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Paymani, Zeinab, Nazari, Mostafa, Mirnia, Kayvan, Sangsari, Razieh, Ebrahimi, Marzieh, Haghighi, Fatemeh. (1404). Rethinking Neonatal Vaccination Policies: A Neuroimmune Perspective. سامانه مدیریت نشریات علمی, 51(2), 84-103. doi: 10.30476/ijms.2025.106591.4083
Zeinab Paymani; Mostafa Nazari; Kayvan Mirnia; Razieh Sangsari; Marzieh Ebrahimi; Fatemeh Haghighi. "Rethinking Neonatal Vaccination Policies: A Neuroimmune Perspective". سامانه مدیریت نشریات علمی, 51, 2, 1404, 84-103. doi: 10.30476/ijms.2025.106591.4083
Paymani, Zeinab, Nazari, Mostafa, Mirnia, Kayvan, Sangsari, Razieh, Ebrahimi, Marzieh, Haghighi, Fatemeh. (1404). 'Rethinking Neonatal Vaccination Policies: A Neuroimmune Perspective', سامانه مدیریت نشریات علمی, 51(2), pp. 84-103. doi: 10.30476/ijms.2025.106591.4083
Paymani, Zeinab, Nazari, Mostafa, Mirnia, Kayvan, Sangsari, Razieh, Ebrahimi, Marzieh, Haghighi, Fatemeh. Rethinking Neonatal Vaccination Policies: A Neuroimmune Perspective. سامانه مدیریت نشریات علمی, 1404; 51(2): 84-103. doi: 10.30476/ijms.2025.106591.4083

Rethinking Neonatal Vaccination Policies: A Neuroimmune Perspective

Iranian Journal of Medical Sciences
مقاله 2، دوره 51، شماره 2، اردیبهشت 2026، صفحه 84-103    اصل مقاله (1.11 M)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijms.2025.106591.4083
نویسندگان
Zeinab Paymani1؛ Mostafa Nazari* 1؛ Kayvan Mirnia2؛ Razieh Sangsari2؛ Marzieh Ebrahimi3؛ Fatemeh Haghighi1
1Department of Nuclear Medicine, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
2Department of Neonatology, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
3Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
چکیده
Neonatal vaccination is a cornerstone of early-life infectious disease prevention. However, the timing and safety of these interventions require careful consideration. This review explored the neuroimmune implications of early immunization, with a specific focus on the interplay between the developing immune and nervous systems. We examined potential mechanisms through which vaccine-induced immune activation might influence brain development, through epigenetic modifications and sustained cytokine responses, particularly involving interleukin-6 (IL-6). The discussion addressed concerns related to immune overstimulation, regulatory T-cell suppression, and microbiome disruption, considering their potential links to autoimmune and neurodevelopmental disorders. In light of the identified evidence gaps, we advocate for a cautious, individualized vaccination approach guided by the “As Low and Late As Reasonably Achievable” (ALLARA) principle. This strategy aimed to balance robust protection against infectious diseases with the imperative of safeguarding lifelong neurological and immunological health.

تازه های تحقیق

Zeinab Paymani (Google Scholar)
Mostafa Nazari (Google Scholar)

کلیدواژه‌ها
Vaccine؛ Epigenetics؛ Autoimmune diseases؛ Nervous system diseases؛ Birth dose vaccine
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