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Sattarinezhad, Elahe, Mowlazadeh Haghighi, Saghar, Purkhosrow, Azar, Oftadehgan, Somayeh, Asrari, Zeinab, Khalafinezhad, Ali. (1404). Highly Efficient Synthesis of Vasorelaxant Quinazolinone Derivatives under Ultrasonic Irradiation in the Presence of TiO2 Nanoparticles. سامانه مدیریت نشریات علمی, 11(4), -. doi: 10.30476/tips.2025.106987.1297
Elahe Sattarinezhad; Saghar Mowlazadeh Haghighi; Azar Purkhosrow; Somayeh Oftadehgan; Zeinab Asrari; Ali Khalafinezhad. "Highly Efficient Synthesis of Vasorelaxant Quinazolinone Derivatives under Ultrasonic Irradiation in the Presence of TiO2 Nanoparticles". سامانه مدیریت نشریات علمی, 11, 4, 1404, -. doi: 10.30476/tips.2025.106987.1297
Sattarinezhad, Elahe, Mowlazadeh Haghighi, Saghar, Purkhosrow, Azar, Oftadehgan, Somayeh, Asrari, Zeinab, Khalafinezhad, Ali. (1404). 'Highly Efficient Synthesis of Vasorelaxant Quinazolinone Derivatives under Ultrasonic Irradiation in the Presence of TiO2 Nanoparticles', سامانه مدیریت نشریات علمی, 11(4), pp. -. doi: 10.30476/tips.2025.106987.1297
Sattarinezhad, Elahe, Mowlazadeh Haghighi, Saghar, Purkhosrow, Azar, Oftadehgan, Somayeh, Asrari, Zeinab, Khalafinezhad, Ali. Highly Efficient Synthesis of Vasorelaxant Quinazolinone Derivatives under Ultrasonic Irradiation in the Presence of TiO2 Nanoparticles. سامانه مدیریت نشریات علمی, 1404; 11(4): -. doi: 10.30476/tips.2025.106987.1297

Highly Efficient Synthesis of Vasorelaxant Quinazolinone Derivatives under Ultrasonic Irradiation in the Presence of TiO2 Nanoparticles

Trends in Pharmaceutical Sciences and Technologies
مقاله 4، دوره 11، شماره 4 - شماره پیاپی 44، اسفند 2025
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2025.106987.1297
نویسندگان
Elahe Sattarinezhad* 1؛ Saghar Mowlazadeh Haghighi2؛ Azar Purkhosrow1؛ Somayeh Oftadehgan1؛ Zeinab Asrari2؛ Ali Khalafinezhad2
1Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Chemistry, Shiraz University, Shiraz, Iran
چکیده
Quinazolinone compounds are interesting pharmacophores with a wide range of biological activities. Among the most valuable quinazolinones are the 3-substituted 2-methylquinazolin-4(3H)-one derivatives. There are some reports about the vasorelaxant effects of these compounds.Various methods have been suggested to synthesize these molecules, but most of them suffer from many disadvantages such as long reaction times, low yields, harsh reaction conditions, and toxic residues. Therefore, developing convenient methods for the synthesis of these valuable medicinal scaffolds is of great importance. In the first part of this study, we presented an efficient procedure for the preparation of a series of 3-substituted 2-methylquinazolin-4(3H)-one derivatives from anthranilic acid, acetic anhydride and primary amines using TiO2 nanoparticles under ultrasonic irradiation in solvent-free conditions at room temperature. In the second part of this research, we analyzed the vasorelaxant activity of the synthesized compounds in isolated rat thoracic aorta. Based on the results, all of the synthesized quinazolinone derivatives showed vasorelaxant properties and some of them were as potent as acetylcholine.
کلیدواژه‌ها
Quinazolinones؛ Ultrasonics؛ Vasorelaxant؛ Nanoparticles؛ Titanium dioxide
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تعداد مشاهده مقاله: 14


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