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Gholipour, Farshad, Gharakhani, Davoud, Rahavian, Amirhossein, Norouzi, Mahdi, Hajian, Mohammadreza, Vahidi, Serajoddin, Nazarpour, Mohammad Javad, Khorrami, Farbod. (1404). Probiotics Outperform Antioxidants in Improving Semen Parameters of Men with Idiopathic Oligoasthenoteratozoospermia: A Randomized Controlled Trial. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijms.2025.105150.3888
Farshad Gholipour; Davoud Gharakhani; Amirhossein Rahavian; Mahdi Norouzi; Mohammadreza Hajian; Serajoddin Vahidi; Mohammad Javad Nazarpour; Farbod Khorrami. "Probiotics Outperform Antioxidants in Improving Semen Parameters of Men with Idiopathic Oligoasthenoteratozoospermia: A Randomized Controlled Trial". سامانه مدیریت نشریات علمی, , , 1404, -. doi: 10.30476/ijms.2025.105150.3888
Gholipour, Farshad, Gharakhani, Davoud, Rahavian, Amirhossein, Norouzi, Mahdi, Hajian, Mohammadreza, Vahidi, Serajoddin, Nazarpour, Mohammad Javad, Khorrami, Farbod. (1404). 'Probiotics Outperform Antioxidants in Improving Semen Parameters of Men with Idiopathic Oligoasthenoteratozoospermia: A Randomized Controlled Trial', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijms.2025.105150.3888
Gholipour, Farshad, Gharakhani, Davoud, Rahavian, Amirhossein, Norouzi, Mahdi, Hajian, Mohammadreza, Vahidi, Serajoddin, Nazarpour, Mohammad Javad, Khorrami, Farbod. Probiotics Outperform Antioxidants in Improving Semen Parameters of Men with Idiopathic Oligoasthenoteratozoospermia: A Randomized Controlled Trial. سامانه مدیریت نشریات علمی, 1404; (): -. doi: 10.30476/ijms.2025.105150.3888

Probiotics Outperform Antioxidants in Improving Semen Parameters of Men with Idiopathic Oligoasthenoteratozoospermia: A Randomized Controlled Trial

Iranian Journal of Medical Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 09 دی 1404    اصل مقاله (1.22 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2025.105150.3888
نویسندگان
Farshad Gholipour1؛ Davoud Gharakhani2؛ Amirhossein Rahavian* 3؛ Mahdi Norouzi4؛ Mohammadreza Hajian5؛ Serajoddin Vahidi2؛ Mohammad Javad Nazarpour1؛ Farbod Khorrami6
1Isfahan Kidney Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2Department of Surgery, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
3Andrology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
5Nikan Research Institute, Isfahan, Iran
6Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
چکیده
Background: Idiopathic oligoasthenoteratozoospermia (iOAT) treatment still poses significant challenges. This study aims to compare the therapeutic efficacy of probiotics on sperm parameters of iOAT patients with placebo and antioxidants.
Methods: In this triple-blind, randomized controlled trial, 110 men with iOAT were assigned to receive either a probiotic (Familact®), an antioxidant (Sperigen®), or a placebo daily for 3 months, in two academic centers in Iran (Isfahan and Yazd). The study was conducted from July 2021 to April 2022. Sperm parameters were analyzed using computer-assisted semen analysis. The main measured outcomes included semen volume and sperm features, including motility, morphology, and concentration. Changes in semen parameters were assessed using linear mixed-effects models with fixed effects for time, group, and their interaction. Estimated marginal means were compared across groups using Bonferroni-adjusted pairwise tests.
Results: Overall, 110 men (mean age of 34.3±4.5 years) were included in the final analysis. Significant Time×Group interactions were found for sperm concentration (P=0.003), motility (P<0.001), and morphology (P<0.001), but not for semen volume (P=0.71). After 3 months, the probiotic group showed significantly greater improvements in sperm concentration (10.42±1.11×106/mL, P=0.007), motility (46.65±3.73%, P=0.001), and morphology (4.31±0.21%, P<0.001) compared to the placebo group. Additionally, probiotics outperformed antioxidants in morphology (P<0.001) and motility (P=0.009).  
Conclusion: This study is the first to directly compare probiotics and antioxidants in treating iOAT. Probiotics showed superior performance in sperm motility and morphology compared to antioxidants, although drawing a strong conclusion requires further robust studies.
Trial Registration Number: IRCT20150420021869N5.

تازه های تحقیق

Farshad Gholipour (Google Scholar)
Amirhossein Rahavian (Google Scholar)

کلیدواژه‌ها
Probiotics؛ Antioxidants؛ Oligospermia؛ Male infertility؛ Andrology
مراجع
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