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Divband, Baharak, Al-Yasiri, Amal Y., Mohammed Saeed, Najwan, Khezerloo, Davood, Gharehaghaji, Nahideh. (1404). Magnetic Resonance Imaging, Fluorescence, and Drug Release Properties of Curcumin-Loaded PEGylated Magnetite@Graphene Quantum Dots Nanocomposite. سامانه مدیریت نشریات علمی, (), -.
Baharak Divband; Amal Y. Al-Yasiri; Najwan Mohammed Saeed; Davood Khezerloo; Nahideh Gharehaghaji. "Magnetic Resonance Imaging, Fluorescence, and Drug Release Properties of Curcumin-Loaded PEGylated Magnetite@Graphene Quantum Dots Nanocomposite". سامانه مدیریت نشریات علمی, , , 1404, -.
Divband, Baharak, Al-Yasiri, Amal Y., Mohammed Saeed, Najwan, Khezerloo, Davood, Gharehaghaji, Nahideh. (1404). 'Magnetic Resonance Imaging, Fluorescence, and Drug Release Properties of Curcumin-Loaded PEGylated Magnetite@Graphene Quantum Dots Nanocomposite', سامانه مدیریت نشریات علمی, (), pp. -.
Divband, Baharak, Al-Yasiri, Amal Y., Mohammed Saeed, Najwan, Khezerloo, Davood, Gharehaghaji, Nahideh. Magnetic Resonance Imaging, Fluorescence, and Drug Release Properties of Curcumin-Loaded PEGylated Magnetite@Graphene Quantum Dots Nanocomposite. سامانه مدیریت نشریات علمی, 1404; (): -.

Magnetic Resonance Imaging, Fluorescence, and Drug Release Properties of Curcumin-Loaded PEGylated Magnetite@Graphene Quantum Dots Nanocomposite

Journal of Biomedical Physics and Engineering
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 28 آبان 1404
نوع مقاله: Original Research
نویسندگان
Baharak Divband1، 2، 3؛ Amal Y. Al-Yasiri4؛ Najwan Mohammed Saeed4؛ Davood Khezerloo1، 5؛ Nahideh Gharehaghaji* 1، 5
1Medical Radiation Sciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3Inorganic Chemistry Department, Chemistry Faculty, University of Tabriz, Tabriz, Iran
4Department of Basic Sciences, College of Dentistry, University of Baghdad, Baghdad, Iraq
5Department of Radiology, Faculty of Allied Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده
Background: Multifunctional nanosystems, containing medical imaging components and cancer therapeutic drugs, can provide early cancer diagnosis and treatment.
Objective: The aim of this study was to investigate Magnetic Resonance Imaging (MRI), anticancer drug delivery, and fluorescence properties of curcumin-loaded PEGylated magnetite@graphene quantum dots nanocomposite.
Material and Methods: In this experimental study, PEGylated magnetite@graphene quantum dots (Fe3O4@GQDs-PEG) nanocomposite was synthesized and loaded with curcumin (CUR-Fe3O4@GQDs-PEG). Then, the size, shape, magnetic property, MRI r2 relaxivity, drug loading and in vitro release, and fluorescence property of the nanocomposite were investigated. Evaluation of the cell toxicity against MCF-7 cells was performed for both unloaded and curcumin-loaded nanocomposites.
Results: The superparamagnetic nanocomposite showed high r2 relaxivity, drug release, and fluorescence property. The curcumin-loaded nanocomposite was significantly toxic to the breast cancer cell line at high concentrations.  
Conclusion: CUR-Fe3O4@GQDs-PEG nanocomposite can be considered an anticancer drug carrier and an appropriate potential candidate for dual modal MRI and fluorescence imaging.
کلیدواژه‌ها
Magnetite؛ Curcumin؛ Nanocomposite؛ Drug Release؛ Magnetic Resonance Imaging؛ Fluorescence
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تعداد مشاهده مقاله: 2


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