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Dutta, Pranya, Vats, Mansi, Pal, Sayani, Chakraborty, Soumi. (1404). Conventional versus Modified Ketogenic Diets in Autism Spectrum Disorder: Transforming and Shaping Future Approaches. سامانه مدیریت نشریات علمی, 10(4), 546-560. doi: 10.30476/ijns.2025.107079.1482
Pranya Dutta; Mansi Vats; Sayani Pal; Soumi Chakraborty. "Conventional versus Modified Ketogenic Diets in Autism Spectrum Disorder: Transforming and Shaping Future Approaches". سامانه مدیریت نشریات علمی, 10, 4, 1404, 546-560. doi: 10.30476/ijns.2025.107079.1482
Dutta, Pranya, Vats, Mansi, Pal, Sayani, Chakraborty, Soumi. (1404). 'Conventional versus Modified Ketogenic Diets in Autism Spectrum Disorder: Transforming and Shaping Future Approaches', سامانه مدیریت نشریات علمی, 10(4), pp. 546-560. doi: 10.30476/ijns.2025.107079.1482
Dutta, Pranya, Vats, Mansi, Pal, Sayani, Chakraborty, Soumi. Conventional versus Modified Ketogenic Diets in Autism Spectrum Disorder: Transforming and Shaping Future Approaches. سامانه مدیریت نشریات علمی, 1404; 10(4): 546-560. doi: 10.30476/ijns.2025.107079.1482

Conventional versus Modified Ketogenic Diets in Autism Spectrum Disorder: Transforming and Shaping Future Approaches

International Journal of Nutrition Sciences
مقاله 2، دوره 10، شماره 4، اسفند 2025، صفحه 546-560    اصل مقاله (2.37 M)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijns.2025.107079.1482
نویسندگان
Pranya Dutta1؛ Mansi Vats1؛ Sayani Pal* 2؛ Soumi Chakraborty* 1
1Amity Institute of Food Technology, Amity University, Noida, Uttar Pradesh, India
2Department of Food & Nutrition, Brainware University, Barasat campus, Kolkata -700125, India
چکیده
Recently researchers have highlighted the advantages and disadvantages of modified ketogenic diet (MKD) and optimum use of this dietary intervention for providing personalised nutrition in individuals having Autism Spectrum Disorder (ASD). This study aimed to provide a comprehensive review and analysis of the effects of the Ketogenic Diet (KD) and its MKD on individuals with ASD. The KD is a highfat, low-carbohydrate dietary regimen that mimics the metabolic state of fasting by triggering ketosis, a process where the body shifts from
using carbohydrates to fats as its primary energy source. The MKD, a more flexible adaptation of the traditional KD, permits a slightly higher intake of protein and carbohydrates; while still sustaining ketosis. Both diets have shown potential in influencing key factors associated with ASD, including neurotransmitter activity, gut microbiome composition, cognitive function, behavior, and overall quality of life. This review delves into the mechanisms by which KD and MKD may benefit individuals with ASD, drawing insights from both animal models and human case studies. Additionally, it explores the therapeutic potential and limitations of these dietary strategies, particularly in addressing co-occurring conditions frequently observed in those with ASD. Through this analysis, the study seeks to shed light on the promise of nutritional interventions (carbohydrate modification, addition of probiotics, omega 3 fatty acids and selenium) in the broader management of autism-related challenges.

تازه های تحقیق

Pranaya Dutta (Google Scholar)

Sayani Pal (Google Scholar)

Soumi Chakraborty (Google Scholar)

کلیدواژه‌ها
Autism spectrum disorder؛ Ketogenic diet؛ Modified ketogenic diet؛ Cognitive behaviour؛ Gut health
مراجع
  1. Harm M, Hope M, Household A. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th edn, Washington, DC: American Psychiatric Association; 2013.
  2. Lord C, Elsabbagh M, Baird G, et al. Autism spectrum disorder. Lancet. 2018;392:508-520. DOI: 10.1016/S0140-6736(18)31129-2. PMID: 30078460.
  3. Önal S, Sachadyn-Król M, Kostecka M. A review of the nutritional approach and the role of dietary components in children with autism spectrum disorders in light of the latest scientific research. Nutrients. 2023;15:4852. DOI: 10.3390/nu15234852. PMID: 38068711.
  4. Shilpa J, Mohan V. Ketogenic diets: Boon or bane? Indian J Med Res. 2018;148(3), pp.251-253. DOI: 10.4103/ijmr.IJMR_1666_18. PMID: 30425213.
  5. Hedayati A, Homayuon M, Mobaracky A, et al. Lithium Chloride, Ketogenic Diet and Stem Cell Transplantation in Treatment of Bipolar Disorder. Int J Nutr Sci. 2024;9:80-82. DOI: 10.30476/IJNS.2024.99601.1250.
  6. Kossoff EH,  Zupec‐Kania BA, Auvin S, et al. Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group. Epilepsia Open. 2018;3:175-192. DOI: 10.1002/epi4.12225. PMID: 29881797.
  7. Masood W, Annamaraju P, Suheb MZK, et al. Ketogenic diet. In StatPearl. https://www.ncbi.nlm.nih.gov/books/NBK499830. Acessed May 9, 2025.
  8. Kossoff EH, Hartman AL. Ketogenic diets: new advances for metabolism-based therapies. Curr Opin Neurol. 2012;25:173-178. DOI: 10.1097/WCO.0b013e3283515e4a. PMID: 22322415.
  9. Sohrabi Z, Eftekhari MH, Akbarzadeh M. Effect of Protein Supplementation on SerumElectrolytes in Hemodialysis Patients. Int J Nutr Sci. 2019;4:30-35. DOI: 10.30476/IJNS.2019.81532.1008.
  10. Pérez-Cabral ID, Bernal-Mercado AT, Islas-Rubio AR, et al. Exploring Dietary Interventions in Autism Spectrum Disorder. Foods. 2024;13:3010. DOI: 10.3390/foods13183010. PMID: 39335937.
  11. Ruskin DN, Svedova J, Cote, JL, et al. Ketogenic diet improves core symptoms of autism in BTBR mice. PLoS One. 2013;8:e65021. DOI: 10.1371/journal.pone.0065021. PMID: 23755170.
  12. Courchesne E, Gazestani VH, Lewis NE. Prenatal origins of ASD: the when, what, and how of ASD development. Trends Neurosci. 2020;43:326-342. DOI: 10.1016/j.tins.2020.03.005. PMID: 32353336.
  13. Paoli A, Rubini A, Volek JS, et al. Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. Eur J Clin Nutr. 2013;67:789-796. DOI: 10.1038/ejcn.2013.116. PMID: 23801097.
  14. Roehl K, Sewak SL. Practice paper of the academy of nutrition and dietetics: classic and modified ketogenic diets for treatment of epilepsy. J Acad Nutr Diet.  2017;117:1279-1292. DOI: 10.1016/j.jand.2017.06.006. PMID: 28754198.
  15. Banerjee S. A Review of the Effectiveness of Various Diet types on Autism. J Ment Health Sys. 2023;2799-1261. DOI: 10.55529/jmhib.31.1.7.
  16. D’Andrea Meira I, Romão TT, Pires do Prado HJ, et al. Ketogenic diet and epilepsy: what we know so far. Front. Neurosci. 2019;13:5.
  17. Kossoff E.H, Zupec‐Kania B.A, Amark P.E, et al. Optimal clinical management of children receiving the ketogenic diet: recommendations of the International Ketogenic Diet Study Group. Epilepsia. 2009;50:304-317. DOI: 10.1111/j.1528-1167.2008.01765.x. PMID: 18823325.
  18. Varesio C, Grumi S, Zanaboni MP, et al. Ketogenic dietary therapies in patients with autism spectrum disorder: facts or fads? A scoping review and a proposal for a shared protocol. Nutrients. 2021;13:2057. DOI: 10.3390/nu13062057. PMID: 34208488.
  19. Neal EG, Chaffe H, Schwartz RH, et al. The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. The Lancet Neurology. 2008;7:500-506. DOI: 10.1016/S1474-4422(08)70092-9. PMID: 18456557.
  20. DeCampo DM, Kossoff EH. Ketogenic dietary therapies for epilepsy and beyond. Curr Opin Clin Nutr Metab Care. 2019; 22:264-268. DOI: 10.55529/jmhib.31.1.7.
  21. Lee RW, Corley MJ, Pang A, et al. A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder. Physiol Behav. 2018;188:205-211.
  22. Masino SA, Rho JM. Mechanisms of ketogenic diet action. Jasper's Basic Mechanisms of the Epilepsies. 4th edition. https://www.ncbi.nlm.nih.gov/books/NBK98219/. Accessed  May 9, 2025.
  23. Mazandarani M, Lashkarbolouk N, Ejtahed HS, et al. Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review. J Nutr. 2023;22:61. DOI: 10.1186/s12937-023-00893-2. PMID: 37981693.
  24. Li Q, Liang J, Fu N, et al. A ketogenic diet and the treatment of autism spectrum disorder. Front. Pediatr. 2021;9:5. DOI: 10.3389/fped.2021.650624. PMID: 34046374.
  25. Coghlan S, Horder J, Inkster B, et al. GABA system dysfunction in autism and related disorders: from synapse to symptoms. Neurosci Biobehav Rev. 2012;36:2044-2055. DOI: 10.1016/j.neubiorev.2012.07.005. PMID: 22841562.
  26. Mishra P, Singh SC, Ram B. Drug resistant epilepsy and ketogenic diet: A narrative review of mechanisms of action. World Neurosurg X. 2024;22:100328. DOI:10.1016/j.wnsx.2024.100328. PMID: 38444870.
  27. Montanari M, Martella G, Bonsi P, et al. Autism Spectrum Disorder: Focus on Glutamatergic Neurotransmission. Int J Mol Sci. 2022;23:3861. DOI: 10.3390/ijms23073861. PMID: 35409220.
  28. Gano LB, Patel M, Rho JM. Ketogenic diets, mitochondria, and neurological diseases. J Lipid Res. 2014;55:2211-2228.  DOI: 10.1194/jlr.R048975. PMID: 24847102.
  29. Muller CL, Anacker AMJ, Veenstra-VanderWeele J. The serotonin system in autism spectrum disorder: From biomarker to animal models. Neuroscience. 2016;321:24-41. DOI: 10.1016/j.neuroscience.2015.11.010. PMID: 26577932.
  30. Jang J, Kim SR, Lee JE, et al. Molecular mechanisms of neuroprotection by ketone bodies and ketogenic diet in cerebral ischemia and neurodegenerative diseases. Int J Mol Sci.  2024;25:124. DOI: 10.3390/ijms25010124. PMID: 38203294.
  31. Edjtehadi M, Mehrabani D. Prevention Of Epinephrine-Induced Arrythmias With Lidocaine During Thiopental And Methoxyflurane Anesthesia In Sheep. J Appl Anim Res. 2005;27:55-59.
  32. Edjtehadi M, Mehrabani D. Response To Epinephrine On Electrocardiogram During Thiopental And Methoxyflurane Anesthesia In Sheep. J Appl Anim Res. 2003;24:89-94.
  33. Ghallab YK, Elassal OS. Biochemical and neuropharmacology of psychiatric disorders. In: Nutrition and Psychiatric Disorders: An Evidence-Based Approach to Understanding the Diet-Brain Connection. Singapore: Springer Nature Singapore. 2024;25-47.
  34. Dyńka D, Kowalcze K, Paziewska A. The role of ketogenic diet in the treatment of neurological diseases. Nutrients. 2022;14:5003. DOI: 10.3390/nu14235003. PMID: 36501033.
  35. Makris G, Agorastos A, Chrousos GP, et al. Stress system activation in children and adolescents with autism spectrum disorder. Front Neurosci. 2022;15:756628. DOI: 10.3389/fnins.2021.756628. PMID: 35095389.
  36. Teleanu RI, Niculescu AG, Roza E, et al. Neurotransmitters: Key factors in neurological and neurodegenerative disorders of the central nervous system. Int J Mol Sci. 2022;23:5955. DOI: 10.3390/ijms23115954. PMID: 35682631.
  37. Pietrzak D, Kasperek K, Rękawek P, et al. The therapeutic role of ketogenic diet in neurological disorders. Nutrients. 2022;14:1952. DOI: 10.3390/nu14091952. PMID: 35565918.
  38. Murano C, Binda A, Palestini P, et al. Effect of the ketogenic diet in excitable tissues. Am J Physiol Cell Physiol. 2021;320:C547-C553. DOI: 10.1152/ajpcell.00458.2020. PMID: 33502948.
  39. Goswami TK, Singh M, Dhawan M, et al. Regulatory T cells (Tregs) and their therapeutic potential against autoimmune disorders – Advances and challenges. Hum Vaccin Immunother. 2022;18:2035117. DOI: 10.1080/21645515.2022.2035117. PMID: 35240914.
  40. Zhao H, Mao X, Zhu C, et al. GABAergic system dysfunction in autism spectrum disorders. Front Cell Dev Biol. 2022;9:781327. DOI: 10.3389/fcell.2021.781327. PMID: 35198562.
  41. Srivastava S,  Pawar  VA,  Tyagi  A, et al. Immune modulatory effects of ketogenic diet in different disease conditions. Immuno. 2023;3:1-15. DOI:10.3390/immuno3010001
  42. Bough KJ, Rho JM. Anticonvulsant mechanisms of the ketogenic diet. Epilepsia. 2007;48:43-58. DOI: 10.1111/j.1528-1167.2007.00915.x. PMID: 17241207
  43. Robinson-Agramonte MdLA, García EN, Guerra  JF, et al. Immune dysregulation in autism spectrum disorder: What do we know about it?  Int J Mol Sci. 2022;23:3033. DOI: 10.3390/ijms23063033. PMID: 35328471
  44. Shang H, Shen X, Yu X, et al. B-cell targeted therapies in autoimmune encephalitis: Mechanisms, clinical applications, and therapeutic potential. Front Immunol. 2024;15:1368275. DOI: 10.3389/fimmu.2024.1368275. PMID: 38562943
  45. Mehrabani D, Masoumi SJ, Masoumi AS, et al. Role of Diet in Mesenchymal Stem Cells’ Function: A Review. Int J Nutr Sci. 2023;8:9-19. DOI: 10.30476/IJNS.2023.97788.1221.
  46. Olivito I, Avolio E, Minervini D, et al. Ketogenic diet ameliorates autism spectrum disorders-like behaviors via reduced inflammatory factors and microbiota remodeling in BTBR T+ Itpr3tf/J mice. Exp Neurol. 2023;366:114432. DOI: 10.1016/j.expneurol.2023.114432. PMID: 37149279.
  47. Lampiasi N, Bonaventura R, Deidda I, et al. Inflammation and the potential implication of macrophage-microglia polarization in human ASD: An overview. Int J Mol Sci.  2023;24:2703. DOI: 10.3390/ijms24032703. PMID: 36769026.
  48. Khamoushi A, Aalipanah E, Sohrabi Z, et al. Vitamin D and Autism Spectrum Disorder: A Review. Int J Nutr Sci. 2019;4:9-13. DOI: 10.30476/IJNS.2019.81436.1004.
  49. Kim D.Y, Davis L.M, Sullivan P.G, et al. Ketogenic diet modulates mitochondrial respiratory chain complexes and increases fatty acid oxidation in epileptic rats. J Lipid Res. 2014; 51:2325-2332. DOI: 10.1177/0271678X15610584.
  50. Pinto A, Bonucci A, Maggi E, et al. Anti-oxidant and anti-inflammatory activity of ketogenic diet: New perspectives for neuroprotection in Alzheimer's disease. Antioxidants (Basel). 2018;7:63. DOI: 10.3390/antiox7050063. PMID: 29710809.
  51. Poff AM, Moss S, Soliven M, et al. Ketone supplementation: Meeting the needs of the brain in an energy crisis. Front Nutr. 2021;8:783659. DOI: 10.3389/fnut.2021.783659. PMID: 35004814.
  52. Ruskin DN, Svedova J, Cote JL, et al. Ketogenic diet improves core symptoms of autism in BTBR mice. PLoS One. 2013;8:e65021. DOI: 10.1371/journal.pone.0065021. PMID: 23755170.
  53. Bjorklund G, Saad K, Chirumbolo S, et al. Immune dysfunction and neuroinflammation in autism spectrum disorder. Acta Neurobiol. Exp. (Wars). 2016;  76:257-268. DOI: 10.21307/ane-2017-025. PMID: 28094817.
  54. Rawat K, Singh N, Kumari P, et al. A review on preventive role of ketogenic diet (KD) in CNS disorders from the gut microbiota perspective. Rev Neurosci. 2021;32:143-57. DOI: 10.1515/revneuro-2020-0078. PMID: 33070123.
  55. Xie G, Zhou Q, Qiu CZ, et al. Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy. World J Gastroentero.  2017;23:6164-6171. DOI: 10.3748/wjg.v23.i33.6164. PMID: 28970732.
  56. Olson CA, Vuong HE, Yano JM, et al. The gut microbiota mediates the anti-seizure effects of the ketogenic diet. Cell. 2018;173:1728-1741. DOI: 10.1016/j.cell.2018.06.051. PMID: 30007420.
  57. Paoli A, Mancin L, Bianco  A, et al. Ketogenic diet and microbiota: friends or enemies? Genes (Basel). 2019;10:534. DOI: 10.3390/genes10070534. PMID: 31311141.
  58. Imdad K, Abualait T, Kanwal A, et al. The metabolic role of ketogenic diets in treating epilepsy. Nutrients. 2022;14:5074.   DOI: 10.3390/nu14235074. PMID: 36501104.
  59. Newell C, Bomhof MR, Reimer RA, et al. Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder. Molecular Autism. 2016;7:1-6. DOI: 10.1186/s13229-016-0099-3. PMID: 27594980.
  60. Santangelo A, Corsello A, Spolidoro GCI, et al. The influence of ketogenic diet on gut microbiota: potential benefits, risks and indications. Nutrients. 2023;15:3680. DOI: 10.3390/nu15173680. PMID: 37686712.
  61. Reznik E. A review of a ketogenic diet in the treatment of autism spectrum disorder . Loma Linda University Electronic Theses, Dissertations & Projects. 2024;43. https://scholarsrepository.llu.edu/etd/1713.
  62. Taniya MA, Chung HJ, Mamun AA, et al. Role of gut microbiome in autism spectrum disorder and its therapeutic regulation. Front. Cell Infect Microbiol. 2022;12:915701. DOI: 10.3389/fcimb.2022.915701. PMID: 35937689.
  63. Lim JM, Letchumanan V, Tan LTH, et al. Ketogenic diet: a dietary intervention via gut microbiome modulation for the treatment of neurological and nutritional disorders (a narrative review). Nutrients. 2022;14:3566. DOI: 10.3390/nu14173566. PMID: 36079829.
  64. Strandwitz P. Neurotransmitter modulation by the gut microbiota. Brain Res. 2018;1693:128-133. DOI: 10.1016/j.brainres.2018.03.015. PMID: 29903615.
  65. Herbert MR, Buckley JA. Autism and dietary therapy: case report and review of the literature. J Child Neurol. 2013;28:975-982. DOI: 10.1177/0883073813488668. PMID: 23666039.
  66. Barthold M,  Jurkutat A,  Goetz  R, et al. Timing of ketogenic dietary therapy (KDT) introduction and its impact on cognitive profiles in children with Glut1-DS—A preliminary study. Epilepsia. 2023;10:681. DOI: 10.3390/children10040681. PMID: 37189930.
  67. Chinna-Meyyappan A, Gomes FA, Koning E, et al. Effects of the ketogenic diet on cognition: a systematic review. Nutr Neurosci. 2022;26:1258-1277. DOI: 10.1080/1028415X.2022.2143609. PMID: 36354157.
  68. Hosseini-Asl SMK, Mehrabani G, Masoumi SJ. Key Focus Areas in Pouchitis Therapeutic Status: A Narrative Review. Iran J Med Sci. 2024;49:472-486. DOI: 10.30476/ijms.2024.100782.3326. PMID: 39205822.
  69. Masoumi SJ, Mehrabani D, Saberifiroozi M, et al. The effect of yogurt fortified with Lactobacillus acidophilus and Bifidobacterium sp. probiotic in patients with lactose intolerance. Food Sci Nutr. 2021;9:1704-1711. DOI: 10.1002/fsn3.2145. PMID: 33747481.
  70. Ruskin DN, Svedova J, Cote JL, et al. Ketogenic diet improves core symptoms of autism in BTBR mice. PLoS One. 2013;8:e65021. DOI: 10.1371/journal.pone.0065021. PMID: 23755170.
  71. Chauhan A, Audhya T, Chauhan, V. Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin—the antioxidant proteins. Life Sci. 2015;75:2539-2549. DOI: 10.1016/j.lfs.2004.04.038. PMID: 15363659.
  72. Greco T, Glenn TC, Hovda DA, et al. Ketogenic diet decreases oxidative stress and improves mitochondrial respiratory complex activity. J Cereb Blood Flow Metab. 2016;36:1603-1613. DOI: 10.1177/0271678X15610584. PMID: 26661201.
  73. Pérez-Cabral ID, Bernal-Mercado AT, Islas-Rubio AR, et al. Exploring dietary interventions in autism spectrum disorder. Foods. 2024;13:3010. DOI: 10.3390/foods13183010. PMID: 39335937.
  74. Siddiqui M.F, Elwell C, Johnson M.H. Mitochondrial dysfunction in autism spectrum disorders. Autism Open Access. 2016;6:1000190. DOI: 10.4172/2165-7890.1000190. PMID: 27928515.
  75. Masino SA, Li T, Theofilas P, et al. A ketogenic diet suppresses seizures in mice through adenosine A₁ receptors. J Clin Invest. 2011;121:2679-2683. DOI: 10.1172/JCI57813. PMID: 21701065.
  76. Napoli E, Dueñas N, Giulivi C. Potential therapeutic use of the ketogenic diet in autism spectrum disorders. Front Pediatr. 2014;2:69. DOI: 10.3389/fped.2014.00069. PMID: 25072037.
  77. Albers J, Kraja G, Eller D, et al. Assessing the feasibility of using the ketogenic diet in autism spectrum disorder. J Hum Nutr Diet. 2022;36:1303-1315. DOI: 10.1111/jhn.13115.
  78. Hallböök T,  Ji  S, Maudsley S, et al. The effects of the ketogenic diet on behavior and cognition. Epilepsy Res. 2012;100:304-309. DOI: 10.1016/j.eplepsyres.2011.04.017. PMID: 21872440.
  79. Sanie-Jahromi F, Nowroozzadeh MH, Shaabanian M, et al. Characterization of Central and Nasal Orbital Adipose Stem Cells and their Neural Differentiation Footprints. Curr Stem Cell Res Ther. 2024;19:1111-1119. DOI: 10.2174/1574888X19666230905114246. PMID: 37670706.
  80. Gogou M,  Kolios G. Are therapeutic diets an emerging additional choice in autism spectrum disorder management? World J Pediatr. 2018;14:215-223. DOI: 10.1007/s12519-018-0164-4. PMID: 29846886.
  81. Möhrle D, Murari K, Rho JM, et al. Improving vocal communication with a ketogenic diet in a mouse model of autism. bioRxiv. 2023;2023-10. DOI: 10.1101/2023.10.05.561083.
  82. Marie-Ève  T, Verkhratsky A. Microglia: Physiology, Pathophysiology and Therapeutic Potential. Springer International Publishing : Imprint: Springer, 2024;37.p.457.
  83.  Barthold M, Jurkutat A, Goetz R, et al. Timing of ketogenic dietary therapy (KDT) introduction and its impact on cognitive profiles in children with Glut1-DS—A preliminary study. Epilepsia. 2023;10:681. DOI: 10.3390/children10040681. PMID:37189930.
  84. Kazdoba TM, Leach PT, Yang M, et al. Translational mouse models of autism: advancing toward pharmacological therapeutics. Curr Behav Neurosci Rep. 2016;28:1-52. DOI: 10.1007/7854_2015_5003. PMID: 27305922.
  85. Wang C, Zhang, W. Can the ketogenic diet improve autism spectrum disorder? From perspectives on diversity interventions and treatment. J Educ Humanit Soc Sci. 2023;22:155-161. DOI: 10.54097/ehss.v22i.12413.
  86. Nobili L, Beniczky S, Eriksson SH, et al. Expert opinion: managing sleep disturbances in people with epilepsy. Epilepsy Behav. 2021;124:108341. DOI: 10.1016/j.yebeh.2021.108341. PMID: 34619543.
  87. Pasca L, Quaranta CA, Grumi S, et al. The effects of ketogenic dietary therapies on sleep: a scoping review. J Sleep Res. 2023;33:e13902. DOI: 10.1111/jsr.14073. PMID: 37932966.
  88. Anari L, Mehrabani D, Nasiri M, et al. in Vitro Effect of Methamphetamine on Proliferation, Differentiation and Apoptosis of Adipose Tissue Stem Cells. J Pharm Pharm Sci. 2022;25:69-76. DOI: 10.18433/jpps31843. PMID: 35030074.
  89. Lee RWY, Corley MJ, Pang A, et al. A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder. Physiol Behav. 2018;188:205-211. DOI: 10.1016/j.physbeh.2018.02.006. PMID: 29421589.
  90. McDonald TJ, Cervenka MC. The expanding role of ketogenic diets in adult neurological disorders. Brain Sci. 2018;8:148. DOI: 10.3390/brainsci8080148. PMID: 30096755.
  91. Coppola G, Verrotti A, Ammendola E, et al. Ketogenic diet for the treatment of catastrophic epileptic encephalopathies in childhood. Eur J Paediatr Neurol. 2010;14:229-234. DOI: 10.1016/j.ejpn.2009.06.006. PMID: 19632870.
  92. El-Rashidy O, El-Baz F, El-Gendy Y, et al. Ketogenic diet versus gluten-free casein-free diet in autistic children: a case-control study. Metab. Brain Dis. 2017;32:1935–1941. DOI: 10.1007/s11011-017-0088-z. PMID: 28808808.
  93. Rogovik AL, Goldman RD. Ketogenic diet for treatment of epilepsy. Can Fam Physician. 2010;56:540-542. PMID: 20547519.
  94. Amadi CN, Orish CN, Frazzoli C, et al. Dietary interventions for autism spectrum disorder: An updated systematic review of human studies. Psychiatriki. 2022;33:228-242. DOI: 10.22365/jpsych.2022.073. PMID: 35477082.
  95. Kossoff EH, Hartman AL. Ketogenic diets: New advances for metabolism-based therapies. Curr Opin Neurol. 2012;25:173-178. DOI:10.1097/WCO.0b013e3283515e4a. PMID: 22322415.
  96. Suskind DL, Wahbeh G, Gregory N, et al. Nutritional therapy in pediatric Crohn disease: The specific carbohydrate diet. J Pediatr Gastroenterol Nutr. 2014;58:87-91. DOI: 10.1097/MPG.0000000000000103. PMID: 24048168.
  97. Obih C, Wahbeh G, Lee D, et al. Specific carbohydrate diet for pediatric inflammatory bowel disease in clinical practice within an academic IBD center. Nutrition. 2016;32:418-425. DOI: 10.1016/j.nut.2015.08.025. PMID: 26655069.
  98. Barnhill K, Devlin M, Moreno HT, et al. Brief report: Implementation of a specific carbohydrate diet for a child with autism spectrum disorder and fragile X Syndrome. J Autism Dev Disord. 2020;50:1800-1808. DOI: 10.1007/s10803-018-3704-9. PMID: 30076499.
  99. Grimaldi R, Gibson GR, Vulevic J, et al. A prebiotic intervention study in children with autism spectrum disorders (ASDs). Microbiome. 2018;6:133. DOI: 10.1186/s40168-018-0523-3. PMID: 30071894.
  100. Nolan SO, Hodges SL, Okoh JT, et al. Prenatal high-fat diet rescues communication deficits in Fmr1 mutant mice in a sex-specific manner. Dev Neurosci. 2020;42:94-104. DOI: 10.1159/000509797. PMID: 33395685.
  101. Schiavi S, Carbone E, Melancia F, et al. Perinatal supplementation with omega-3 fatty acids corrects the aberrant social and cognitive traits observed in a genetic model of autism based on FMR1 deletion in rats. Nutri Neurosci. 2022;25:898-911. DOI: 10.1080/1028415X.2020.1819107. PMID: 32912100.
  102. Vats M, Dutta P, Maiti S, et al. Omega 3 Fatty Acid-Rich Nutraceuticals: Current Trends and Future Perspective of Managing Autism Spectrum Disorder. Int J Innov Res Sci. 2024;2:40-53.
  103. Pietropaolo S, Goubran MG, Joffre C, et al. Dietary supplementation of omega-3 fatty acids rescues fragile X phenotypes in Fmr1-Ko mice. Psychoneuroendocrinology.  2014; 49, pp.119–129. DOI: 10.1016/j.psyneuen.2014.07.002. PMID: 25080404.
  104. Leboucher A,  Pisani DF, Martinez-Gili L, et al. The translational regulator FMRP controls lipid and glucose metabolism in mice and humans. Mol Metab. 2019;21:22-35. DOI: 10.1016/j.molmet.2019.01.002. PMID: 30686771.
  105. Bagheri MH, Nazhvani SD, Nikahval B, et al. Articular cartilage changes in experimental osteoarthritis in rabbits: MRI and morphological findings. Comp Clini Pathol. 2011;20:25-31. DOI: 10.1007/s00580-009-0951-3.
  106. Mu C, Corley MJ, Lee RW, et al. Metabolic framework for the improvement of autism spectrum disorders by a modified ketogenic diet: A pilot study. J Proteome Res. 2019;19:382-390.  DOI: 10.1021/acs.jproteome.9b00581. PMID: 31696714.
  107. Stafstrom CE, Rho JM. The ketogenic diet as a treatment paradigm for diverse neurological disorders. Front Pharmacol. 2012;3:59. DOI:10.3389/fphar.2012.00059. PMID: 22509165.
  108. Martin K, Jackson CF, Levy RG, et al. Ketogenic diet and other dietary treatments for epilepsy. Cochrane Database Syst Rev. 2016;2016:CD001903. DOI: 10.1002/14651858.CD001903.pub5. PMID: 32588435.
  109. Ferraris C, Meroni E, Casiraghi MC, et al. One month of classic therapeutic ketogenic diet decreases short-chain fatty acids production in epileptic patients. Front Nutr.  2021;8:613100. DOI: 10.3389/fnut.2021.613100. PMID: 33855040.
  110. Sathe N, Andrews JC, McPheeters ML, et al. Nutritional and dietary interventions for autism spectrum disorder: A systematic review. Pediatrics. 2017;139:e20170346. DOI: 10.1542/peds.2017-0346. PMID: 28562286.
  111. Azad A, Ranjbaran A, Zareshahrabadi Z, et al. Protective Effects of the Probiotic Bacterium Streptococcus thermophilus on Candida albicans Morphogenesis and a Murine Model of Oral Candidiasis. Iran J Med Sci. 2021;46:207-217. DOI: 10.30476/ijms.2020.82080.0. PMID: 34083853.
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