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Mowlazadeh Haghighi, Saghar, Purkhosrow, Azar, Oftadehgan, Somayeh, Asrari, Zeinab, Khalafinezhad, Ali, Sattarinezhad, Elahe. (1404). Highly Efficient Synthesis of Vasorelaxant Quinazolinone Derivatives under Ultrasonic Irradiation in the Presence of TiO2 Nanoparticles. سامانه مدیریت نشریات علمی, 11(4), 321-332. doi: 10.30476/tips.2025.106987.1297
Saghar Mowlazadeh Haghighi; Azar Purkhosrow; Somayeh Oftadehgan; Zeinab Asrari; Ali Khalafinezhad; Elahe Sattarinezhad. "Highly Efficient Synthesis of Vasorelaxant Quinazolinone Derivatives under Ultrasonic Irradiation in the Presence of TiO2 Nanoparticles". سامانه مدیریت نشریات علمی, 11, 4, 1404, 321-332. doi: 10.30476/tips.2025.106987.1297
Mowlazadeh Haghighi, Saghar, Purkhosrow, Azar, Oftadehgan, Somayeh, Asrari, Zeinab, Khalafinezhad, Ali, Sattarinezhad, Elahe. (1404). 'Highly Efficient Synthesis of Vasorelaxant Quinazolinone Derivatives under Ultrasonic Irradiation in the Presence of TiO2 Nanoparticles', سامانه مدیریت نشریات علمی, 11(4), pp. 321-332. doi: 10.30476/tips.2025.106987.1297
Mowlazadeh Haghighi, Saghar, Purkhosrow, Azar, Oftadehgan, Somayeh, Asrari, Zeinab, Khalafinezhad, Ali, Sattarinezhad, Elahe. Highly Efficient Synthesis of Vasorelaxant Quinazolinone Derivatives under Ultrasonic Irradiation in the Presence of TiO2 Nanoparticles. سامانه مدیریت نشریات علمی, 1404; 11(4): 321-332. doi: 10.30476/tips.2025.106987.1297

Highly Efficient Synthesis of Vasorelaxant Quinazolinone Derivatives under Ultrasonic Irradiation in the Presence of TiO2 Nanoparticles

Trends in Pharmaceutical Sciences and Technologies
مقاله 4، دوره 11، شماره 4 - شماره پیاپی 44، اسفند 2025، صفحه 321-332    اصل مقاله (542.49 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2025.106987.1297
نویسندگان
Saghar Mowlazadeh Haghighi1؛ Azar Purkhosrow2؛ Somayeh Oftadehgan2؛ Zeinab Asrari1؛ Ali Khalafinezhad1؛ Elahe Sattarinezhad* 2
1Department of Chemistry, Shiraz University, Shiraz, Iran
2Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Quinazolinone compounds are interesting pharmacophores with a wide range of biological activities. Among the most valuable quinazolinones are the 3-substituted 2-methylquinazolin-4(3H)-one derivatives. There are some reports about the vasorelaxant effects of these compounds.Various methods have been suggested to synthesize these molecules, but most of them suffer from many disadvantages such as long reaction times, low yields, harsh reaction conditions, and toxic residues. Therefore, developing convenient methods for the synthesis of these valuable medicinal scaffolds is of great importance. In the first part of this study, we presented an efficient procedure for the preparation of a series of 3-substituted 2-methylquinazolin-4(3H)-one derivatives from anthranilic acid, acetic anhydride and primary amines using TiO2 nanoparticles under ultrasonic irradiation in solvent-free conditions at room temperature. In the second part of this research, we analyzed the vasorelaxant activity of the synthesized compounds in isolated rat thoracic aorta. Based on the results, all of the synthesized quinazolinone derivatives showed vasorelaxant properties and some of them were as potent as acetylcholine.

تازه های تحقیق

Saghar Mowlazadeh Haghighi (Google Scholar)

Elahe Sattarinezhad (Google Scholar)

کلیدواژه‌ها
Quinazolinones؛ Ultrasonics؛ Vasorelaxant؛ Nanoparticles؛ Titanium dioxide
مراجع
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