| تعداد نشریات | 20 |
| تعداد شمارهها | 1,262 |
| تعداد مقالات | 11,502 |
| تعداد مشاهده مقاله | 81,854,839 |
| تعداد دریافت فایل اصل مقاله | 120,988,230 |
Human Papillomavirus in Colorectal Cancer: from Molecular Mechanisms to Clinical Implications and Therapeutic Strategies | ||
| Iranian Journal of Colorectal Research | ||
| مقاله 2، دوره 13، شماره 3، آذر 2025، صفحه 84-91 اصل مقاله (1.3 M) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.30476/acrr.2025.108892.1270 | ||
| نویسندگان | ||
| Pouria Rahemi1؛ Sayyid Ali Hosseini* 1؛ Mahdieh Hoseinpour1؛ Mahdi Farasati2 | ||
| 1Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| چکیده | ||
| Colorectal cancer (CRC) is a leading cause of cancer-related mortality, and its incidence is increasing. Although the causes are multifactorial, a growing body of evidence implicates human papillomavirus (HPV) as a potential contributor in some cases. This review synthesizes current knowledge by comprehensively analyzing literature retrieved from PubMed gateway, Scopus database, and Google Scholar search engine, covering publications from 2020 to 2025. We examine molecular evidence demonstrating how the viral oncoproteins E6 and E7 disrupt key cellular defenses by targeting p53 and pRb. This mechanism can induce genomic instability and interfere with critical signaling pathways. Based on studies detecting the virus in colorectal tissues, the concept of HPVpositive CRC as a distinct clinical entity is gaining traction. Such a finding would have significant implications for prognosis and immunotherapy treatment. If a causal relationship is established, HPV vaccination could become an essential tool for CRC prevention, and novel therapies targeting the virus may emerge. However, important questions remain: the field must standardize diagnostic methods, definitively prove causation, and identify reliable biomarkers to improve patient outcomes. | ||
تازه های تحقیق | ||
Pouria Rahemi (Google Scholar) Sayyid Ali Hosseini (Google Scholar) | ||
| کلیدواژهها | ||
| Colorectal Neoplasms؛ Papillomavirus, Human؛ Carcinogenesis؛ Immunotherapy؛ Prognosis | ||
| مراجع | ||
|
1. Mousavi SE, Ilaghi M, Hamidi Rad R, et al. Epidemiology and socioeconomic correlates of colorectal cancer in Asia in 2020 and its projection to 2040. Scientific reports. 2025;15(1):26639. 2. Zhao J, Ji H, Li K, et al. Decoding the genetic and environmental forces in propelling the surge of early-onset colorectal cancer. Chinese medical journal. 2025;138(10):1163-74. 3. Khan A, Hasana U, Nadeem IA, et al. Advances in colorectal cancer screening and detection: a narrative review on biomarkers, imaging and preventive strategies. Journal of the Egyptian National Cancer Institute. 2025;37(1):20. 4. Fan A, Wang B, Wang X, et al. Immunotherapy in colorectal cancer: current achievements and future perspective. International journal of biological sciences. 2021;17(14):3837-49. 5. Javadi M, Jalilian S, Kanani M, et al. Time to take HPV infection in colorectal cancer patients more seriously. Frontiers in Medicine. 2024;11:1418359. 6. Basnet U. Stress-Survival Pathway Genes In Colorectal Cancer: Crc Progression And Hispanic Disparities, Highlighting Mcm10 As A Potential Player: The University of Texas at El Paso; 2025. 7. Haverkamp D, Melkonian SC, Jim MA. Growing disparity in the incidence of colorectal cancer among non-Hispanic American Indian and Alaska Native populations— United States, 2013–2017. Cancer Epidemiology, Biomarkers & Prevention. 2021;30(10):1799-806. 8. Giaquinto AN, Miller KD, Tossas KY, et al. Cancer statistics for African American/black people 2022. CA: a cancer journal for clinicians. 2022;72(3):202-29. 9. Fang C, Shi W, Qiao Y, et al. Construction of a risk factor prediction model for postoperative complications in elderly patients with colorectal cancer using machine learning. Journal of Robotic Surgery. 2025;19(1):1-11. 10. Goldberg D, Pettke E, editors. Global Perspectives on Young-Onset Colorectal Cancer: Epidemiology, Challenges, and Advances. Seminars in Colon and Rectal Surgery; 2025: Elsevier. 11. Ibrahim SM. Pathology of Colorectal Cancer: Microscopic Analysis, Staging, and Classification. Advancements in Colorectal Cancer: CRC Press. p. 9-31. 12. Prashanth K, Hanumantharayappa B. a comprehensive review on treatment of types of colorectal cancer. 2025. 13. Hanft W, Stankiewicz Karita H, Khorsandi N, et al. Sexually transmitted human papillomavirus and related sequelae. Clinical M i c r o b i ol o g y R e v i e w s . 2025;38(1):e00085-23. 14. Sofiani VH, Veisi P, Rukerd MRZ, et al. The complexity of human papilloma virus in cancers: a narrative review. Infectious Agents and Cancer. 2023;18(1):13. 15. Schwerdt A. Value of circulating tumor cell DNA in HPV-associated anal carcinoma for monitoring treatment effects and detection of disease relapses after treatment with definitive chemoradiation: University of Split. School of Medicine; 2024. 16. Cosper PF, Bradley S, Luo Q, et al. Biology of HPV mediated carcinogenesis and tumor progression. Seminars in radiation oncology; 2021: Elsevier. 17. Fernandes Q, Inchakalody VP, Mestiri S, et al. Crosstalk Between the Oncoproteins of High‐Risk Human Papillomaviruses Types 16 and 18 in Colorectal Cancer Cell Models. Cancer Reports. 2025;8(6):e70197. 18. Rodolico V, Di Carlo P, Geraci G, et al. Inflammatory Pseudotumor of the Anal Canal Mimicking Colorectal Cancer: Case Report and Hints to Improve a Patient’s Fitness for Treatment and Prevention. Diagnostics. 2025;15(7):885. 19. Baba SK, Alblooshi SSE, Yaqoob R, et al. Human papilloma virus (HPV) mediated cancers: an insightful update. Journal of Translational Medicine. 2025;23(1):483. 20. Vats A, Trejo-Cerro O, Thomas M, et al. Human papillomavirus E6 and E7: What remains? Tumour virus research. 2021;11:200213. 21. Usman M, Hameed Y, Ahmad M. Does human papillomavirus cause human colorectal cancer? Applying Bradford Hill criteria postulates. Ecancermedicalscience. 2020;14:1107. 22. Fernandes Q, Gupta I, Vranic S, et al. Human papillomaviruses and epstein–barr virus interactions in colorectal cancer: A brief review. Pathogens. 2020;9(4):300. 23. Dust K, Carpenter M, Chen JC-y, et al. Human papillomavirus 16 E6 and E7 oncoproteins alter the abundance of proteins associated with DNA damage response, immune signaling and epidermal differentiation. Viruses. 2022;14(8):1764. 24. Li J, Li S. From Viral Infection to Genome Reshaping: The Triggering Role of HPV Integration in Cervical Cancer. International journal of molecular sciences. 2025;26(18):9214. 25. Labarge B, Hennessy M, Zhang L, et al. Human papillomavirus integration strictly correlates with global genome instability in head and neck cancer. Molecular Cancer Research. 2022;20(9):1420-8. 26. Qiu Q, Li Y, Fan Z, et al. Gene expression analysis of human papillomavirus‐associated colorectal carcinoma. BioMed research international. 2020;2020(1):5201587. 27. Li Q, Geng S, Luo H, et al. Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy. Signal Transduction and Targeted Therapy. 2024;9(1):266. 28. Rad HS, Shiravand Y, Radfar P, et al. Understanding the tumor microenvironment in head and neck squamous cell carcinoma. Clinical & Translational Immunology. 2022;11(6):e1397. 29. Ambrosio MR, Niccolai E, Petrelli F, et al. Immune landscape and oncobiota in HPV-Associated Colorectal Cancer: an explorative study. Clin Exp Med. 2023;23(8):5101-12. 30. Pei B, Liu P, Peng S, et al. Mendelian randomization analyses support causal relationships between HPV infection and colorectal cancer. Discover Oncology. 2024;15(1):795. 31. Pan P-H, Luo C-W, Ting W-C, et al. Impact of ascending HPV infection on colorectal cancer risk: evidence from a nationwide study. Microorganisms. 2024;12(9):1746. 32. Fernandes Q, Gupta I, Murshed K, et al. Coinfection of HPVs is associated with advanced stage in colorectal cancer patients from Qatar. Pathogens. 2023;12(3):424. 33. Zhou J, Liu Y, Zhang Y, et al. Comprehensive analysis of a novel subtype of immune microenvironment-derived HPVinfected colorectal cancer. Microbes and Infection. 2024;26(4):105315. 34. Thangarajah F, Busshoff J, Salamon J, et al. Digital droplet PCR-based quantification of ccfHPV-DNA as liquid biopsy in HPV-driven cervical and vulvar cancer. Journal of Cancer Research and Clinical Oncology. 2023;149(14):12597-604. 35. Galati L, Gupta P, Tufaro A, et al. Evaluation of human papillomavirus DNA in colorectal cancer and adjacent mucosal tissue samples. Infectious Agents and Cancer. 2023;18(1):71. 36. Naegele S, Ruiz-Torres DA, Zhao Y, et al. Comparing the diagnostic performance of quantitative PCR, digital droplet PCR, and nextgeneration sequencing liquid biopsies for human papillomavirus–associated cancers. The Journal of Molecular Diagnostics. 2024;26(3):179-90. 37. Amin FAS, Un Naher Z, Ali PSS. Molecular markers predicting the progression and prognosis of human papillomavirus-induced cervical lesions to cervical cancer. Journal of Cancer Research and Clinical Oncology. 2023;149(10):8077-86. 38. Athanasiou A, Bowden S, Paraskevaidi M, et al. HPV vaccination and cancer prevention. Best Practice & Research Clinical Obstetrics & Gynaecology. 2020;65:109-24. 39. Kamolratanakul S, Pitisuttithum P. Human Papillomavirus Vaccine Efficacy and Effectiveness against Cancer. Vaccines [Internet]. 2021; 9(12):[1413 p.]. 40. Lee MY, Allen CT, editors. Immunotherapy for HPV malignancies. Seminars in radiation oncology; 2021: Elsevier. 41. Mo Y, Ma J, Zhang H, et al. Prophylactic and therapeutic HPV vaccines: current scenario and perspectives. Frontiers in cellular and infection microbiology. 2022;12:909223. 42. Khairkhah N, Bolhassani A, Najafipour R. Current and future direction in treatment of HPV-related cervical disease. Journal of Molecular Medicine. 2022;100(6):829-45. 43. Huang Y, Wang J, Yang W, et al. Precision therapeutic targets for HPV-positive cancers: an overview and new insights. Infectious Agents and Cancer. 2025;20(1):17. | ||
|
آمار تعداد مشاهده مقاله: 279 تعداد دریافت فایل اصل مقاله: 175 |
||