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Tejaswi siddappa, Poornachandra, Sunkappa, Shamsundar, Desai, Vinay, Kunigal Puttaswamy, Jagannath, Ramanand, Nanda, Katke, Aradhana, Boraiah, Thejaswini. (1405). Evaluation of testis as organ at risk in carcinoma rectum with various radiotherapy delivery techniques. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/mejc.2025.104779.2207
Poornachandra Tejaswi siddappa; Shamsundar Sunkappa; Vinay Desai; Jagannath Kunigal Puttaswamy; Nanda Ramanand; Aradhana Katke; Thejaswini Boraiah. "Evaluation of testis as organ at risk in carcinoma rectum with various radiotherapy delivery techniques". سامانه مدیریت نشریات علمی, , , 1405, -. doi: 10.30476/mejc.2025.104779.2207
Tejaswi siddappa, Poornachandra, Sunkappa, Shamsundar, Desai, Vinay, Kunigal Puttaswamy, Jagannath, Ramanand, Nanda, Katke, Aradhana, Boraiah, Thejaswini. (1405). 'Evaluation of testis as organ at risk in carcinoma rectum with various radiotherapy delivery techniques', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/mejc.2025.104779.2207
Tejaswi siddappa, Poornachandra, Sunkappa, Shamsundar, Desai, Vinay, Kunigal Puttaswamy, Jagannath, Ramanand, Nanda, Katke, Aradhana, Boraiah, Thejaswini. Evaluation of testis as organ at risk in carcinoma rectum with various radiotherapy delivery techniques. سامانه مدیریت نشریات علمی, 1405; (): -. doi: 10.30476/mejc.2025.104779.2207

Evaluation of testis as organ at risk in carcinoma rectum with various radiotherapy delivery techniques

Middle East Journal of Cancer
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 12 فروردین 1405    اصل مقاله (330.87 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2025.104779.2207
نویسندگان
Poornachandra Tejaswi siddappa* 1؛ Shamsundar Sunkappa2؛ Vinay Desai3؛ Jagannath Kunigal Puttaswamy2؛ Nanda Ramanand2؛ Aradhana Katke2؛ Thejaswini Boraiah2
1Department of Radiation Oncology, Karnataka cancer therapy and research institute, Navanagar, Hubli-580025.
2Department of Radiation Oncology, Kidwai memorial institute of oncology, Hombegowda Nagar, Bengaluru, Karnataka, India-560029.
3Department of Medical Physics, Kidwai memorial institute of oncology, Hombegowda Nagar, Bengaluru, Karnataka, India-560029.
چکیده
Background: Due to the close approximation of testis to radiotherapy treatment field in male carcinoma rectum patients, it receives either scattered or direct radiation. The present study aimed to investigate the impact of considering testis as organ at risk with different radiotherapy techniques.
Material and methods: This mono-centric, multi-arm, prospective, observational study was conducted with 160 male rectal cancer patients between 2019 to 2024, aged >18years treated with neo-adjuvant radiotherapy followed by total mesorectal resection. We designed two-dimensional, three-dimensional, intensity modulated and volumetric modulated arc radiotherapy, with 40 patients in each technique. Tumor stage, length and thickness, testicular dose and volume, planned target volume and its distance from anal verge in each technique was considered, along with the assessment of testis as organ at risk. SPSS-22.0, R environment-3.2.2 and Microsoft excel were used for data analysis. The two-tailed t-test and Analysis of variance (ANOVA) were performed to assess the level of significance with P<0.05.
Results: The mean dose to right and left testis (in centi-gray) with two-dimensional radiotherapy was 925.79 and 776.70, while the dose contribution to testis when considered as organ at risk resulted in 336.23 and 206.65 with three-dimensional radiotherapy, 165.15 and 140.25 in intensity modulated radiotherapy and 209.2 and 229.2 in volumetric modulated arc therapy. Planned target volume, testis as organ at risk and treatment technique showed statistical significance with testicular dose received.
Conclusions: Considering testis as organ at risk contributed to significant dose reduction in conformal technique, with better sparing observed in intensity modulated radiotherapy whereas testicular shielding is needed in two-dimensional radiotherapy.
کلیدواژه‌ها
Testis؛ Organs at Risk؛ Neoadjuvant Therapy؛ Radiotherapy؛ Rectal Neoplasms
مراجع
  1. Duzova M, Basaran H, Inan G, Gul OV, Eren OO, Korez MK. Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: Outcomes of survival, toxicity, sphincter preserving and prognostic factors. TransplImmunol. 2021 Dec;69:101489. doi: 10.1016/j.trim.2021.101489. Epub 2021 Oct 20. PMID: 34687908.
  2. Wiltink LM, Chen TY, Nout RA, Kranenbarg EM, Fiocco M, Laurberg S, van de Velde CJ, Marijnen CA. Health-related quality of life 14 years after preoperative short-term radiotherapy and total mesorectal excision for rectal cancer: report of a multicenter randomised trial. Eur J Cancer. 2014 Sep;50(14):2390-8. doi: 10.1016/j.ejca.2014.06.020. Epub 2014 Jul 21. PMID: 25060825.
  3. Ghadimi M, Rödel C, Hofheinz R, Flebbe H, Grade M. Multimodal Treatment of Rectal Cancer. Dtsch Arztebl Int. 2022 Aug 22;119(33-34):570-580. doi: 10.3238/arztebl.m2022.0254. PMID: 35791271; PMCID: PMC9743213.
  4. Luo B, Fan C, Xie X, Loftås P, Sun XF. Preoperative Radiotherapy Decision-Tree for Rectal Cancer Patients: A Real-World Analysis Based on the Swedish Colorectal Cancer Registry. Clin Colorectal Cancer. 2023 Sep;22(3):280-290. doi: 10.1016/j.clcc.2023.04.001. Epub 2023 May 14. PMID: 37270356.
  5. Haber L, Allen A, Rune KT. Sexual quality of life following a cancer diagnosis: a qualitative study. Support Care Cancer. 2023 Jan 21;31(2):125. doi: 10.1007/s00520-022-07459-8. PMID: 36680658; PMCID: PMC9860240.
  6. Sörensson M, Asplund D, Matthiessen P, Rosenberg J, Hallgren T, Rosander C, González E, Bock D, Angenete E. Self-reported sexual dysfunction in patients with rectal cancer. Colorectal Dis. 2020 May;22(5):500-512. doi: 10.1111/codi.14907. Epub 2019 Dec 6. PMID: 31713295; PMCID: PMC7317395.
  7. Hansen SB, Oggesen BT, Fonnes S, Rosenberg J. Erectile Dysfunction Is Common after Rectal Cancer Surgery: A Cohort Study. Curr Oncol. 2023 Oct 20;30(10):9317-9326. doi: 10.3390/curroncol30100673. PMID: 37887573; PMCID: PMC10605730.
  8. Costa P, Cardoso JM, Louro H, Dias J, Costa L, Rodrigues R, Espiridião P, Maciel J, Ferraz L. Impact on sexual function of surgical treatment in rectal cancer. Int Braz J Urol. 2018 Jan-Feb;44(1):141-149. doi: 10.1590/S1677-5538.IBJU.2017.0318. PMID: 29219281; PMCID: PMC5815544.
  9. De Felice F, Marchetti C, Marampon F, Cascialli G, Muzii L, Tombolini V. Radiation effects on male fertility. Andrology. 2019 Jan;7(1):2-7. doi: 10.1111/andr.12562. Epub 2018 Nov 9. PMID: 30411532.
  10. Fukunaga H, Yokoya A, Prise KM. A Brief Overview of Radiation-Induced Effects on Spermatogenesis and Oncofertility. Cancers (Basel). 2022 Feb 4;14(3):805. doi: 10.3390/cancers14030805. PMID: 35159072; PMCID: PMC8834293.
  11. Jia SB, Soleimani A, Mirsadraee M, Zarifi S, Sanaeifar E. Evaluation of the effectiveness of testicular shielding in rectal cancer radiotherapy. Radiation Physics and Chemistry. 2023 Jan 1;202:110435. doi: 10.1016/j.radphyschem.2022.110435.
  12. Singhal MK, Kapoor A, Singh D, Bagri PK, Narayan S, Nirban RK, Kumar HS. Scattered radiation to gonads: role of testicular shielding for para-aortic and homolateral illiac nodal radiotherapy. J Egypt Natl Canc Inst. 2014 Jun;26(2):99-101. doi: 10.1016/j.jnci.2014.03.002. Epub 2014 Mar 31. PMID: 24841161.
  13. Rödel C. ASTRO Clinical Practice Statement for the appropriate customization of radiation therapy for rectal cancer: A European perspective. Pract Radiat Oncol. 2016 May-Jun;6(3):e49-e51. doi: 10.1016/j.prro.2016.01.005. Epub 2016 Jan 12. PMID: 26952814.
  14. Wo JY, Anker CJ, Ashman JB, Bhadkamkar NA, Bradfield L, Chang DT, Dorth J, Garcia-Aguilar J, Goff D, Jacqmin D, Kelly P, Newman NB, Olsen J, Raldow AC, Ruiz-Garcia E, Stitzenberg KB, Thomas CR Jr, Wu QJ, Das P. Radiation Therapy for Rectal Cancer: Executive Summary of an ASTRO Clinical Practice Guideline. Pract Radiat Oncol. 2021 Jan-Feb;11(1):13-25. doi: 10.1016/j.prro.2020.08.004. Epub 2020 Oct 21. PMID: 33097436.
  15. Wang X, Ji X. Sample Size Estimation in Clinical Research: From Randomized Controlled Trials to Observational Studies. Chest. 2020 Jul;158(1S):S12-S20. doi: 10.1016/j.chest.2020.03.010. PMID: 32658647.
  16. Gul OV, Basaran H, Inan G. Evaluation of incidental testicular dose with thermoluminescence dosimetry during prostate radiotherapy. Med Dosim. 2022 Autumn;47(3):203-206. doi: 10.1016/j.meddos.2022.02.007. Epub 2022 Mar 12. PMID: 35287998.
  17. Farhood B, Mortezaee K, Haghi-Aminjan H, Khanlarkhani N, Salehi E, Nashtaei MS, Najafi M, Sahebkar A. A systematic review of radiation-induced testicular toxicities following radiotherapy for prostate cancer. J Cell Physiol. 2019 Sep;234(9):14828-14837. doi: 10.1002/jcp.28283. Epub 2019 Feb 10. PMID: 30740683.
  18. Georgakopoulos I, Kouloulias V, Ntoumas GN, Desse D, Koukourakis I, Kougioumtzopoulou A, Kanakis G, Zygogianni A. Radiotherapy and Testicular Function: A Comprehensive Review of the Radiation-Induced Effects with an Emphasis on Spermatogenesis. Biomedicines. 2024 Jul 5;12(7):1492. doi: 10.3390/biomedicines12071492. PMID: 39062064; PMCID: PMC11274587.
  19. Sourati A, Malekzadeh M, Bakhshandeh M, Moosavizadeh A, Azma Z. Evaluation of Relationship Between Testicular Dose and Hormonal Changes After Radiotherapy in Patients With Rectal Cancer.Rep Radiother Oncol.2015 Jan 28;2(1). doi: 10.5812/rro.885.
  20. Frøseth TC, Strickert T, Solli KS, Salvesen Ø, Frykholm G, Reidunsdatter RJ. A randomized study of the effect of patient positioning on setup reproducibility and dose distribution to organs at risk in radiotherapy of rectal cancer patients. Radiat Oncol. 2015 Oct 27;10:217. doi: 10.1186/s13014-015-0524-3. PMID: 26508131; PMCID: PMC4624657.
  21. Yang Y, Cai S, Zhao T, Peng Q, Qian J, Tian Y. Effect of prone and supine treatment positions for postoperative treatment of rectal cancer on target dose coverage and small bowel sparing using intensity-modulated radiation therapy. Transl Cancer Res. 2020 Feb;9(2):491-499. doi: 10.21037/tcr.2019.11.33. PMID: 35117393; PMCID: PMC8799155.
  22. Kim A, Karotki A, Presutti J, Gonzales G, Wong S, Chu W. The effect of prone and supine treatment positions for the pre-operative treatment of rectal cancer on organ-at-risk sparing and setup reproducibility using volumetric modulated arc therapy. Radiat Oncol. 2017 Dec 5;12(1):180. doi: 10.1186/s13014-017-0918-5. PMID: 29202879; PMCID: PMC5715653.
 

 

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