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Investigating Diagnostic and Prognostic Biomarkers in Gingival Crevicular Fluid across Systemic Conditions | ||
| Journal of Dentistry | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 03 اسفند 1404 اصل مقاله (628.65 K) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.30476/dentjods.2026.106219.2679 | ||
| نویسندگان | ||
| Mohammad Amin Amiri* 1؛ Mohammad Norouzi2؛ Shahram Hamedani1؛ Nima Fartshidfar3 | ||
| 1Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 2Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 3Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| چکیده | ||
| Gingival crevicular fluid (GCF), as a biofluid originating from gingival crevice transudate holds promising potential as a diagnostic tool for systemic diseases. Clinical investigations have revealed the substantial impact of different systemic conditions on the dynamic levels of various biomarkers present in GCF, encompassing a diverse array of molecules and agents. Based on existing evidence, this narrative review critically examines the effects of various systemic diseases on GCF composition, shedding light on the evolving landscape of GCF as a source of specific biomarkers. A systematic search was conducted in two databases (PubMed, and Scopus) using Mesh terms and proper Boolean operators until May 26, 2025. The original research articles, written in English, and focusing on human studies were screened for further assessment. A selected number of studies were included to assess the current research trends and findings in the field. Drawing from observational studies, we unveiled the various types of GCF biomarkers associated with the most commonly studied systemic diseases, including metabolic syndrome, liver diseases, rheumatoid arthritis, diabetes mellitus, cardiovascular diseases, and acquired immunodeficiency syndrome. The connection of each disease with GCF was separately discussed. Besides, the potential applicability of the assessed biomarkers in each disease is also elaborated upon for future implications. GCF has shown a potential opportunity in terms of diagnostic and prognostic evaluation of systemic diseases. By elucidating the intricate relationship between systemic health and periodontal status, this review has emphasized the untapped potential of GCF as a diagnostic means for systemic diseases, prognostication of their progression, and evaluation of therapy responses, a crucial step toward advancing personalized medicine. | ||
| کلیدواژهها | ||
| Gingival Crevicular Fluid؛ Gingival Exudate؛ Biomarkers؛ Diagnosis؛ Periodontal Diseases؛ Systemic Diseases | ||
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آمار تعداد مشاهده مقاله: 6 تعداد دریافت فایل اصل مقاله: 3 |
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