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Malva Sylvestris Mucoadhesive Tablets in the Management of Recurrent Aphthous Stomatitis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial | ||
| Journal of Dentistry | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 08 دی 1404 اصل مقاله (430.92 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/dentjods.2025.107535.2752 | ||
| نویسندگان | ||
| Maede Salehi1؛ Somayeh Shahani2؛ Majid Saeedi3؛ Reza Negarandeh4؛ Abolfazl Hosseinnataj5؛ Iman Misagh6؛ Ali Jafari7؛ Anahita Lotfizadeh7؛ Tahereh Molania* 1 | ||
| 1Dept. of Oral Medicine, Dental Research Center, Mazandaran University of Medical Sciences, Sari, Iran. Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran. | ||
| 2Medicinal Plants Research Center, Dept. of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. | ||
| 3Dept. of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. | ||
| 4Pharmaceutical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. | ||
| 5Dept. of Biostatistics, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran. | ||
| 6Oral and Maxillofacial Resident, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| 7Dentist, Sari, Iran. | ||
| چکیده | ||
| Background: Recurrent aphthous stomatitis (RAS) is an oral inflammatory lesion with unspecified etiology and no definite treatment. Mallow is an herbal medicine with anti-oxidant and anti-inflammatory properties. Purpose: Considering the effectiveness of mallow (Malva sylvestris L.) in managing wounds and inflammation, this research was conducted to discover the efficacy of mallow mucoadhesive tablets on aphthous lesions. Materials and Method: This randomized, double-blind clinical trial was conducted evaluating 42 patients. The participants were randomly allocated into two groups including the intervention (mallow) and the control (placebo) groups. The patients took tablets three times a day. The lesions’ diameter was measured with caliper on days zero (base-line), three, five, and seven. The pain intensity was evaluated by the visual analogue scale. To examine homogeneity of the two groups, chi-square test and the independent t-test were used for qualitative and quantitative variables, respectively. Independent t-test and Mann-Whitney’s non-parametric t-test were used to analyze pain intensity and lesion diameter, respectively. A significance level of 5% was considered. Data were analyzed by SPSS23. Results: The mean lesion diameter on the third day did not show a significant difference between the two groups (p Value> 0.05), but on the base-line, fifth, and seventh days, the difference between the two groups was significant, and the size of lesions of the intervention group decreased in shorter healing time (p< 0.05). Pain intensity had a significant decrease over time (p< 0.05), and pain intensity in the intervention group was significantly lower than in the control group (p< 0.05). Conclusion: It seems that mallow mucoadhesive tablets effectively reduce pain intensity and boost the healing process in patients with RAS. | ||
| کلیدواژهها | ||
| Aphthous Stomatitis؛ Herbal Medicine؛ Malva sylvestris L؛ Oral Medicine؛ Pain | ||
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آمار تعداد مشاهده مقاله: 4 تعداد دریافت فایل اصل مقاله: 3 |
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