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Advances in Understanding Immune Dysregulation and Therapeutic Strategies Targeting Epidermal and Dermal Cells in Keloids | ||
| Iranian Journal of Immunology | ||
| دوره 22، شماره 4، اسفند 2025 اصل مقاله (1.43 M) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2025.107262.3048 | ||
| نویسندگان | ||
| Yuan Xia؛ Jing Niu؛ Hengheng Fan؛ Lin Liu؛ Yuan Zhou؛ Yuyun Xiong؛ Yumei Li* | ||
| Department of Dermatology, Institute of Regenerative Medicine, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang 212001, China. | ||
| چکیده | ||
| Keloid, as a skin fibrotic proliferative disorder, have a complex pathogenesis that remains incompletely understood. It is characterized by abnormal and excessive scar formation following skin injury. The occurrence and development of keloids are closely associated with immune dysregulation. Immune cells, such as T cells, macrophages, mast cells, and Langerhans cells, play crucial roles in the formation of keloids. These immune cells contribute to keloid initiation and progression through mechanisms including cytokine secretion, promotion of inflammatory responses, and regulation of fibroblast proliferation and collagen synthesis. With advances in immunological research, the roles of fibroblasts, keratinocytes and melanocytes in the immunological dysregulation underlying keloids have received increasing attention. This paper aims to review recent progress on the abnormal immunological regulation involving these three epidermal cell types, in order to provide new insights and theoretical foundations for the treatment of this disease. | ||
| کلیدواژهها | ||
| Fibroblast؛ Hypertrophic scar؛ Immunological regulation؛ Keratinocyte؛ Melanocyte | ||
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آمار تعداد مشاهده مقاله: 7 تعداد دریافت فایل اصل مقاله: 3 |
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