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Association between Serum Vitamin D Levels and VDR BsmI Polymorphism in Temporomandibular Joint Dysfunction Patients (in the Iranian Population) | ||
| Journal of Dentistry | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 03 دی 1404 اصل مقاله (676.79 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/dentjods.2025.106238.2644 | ||
| نویسندگان | ||
| Maryam Mostafavi1؛ Fahimeh Rezazadeh* 2؛ Mohammad Javad Fattahi3؛ Fatemeh Tavakoli4؛ Abbas Ghaderi3 | ||
| 1Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 2Oral and Dental Disease Research Center, Dept. of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 3Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 4University at Buffalo, Oral Biology, Surgery and Biomedical Engineering, Buffalo, New York, USA. | ||
| چکیده | ||
| Background: Multiple studies have revealed an association between vitamin D levels, genetic polymorphisms of the VDR (vitamin D receptor) gene, and the underlying causes of various bone and cartilage disorders. Purpose: This study aimed to investigate the association between the BsmI polymorphism of the VDR gene and serum vitamin D levels in a group of temporomandibular joint dysfunction (TMD) patients compared to healthy controls. Materials and Method: Our cross-sectional study encompassed 42 TMD patients diagnosed according to the research diagnostic criteria for temporomandibular disorders (RDC /TMD) and 41 healthy subjects. Genomic DNA was prepared, the BsmI variant was analyzed by PCR-RFLP, and the serum vitamin D level was measured by ELISA technique. Chi square and ANOVA test was used for analysis and statistical significance was set at p Value < 0.05. Results: The serum levels of vitamin D in the TMD group were significantly lower than those in the control group, with values of 43.52±18.16 ng/mL compared to 57.56±21.29 ng/mL (p= 0.002). The prevalence of vitamin D insufficiency was remarkably higher in the patients than in the controls, at 26.19% vs. 4.87%, respectively (p= 0.008). Our analysis revealed no significant differences in the genotype and allele frequencies of the VDR BsmI variant between TMD patients and controls (p= 0.475 and p= 1.000, respectively). Additionally, our study found no significant association between the genotypes of the VDR BsmI variant and vitamin D status (p= 0.363). Conclusion: Monitoring vitamin D levels in TMD patients is important, as deficiency may impact disease development. Further research is needed on the role of vitamin D and VDR gene variants in managing temporomandibular disorders. | ||
| کلیدواژهها | ||
| Temporomandibular Joint Disorder؛ Vitamin D؛ Serum؛ Receptors؛ Calcitriol؛ Insufficiency | ||
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