LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,243
تعداد مقالات11,320
تعداد مشاهده مقاله81,228,825
تعداد دریافت فایل اصل مقاله116,755,889
Rasul, Khder, Hasan, Bestoon, Barzngy, Basak, Housein, Zjwan, Salihi, Abbas. (1405). An In-Depth Analysis of Colorectal Cancer in Erbil: Demographic Factors, Regional Disparities, Treatment Approaches and Genetic Studies. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/mejc.2025.103890.2157
Khder H Rasul; Bestoon Hasan; Basak Barzngy; Zjwan Housein; Abbas Salihi. "An In-Depth Analysis of Colorectal Cancer in Erbil: Demographic Factors, Regional Disparities, Treatment Approaches and Genetic Studies". سامانه مدیریت نشریات علمی, , , 1405, -. doi: 10.30476/mejc.2025.103890.2157
Rasul, Khder, Hasan, Bestoon, Barzngy, Basak, Housein, Zjwan, Salihi, Abbas. (1405). 'An In-Depth Analysis of Colorectal Cancer in Erbil: Demographic Factors, Regional Disparities, Treatment Approaches and Genetic Studies', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/mejc.2025.103890.2157
Rasul, Khder, Hasan, Bestoon, Barzngy, Basak, Housein, Zjwan, Salihi, Abbas. An In-Depth Analysis of Colorectal Cancer in Erbil: Demographic Factors, Regional Disparities, Treatment Approaches and Genetic Studies. سامانه مدیریت نشریات علمی, 1405; (): -. doi: 10.30476/mejc.2025.103890.2157

An In-Depth Analysis of Colorectal Cancer in Erbil: Demographic Factors, Regional Disparities, Treatment Approaches and Genetic Studies

Middle East Journal of Cancer
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 12 فروردین 1405    اصل مقاله (759.19 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2025.103890.2157
نویسندگان
Khder H Rasul* 1؛ Bestoon Hasan2؛ Basak Barzngy2؛ Zjwan Housein3؛ Abbas Salihi4
1Department of Biology, College of Science, Salahaddin University-Erbil, Erbil, Kurdistan Region, Iraq. Medical Analysis Department, Tishk International University, Erbil, Iraq.
2Department of Cancer Registry, Cancer Control Unit, Erbil Directorate of Health, Erbil, Iraq
3Department of Medical Laboratory Technology, Technical Health and Medical College, Erbil Polytechnic University, Erbil, Kurdistan Region 44002, Iraq.
4Department of Biology, College of Science, Salahaddin University-Erbil, Erbil, Kurdistan Region, Iraq. Center of Research and Strategic Studies, Lebanese French University, Erbil, Iraq.
چکیده
Aim: This study explores sex, age, histological subtype, cancer stages, treatment methods and genetic studies (mutation and expression) of Adenomatous Polyposis Coli (APC), Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS), Tumor Protein 53 (TP53) and Deleted in Colorectal Cancer (DCC) genes for colorectal cancer (CRC).
Method: In this retrospective research study, 2625 CRC patients were included. The study spanned eleven years, from 2013 to 2023, and revealed fascinating trends and patterns within each category. GraphPad Prism version 9.0. (GraphPad Software, Inc.) was used to analyze acquired data. T test was used for the comparison between two groups. A P-value of 0.05 or below was considered statistically significant. 
Results: The data demonstrate a considerable rise in CRC incidences throughout the study's period, peaking in 2021 and men outnumbered women annually. The age-based analysis showed individuals of all ages were vulnerable to CRC, with the number of cases rising until peaking at 60. Histologically, colon cancer was more common than rectal cancer, and adenocarcinoma was the most common subtype. Most cases were grade 2 based on Tumor (T), Node (N) and Metastasis (M) staging system, with T3N1M0 and T3N2M0 being the most prevalent subtypes. The majority CRC patients received curative treatments. Regarding genetic studies of CRC related APC, KRAS, TP53 and DCC genes in International Cancer Genome Consortium databases, APC had the most mutations, with single-base substitutions being predominant. In the Catalogue of Somatic Mutations in Cancer database, KRAS had the highest mutations which included 8 missense substitutions. Regarding gene expression, public database Gene Expression Database of Normal and Tumor Tissues 2 showed significant differences between the four selected genes in CRC as compared with the normal tissue.
Conclusion: The study results highlight the complex nature of CRC and its prevalence and treatment. The genetic studies of CRC in databases revealed that APC and KRAS had the most mutations and gene expression analysis indicated significant differences between CRC and normal tissue for the selected genes.

تازه های تحقیق

Bestoon Hasan (google scholar)

Khder Rasul (google scholar)

کلیدواژه‌ها
CRC؛ APC gene؛ KRAS gene؛ TP53 gene؛ DCC gene
مراجع
  1. Xi Y, Xu P. Global colorectal cancer burden in 2020 and projections to 2040. Transl Oncol. 2021 Oct;14(10):101174. doi: 10.1016/j.tranon.2021.101174. Epub 2021 Jul 6. PMID: 34243011; PMCID: PMC8273208.
  2. Siegel RL, Wagle NS, Cercek A, Smith RA, Jemal A. Colorectal cancer statistics, 2023. CA Cancer J Clin. 2023 May-Jun;73(3):233-254. doi: 10.3322/caac.21772. Epub 2023 Mar 1. PMID: 36856579.
  3. Sawicki T, Ruszkowska M, Danielewicz A, Niedźwiedzka E, Arłukowicz T, Przybyłowicz KE. A Review of Colorectal Cancer in Terms of Epidemiology, Risk Factors, Development, Symptoms and Diagnosis. Cancers. 2021;13:2025. PubMed PMID: doi:10.3390/cancers13092025.
  4. Ibrahem S, Ahmed H, Zangana S. Trends in colorectal cancer in Iraq over two decades: incidence, mortality, topography and morphology. Ann Saudi Med. 2022;42:252-61. doi: 10.5144/0256-4947.2022.252. PubMed PMID: 35933610; PubMed Central PMCID: PMCPMC9357297.
  5. Sninsky JA, Shore BM, Lupu GV, Crockett SD. Risk Factors for Colorectal Polyps and Cancer. Gastrointest Endosc Clin N Am. 2022;32:195-213. doi: 10.1016/j.giec.2021.12.008. PubMed PMID: 35361331.
  6. Lewandowska A, Rudzki G, Lewandowski T, Stryjkowska-Góra A, Rudzki S. Title: Risk Factors for the Diagnosis of Colorectal Cancer. Cancer Control. 2022;29:10732748211056692. doi: 10.1177/10732748211056692. PubMed PMID: 35000418; PubMed Central PMCID: PMCPMC8753079.
  7. Johnson CM, Wei C, Ensor JE, Smolenski DJ, Amos CI, Levin B, et al. Meta-analyses of colorectal cancer risk factors. Cancer Causes & Control. 2013;24:1207-22. doi: 10.1007/s10552-013-0201-5.
  8. Dekker E, Tanis PJ, Vleugels JLA, Kasi PM, Wallace MB. Colorectal cancer. Lancet. 2019;394:1467-80. doi: 10.1016/s0140-6736(19)32319-0. PubMed PMID: 31631858.
  9. Jiao S, Peters U, Berndt S, Brenner H, Butterbach K, Caan BJ, et al. Estimating the heritability of colorectal cancer. Hum Mol Genet. 2014;23:3898-905. doi: 10.1093/hmg/ddu087. PubMed PMID: 24562164; PubMed Central PMCID: PMCPMC4065150.
  10. Mármol I, Sánchez-de-Diego C, Pradilla Dieste A, Cerrada E, Rodriguez Yoldi MJ. Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer. International Journal of Molecular Sciences. 2017;18:197. PubMed PMID: doi:10.3390/ijms18010197.
  11. Fonseca AS, Ramão A, Bürger MC, de Souza JES, Zanette DL, de Molfetta GA, et al. ETV4 plays a role on the primary events during the adenoma-adenocarcinoma progression in colorectal cancer. BMC Cancer. 2021;21:207. doi: 10.1186/s12885-021-07857-x. PubMed PMID: 33648461; PubMed Central PMCID: PMCPMC7919324.
  12. Delahunt B, Eble JN, Samaratunga H, Thunders M, Yaxley JW, Egevad L. Staging of renal cell carcinoma: current progress and potential advances. Pathology. 2021;53:120-8. doi: 10.1016/j.pathol.2020.08.007.
  13. Hamadamin PS, Maulood KA. Exploring the anticancer potential of hydrogen sulfide and BAY‑876 on clear cell renal cell carcinoma cells: Uncovering novel mutations in VHL and KDR genes among ccRCC patients. Mol Clin Oncol. 2024;20:21. doi: 10.3892/mco.2024.2719. PubMed PMID: 38332991; PubMed Central PMCID: PMCPMC10851183.
  14. Gudmundsson S, Singer-Berk M, Watts NA, Phu W, Goodrich JK, Solomonson M, et al. Variant interpretation using population databases: Lessons from gnomAD. Hum Mutat. 2022;43:1012-30. doi: 10.1002/humu.24309. PubMed PMID: 34859531; PubMed Central PMCID: PMCPMC9160216.
  15. Hamadamin PS, Maulood KA. Exploring the anticancer potential of hydrogen sulfide and BAY‑876 on clear cell renal cell carcinoma cells: Uncovering novel mutations in VHL and KDR genes among ccRCC patients. Molecular and Clinical Oncology. 2024;20:1-12.
  16. Franz M, Rodriguez H, Lopes C, Zuberi K, Montojo J, Bader GD, et al. GeneMANIA update 2018. Nucleic Acids Res. 2018;46:W60-w4. doi: 10.1093/nar/gky311. PubMed PMID: 29912392; PubMed Central PMCID: PMCPMC6030815.
  17. Sondka Z, Bamford S, Cole CG, Ward SA, Dunham I, Forbes SA. The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers. Nat Rev Cancer. 2018;18:696-705. doi: 10.1038/s41568-018-0060-1. PubMed PMID: 30293088; PubMed Central PMCID: PMCPMC6450507.
  18. Abdulrahman AS, Rasul KH, Mustafa IA, Abdulqadir SZ. In vitro anti-cancer potentiality of quince and dandelion leaves extract against leukemia cell lines and database retrieval expression of BCR ABL and TCR genes in leukemia. Immunopathologia Persa. 2025.
  19. M-Amen K, Abdullah OS, Amin AMS, Mohamed ZA, Hasan B, Shekha M, et al. Cancer Incidence in the Kurdistan Region of Iraq: Results of a Seven-Year Cancer Registration in Erbil and Duhok Governorates. Asian Pac J Cancer Prev. 2022;23:601-15. doi: 10.31557/apjcp.2022.23.2.601. PubMed PMID: 35225473; PubMed Central PMCID: PMCPMC9272643.
  20. Wong MCS, Huang J, Lok V, Wang J, Fung F, Ding H, et al. Differences in Incidence and Mortality Trends of Colorectal Cancer Worldwide Based on Sex, Age, and Anatomic Location. Clin Gastroenterol Hepatol. 2021;19:955-66.e61. doi: 10.1016/j.cgh.2020.02.026. PubMed PMID: 32088300.
  21. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians. 2021;71:209-49. doi: https://doi.org/10.3322/caac.21660.
  22. Majek O, Gondos A, Jansen L, Emrich K, Holleczek B, Katalinic A, et al. Sex differences in colorectal cancer survival: population-based analysis of 164,996 colorectal cancer patients in Germany. PLoS One. 2013;8:e68077. doi: 10.1371/journal.pone.0068077. PubMed PMID: 23861851; PubMed Central PMCID: PMCPMC3702575.
  23. Keum N, Giovannucci E. Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies. Nature Reviews Gastroenterology & Hepatology. 2019;16:713-32. doi: 10.1038/s41575-019-0189-8.
  24. Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Prz Gastroenterol. 2019;14:89-103. doi: 10.5114/pg.2018.81072. PubMed PMID: 31616522; PubMed Central PMCID: PMCPMC6791134.
  25. Vuik FE, Nieuwenburg SA, Bardou M, Lansdorp-Vogelaar I, Dinis-Ribeiro M, Bento MJ, et al. Increasing incidence of colorectal cancer in young adults in Europe over the last 25 years. Gut. 2019;68:1820-6. doi: 10.1136/gutjnl-2018-317592.
  26. Done JZ, Fang SH. Young-onset colorectal cancer: A review. World J Gastrointest Oncol. 2021;13:856-66. doi: 10.4251/wjgo.v13.i8.856. PubMed PMID: 34457191; PubMed Central PMCID: PMCPMC8371519.
  27. Mueller M, Schneider MA, Deplazes B, Cabalzar-Wondberg D, Rickenbacher A, Turina M. Colorectal cancer of the young displays distinct features of aggressive tumor biology: A single-center cohort study. World J Gastrointest Surg. 2021;13:164-75. doi: 10.4240/wjgs.v13.i2.164. PubMed PMID: 33643536; PubMed Central PMCID: PMCPMC7898186.
  28. Offermans NS, Vermeulen R, Burdorf A, Goldbohm RA, Keszei AP, Peters S, et al. Occupational asbestos exposure and risk of esophageal, gastric and colorectal cancer in the prospective Netherlands Cohort Study. Int J Cancer. 2014;135:1970-7. doi: 10.1002/ijc.28817. PubMed PMID: 24585528.
  29. Carethers JM, Doubeni CA. Causes of Socioeconomic Disparities in Colorectal Cancer and Intervention Framework and Strategies. Gastroenterology. 2020;158:354-67. doi: 10.1053/j.gastro.2019.10.029. PubMed PMID: 31682851; PubMed Central PMCID: PMCPMC6957741.
  30. Duijster J, Mughini-Gras L, Neefjes J, Franz E. Occupational exposure and risk of colon cancer: a nationwide registry study with emphasis on occupational exposure to zoonotic gastrointestinal pathogens. BMJ Open. 2021;11:e050611. doi: 10.1136/bmjopen-2021-050611.
  31. Al-Azri M, Al-Maskari A, Al-Matroushi S, Al-Awisi H, Davidson R, Panchatcharam SM, et al. Awareness of Cancer Symptoms and Barriers to Seeking Medical Help Among Adult People Attending Primary Care Settings in Oman. Health Serv Res Manag Epidemiol. 2016;3:2333392816673290. doi: 10.1177/2333392816673290. PubMed PMID: 28462284; PubMed Central PMCID: PMCPMC5266467.
  32. Allemani C, Matsuda T, Di Carlo V, Harewood R, Matz M, Nikšić M, et al. Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet. 2018;391:1023-75. doi: 10.1016/s0140-6736(17)33326-3. PubMed PMID: 29395269; PubMed Central PMCID: PMCPMC5879496.
  33. Hossain MS, Karuniawati H, Jairoun AA, Urbi Z, Ooi J, John A, et al. Colorectal Cancer: A Review of Carcinogenesis, Global Epidemiology, Current Challenges, Risk Factors, Preventive and Treatment Strategies. Cancers (Basel). 2022;14. doi: 10.3390/cancers14071732. PubMed PMID: 35406504; PubMed Central PMCID: PMCPMC8996939.
  34. Ramadhan IA, Sulaiman LR, Salihi A. NOS3 and CTH gene mutations as new molecular markers for detection of lung adenocarcinoma. PeerJ. 2023;11:e16209.
  35. Housein Z, Kareem TS, Salihi A. In vitro anticancer activity of hydrogen sulfide and nitric oxide alongside nickel nanoparticle and novel mutations in their genes in CRC patients. Scientific Reports. 2021;11:2536.
  36. Zhang L, Shay JW. Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer. J Natl Cancer Inst. 2017;109. doi: 10.1093/jnci/djw332. PubMed PMID: 28423402; PubMed Central PMCID: PMCPMC5963831.
  37. Zhu G, Pei L, Xia H, Tang Q, Bi F. Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer. Mol Cancer. 2021;20:143. doi: 10.1186/s12943-021-01441-4. PubMed PMID: 34742312; PubMed Central PMCID: PMCPMC8571891.
  38. Liebl MC, Hofmann TG. The Role of p53 Signaling in Colorectal Cancer. Cancers (Basel). 2021;13. doi: 10.3390/cancers13092125. PubMed PMID: 33924934; PubMed Central PMCID: PMCPMC8125348.
  39. Márquez-González RM, Saucedo-Sariñana AM, de Jesús Tovar-Jacome C, Barros-Núñez P, Gallegos-Arreola MP, Orozco-Gutiérrez MH, et al. NME1 and DCC variants are associated with susceptibility and tumor characteristics in Mexican patients with colorectal cancer. J Egypt Natl Canc Inst. 2024;36:10. doi: 10.1186/s43046-024-00213-7. PubMed PMID: 38556604.
 

 

آمار
تعداد مشاهده مقاله: 4
تعداد دریافت فایل اصل مقاله: 1


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب