholesterol Gall-Stone Induction In Rats. J Appl Anim Res. 2003;23:75-80.
  64. Lee YM, Kim Y. Is Curcumin Intake Really Effective for Chronic Inflammatory Metabolic Disease? A Review of Meta-Analyses of Randomized Controlled Trials. Nutrients. 2024;16:1728. DOI: 10.3390/nu16111728. PMID: 38892660.
  65. Lestari CR, Dewi RAEP, Nurjanah S, et al. The Effect of Green Coffee Seed (Coffea Canephora) and Yellow Turmeric (Curcuma Domestica Val.) Extract on TNF-α Level in Acute Respiratory Distress Syndrome. Int J Nutr Sci. 2022;7:210-216. DOI: 10.30476/ijns.2022.97406.1209.
  66. Bielak-Zmijewska A, Grabowska W, Ciolko A, et al. The Role of Curcumin in the Modulation of Ageing. Int J Mol Sci. 2019;20:1239. DOI:10.3390/ijms20051239. PMID: 30871021.
  67. Izadi M, Sadri N, Abdi A, et al. Longevity and anti-aging effects of curcumin supplementation. Geroscience. 2024;46:2933-50. DOI:10.1007/s11357-024-01092-5. PMID: 38409646.
  68. Liu X, Lin L, Hu G. Meta-analysis of the effect of curcumin supplementation on skeletal muscle damage status. PLoS One. 2024;19:e0299135. DOI:10.1371/journal.pone.0299135. PMID: 39008500.
  69. Nunes YC, Mendes NM, Pereira de Lima E, et al. Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence. Nutrients. 2024;16:2721. DOI:10.3390/nu16162721. PMID: 39203857.
  70. Voulgaropoulou SD, Van Amelsvoort T, Prickaerts J, Vingerhoets C. The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies. Brain Res. 2019;1725:146476. DOI: 10.1016/j.brainres.2019.146476. PMID: 31560864.
  71. Malekzadeh S, Edalatmanesh MA, Mehrabani D, et al. Drugs induced Alzheimer's disease in animal model. Galen Med J. 2017;6:185-96. DOI: 10.31661/gmj.v6i3.820.
  72. Nunes YC, Mendes NM, Pereira de Lima E, et al. Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence. Nutrients. 2024;16:2721. DOI:10.3390/nu16162721. PMID: 39203857.
  73. Mankowski RT, Sibille KT, Leeuwenburgh C, et al. Effects of Curcumin C3 Complex(R) on Physical Function in Moderately Functioning Older Adults with Low-Grade Inflammation - A Pilot Trial. J Frailty Aging. 2023;12:143-9. DOI:10.14283/jfa.2022.47. PMID: 36946712.
  74. Chang YH. Curcumin as a potential therapeutic agent for Parkinson’s disease: a systematic review. Front Pharmacol. 2025;16:1593191. DOI: 10.3389/fphar.2025.1593191. PMID: 40331193.
  75. Chahardehi AM, Arefnezhad R, Pourbafrani A, et al. MicroRNAs modulation by curcumin, catalpol, and other natural products in Alzheimer’s disease: a review. Mol Biol Rep. 2025;52:1-18. DOI: 10.1007/s11033-025-10543-x. PMID: 40327129.
  76. Lee YM, Kim Y. Is Curcumin Intake Really Effective for Chronic Inflammatory Metabolic Disease? A Review of Meta-Analyses of Randomized Controlled Trials. Nutrients. 2024;16:1728. DOI:10.3390/nu16111728. PMID: 38892660.
  77. Saraf-Bank S, Ahmadi A, Paknahad Z, et al. Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: A randomized placebo-controlled clinical trial. Phytother Res. 2019;33:2015-22. DOI:10.1002/ptr.6370. PMID: 31206225.
  78. Baghcheghi Y, Razazpour F, Mirzaee F, et al. Exploring the molecular mechanisms of curcumin in modulating memory impairment in neurodegenerative disorders. Mol Biol Rep. 2025;52:45. DOI: 10.1007/s11033-024-10115-5. PMID: 39653966.
  79. Yousef-Nezhad H, Hejazi N. Anti-Bacterial Properties of Herbs against Helicobacter Pylori
Infection: A Review. Int J Nutr Sci. 2017;2:126-133.

  1. Che K, Wang C, Chen H. Advancing functional foods: A systematic analysis of plant-derived exosome-like nanoparticles and their health-promoting properties. Front Nutr. 2025;12:1544746. DOI: 10.3389/fnut.2025.1544746. PMID: 40115388.
  2. Imb M, Veghelyi Z, Maurer M, et al. Exploring Senolytic and Senomorphic Properties of Medicinal Plants for Anti-Aging Therapies. Int J Mol Sci. 2024;25:10419. DOI:10.3390/ijms251910419. PMID: 39408750.
  3. Khodabandeh Z, Dolati P, Zamiri MJ, et al. Protective Effect of Quercetin on Testis Structure and Apoptosis Against Lead Acetate Toxicity: an Stereological Study. Biol Trace Elem Res. 2021;199:3371-3381. DOI: 10.1007/s12011-020-02454-8. PMID: 33107017.
  4. Dolati P, Zamiri MJ, Akhlaghi A, et al. Reproductive and embryological toxicity of lead acetate in male mice and their offspring and mitigation effects of quercetin. J Trace Elem Med Biol. 2021;67:126793. DOI: 10.1016/j.jtemb.2021.126793. PMID: 34049200.
  5. Zhang M, Zhang G, Meng X, et al. Reduction of the oxidative damage to H2O2-induced HepG2 cells via the Nrf2 signalling pathway by plant flavonoids Quercetin and Hyperoside. Food Science and Human Wellness. 2024;13:1864-76. DOI: 10.26599/FSHW.2022.9250155.
  6. Alharbi HOA, Alshebremi M, Babiker AY, et al. The Role of Quercetin, a Flavonoid in the Management of Pathogenesis Through Regulation of Oxidative Stress, Inflammation, and Biological Activities. Biomolecules. 2025;15:151. DOI: 10.3390/biom15010151. PMID: 39858545.
  7. Shah MA, Faheem HI, Hamid A, et al. The entrancing role of dietary polyphenols against the most frequent aging‐associated diseases. Med Res Rev. 2024;44:235-74. DOI: 10.1002/med.21985. PMID: 37486109.
  8. Garzón‐García L, Ayuda‐Durán B, González‐Manzano S, et al. Neuroprotective Potential of the Flavonoids Quercetin and Epicatechin in a C. elegans Tauopathy Model. Mol Nutr Food Res. 2025:e70108. DOI: 10.1002/mnfr.70108. PMID: 40351085.
  9. Dos Santos MG, Arbo BD, Hort MA. Effects of quercetin and its derivatives in in vivo models of neuroinflammation: a systematic review and meta-analysis. Neural Regen Res. 2026;21:1783-1792. DOI:10.4103/NRR.NRR-D-24-01175. PMID: 40145967.
  10. Nishikawa T, Takeda R, Ueda S, et al. Quercetin ingestion alters motor unit behavior and enhances improvement in muscle strength following resistance training in older adults: a randomized, double-blind, controlled trial. Eur J Nutr. 2025;64:117. DOI:10.1007/s00394-025-03634-9. PMID: 40063125.
  11. Bientinesi E, Ristori S, Lulli M, et al. Quercetin induces senolysis of doxorubicin-induced senescent fibroblasts by reducing autophagy, preventing their pro-tumour effect on osteosarcoma cells. Mech Ageing Dev. 2024;220:111957. DOI: 10.1016/j.mad.2024.111957. PMID: 38909661.
  12. Okselni T, Septama AW, Juliadmi D, et al. Quercetin as a therapeutic agent for skin problems: a systematic review and meta-analysis on antioxidant effects, oxidative stress, inflammation, wound healing, hyperpigmentation, aging, and skin cancer. Naunyn Schmiedebergs Arch Pharmacol. 2025;398:5011-55. DOI: 10.1007/s00210-024-03722-3. PMID: 39738831.
  13. Capasso L, De Masi L, Sirignano C, et al. Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential. Molecules. 2025;30:654. DOI:10.3390/molecules30030654. PMID: 39942757.
  14. Yuan M, Hu L, Zhu C, et al. Comparison and Assessment of Anti‐Inflammatory and Antioxidant Capacity Between EGCG and Phosphatidylcholine‐Encapsulated EGCG. J Cosmet Dermatol. 2025;24:e16628. DOI: 10.1111/jocd.16628. PMID: 39482802.
  15. Zhang B, Zeng M, Tie Q, et al. (-)-Epigallocatechin-3-gallate (EGCG) ameliorates ovalbumin-induced asthma by inhibiting inflammation via the TNF-alpha/TNF-R1/NLRP3 signaling pathway. Int Immunopharmacol. 2025;144:113708. DOI:10.1016/j.intimp.2024.113708. PMID: 39626539.
  16. Al-Regaiey K. Crosstalk between adipogenesis and aging: role of polyphenols in combating adipogenic-associated aging. Immun Ageing. 2024;21:76. DOI: 10.1186/s12979-024-00481-w. PMID: 39511615.
  17. Chen X, Walton K, Brodaty H, et al. Polyphenols and diets as current and potential nutrition senotherapeutics in Alzheimer’s disease: findings from clinical trials. J Alzheimers Dis. 2024;101:S479-S501. DOI: 10.3233/JAD-231222. PMID: 38875032.
  18. Li H, Zheng C, Wang Z, et al. Neuroprotective Effects of Catechins by Differentially Affecting the Binding of Beta-amyloid and Its Aggregates to the Target Cells. Mol Neurobiol. 2025;62:9861-9880. DOI:10.1007/s12035-025-04870-0. PMID: 40172817.
  19. Fitzgerald KN, Hodges R, Hanes D, et al. Correction: Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial. Aging (Albany NY). 2024;16:4943-5. DOI:10.18632/aging.205700. PMID: 38488762.
  20. Delabar JM, Gomes M, Fructuoso M, et al. EGCG-like non-competitive inhibitor of DYRK1A rescues cognitive defect in a down syndrome model. Eur J Med Chem. 2024;265:116098. DOI:10.1016/j.ejmech.2023.116098. PMID: 38171148.
  21. Cieuta-Walti C, Cuenca-Royo A, Langohr K, et al. Safety and preliminary efficacy on cognitive performance and adaptive functionality of epigallocatechin gallate (EGCG) in children with Down syndrome. A randomized phase Ib clinical trial (PERSEUS study). Genet Med. 2022;24:2004-13. DOI:10.1016/j.gim.2022.06.011. PMID: 35951014.
  22. Mereles D, Hunstein W. Epigallocatechin-3-gallate (EGCG) for clinical trials: more pitfalls than promises? Int J Mol Sci. 2011;12:5592-603. DOI: 10.3390/ijms12095592. PMID: 22016611.
  23. Tan J, Vincken JP, van Zadelhoff A, et al. Presence of free gallic acid and gallate moieties reduces auto-oxidative browning of epicatechin (EC) and epicatechin gallate (ECg). Food Chem. 2023;425:136446. DOI: 10.1016/j.foodchem.2023.136446. PMID: 37245463.
  24. Godoy MCXd, Monteiro GA, Moraes BHd, Macedo JA, Gonçalves GMS, Gambero A. Addition of polyphenols to drugs: the potential of controlling “inflammaging” and fibrosis in human senescent lung fibroblasts in vitro. Int J Mol Sci. 2024;25:7163. DOI: 10.3390/ijms25137163. PMID: 39000270.
  25. Peng H, Shahidi F. Oxidation and degradation of (epi)gallocatechin gallate (EGCG/GCG) and (epi)catechin gallate (ECG/CG) in alkali solution. Food Chem. 2023;408:134815. DOI:10.1016/j.foodchem.2022.134815. PMID: 36549155.
  26. Sharma R, Diwan B. An update on healthspan and lifespan enhancing attributes of tea amidst the emerging understanding of aging biology. Human Nutr Metab. 2022;28:200149. DOI: 10.1016/j.hnm.2022.200149.
  27. Li Z, Feng C, Dong H, et al. Health promoting activities and corresponding mechanism of (–)-epicatechin-3-gallate. Food Sci Human Wellness. 2022;11:568-78. DOI:10.1016/j.fshw.2021.12.013
  28. Seo H, Lee SH, Park Y, et al. (-)-Epicatechin-Enriched Extract from Camellia sinensis Improves Regulation of Muscle Mass and Function: Results from a Randomized Controlled Trial. Antioxidants (Basel). 2021;10:1026. DOI:10.3390/antiox10071026. PMID: 34202133.
  29. de la Torre R, de Sola S, Hernandez G, et al. Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial. Lancet Neurol. 2016;15:801-10. DOI:10.1016/S1474-4422(16)30034-5. PMID: 27302362.
  30. Qin K, Liang W, Fragoulis A, et al. Sulforaphane regulates hepatic autophagy and apoptosis by modulating Kupffer cells’ polarization via Nrf2/HO-1 pathway in the murine hemorrhagic shock/resuscitation model. Eur J Trauma Emerg Surg. 2025;51:218. DOI: 10.1007/s00068-025-02890-y. PMID: 40407885.
  31. Fahey JW, Liu H, Batt H, et al. Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders. Nutrients. 2025;17:1353. DOI:10.3390/nu17081353. PMID: 40284217.
  32. Yang L, Wu W, Yang J, et al. Nanoparticle-mediated delivery of herbal-derived natural products to modulate immunosenescence-induced drug resistance in cancer therapy: a comprehensive review. Front Oncol. 2025;15:1567896. DOI: 10.3389/fonc.2025.1567896. PMID: 40356750.
  33. Yang W, Zeng S, Shao R, et al. Sulforaphane regulation autophagy-mediated pyroptosis in autoimmune hepatitis via AMPK/mTOR pathway. Int Immunopharmacol. 2025;146:113826. DOI: 10.1016/j.intimp.2024.113826. PMID: 39673998.
  34. Axelsson AS, Tubbs E, Mecham B, et al. Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes. Sci Transl Med. 2017;9:eaah4477. DOI:10.1126/scitranslmed.aah4477. PMID: 28615356.
  35. Tobón-Cornejo S, Vargas-Castillo A, Juarez M, et al. Metabolic reprogramming and synergistic cytotoxicity of genistein and chemotherapy in human breast cancer cells. Life Sci. 2025;370:123562. DOI: 10.1016/j.lfs.2025.123562. PMID: 40090516.
  36. Sharifi-Rad J, Quispe C, Imran M, et al. Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits. Oxid Med Cell Longev. 2021;2021:3268136. DOI:10.1155/2021/3268136. PMID: 34336089.
  37. Liu X, Zheng T, Bao Y, et al. Genistein Implications in Radiotherapy: Kill Two Birds with One Stone. Molecules. 2025;30:188. DOI:10.3390/molecules30010188. PMID: 39795243.
  38. Domaszewska-Szostek A, Puzianowska-Kuznicka M, Kurylowicz A. Flavonoids in Skin Senescence Prevention and Treatment. Int J Mol Sci. 2021;22:6814. DOI:10.3390/ijms22136814. PMID: 34201952.
  39. Mannino F, D'Angelo T, Pallio G, et al. The Nutraceutical Genistein-Lycopene Combination Improves Bone Damage Induced by Glucocorticoids by Stimulating the Osteoblast Formation Process. Nutrients. 2022;14:4296. DOI:10.3390/nu14204296. PMID: 36296984.
  40. Marini H, Minutoli L, Polito F, et al. Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial. Ann Intern Med. 2007;146:839-47. DOI:10.7326/0003-4819-146-12-200706190-00005.
  41. Morabito N, Crisafulli A, Vergara C, et al. Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study. J Bone Miner Res. 2002;17:1904-12. DOI:10.1359/jbmr.2002.17.10.1904.
  42. Arcoraci V, Atteritano M, Squadrito F, et al. Antiosteoporotic Activity of Genistein Aglycone in Postmenopausal Women: Evidence from a Post-Hoc Analysis of a Multicenter Randomized Controlled Trial. Nutrients. 2017;9:179. DOI:10.3390/nu9020179. PMID: 28241420.
آمار
تعداد مشاهده مقاله: 10
تعداد دریافت فایل اصل مقاله: 5


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب