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Ghaderi, Hamid, Fattahi, Mohammad Javad, Shirmardi Dezaki, Hossain, Malekzadeh, Mahyar, Khademi, Bijan, Ghaderi, Abbas, Haghshenas, Mohammad Reza. (1404). Interleukin-37 Serum Levels in Oral Squamous Cell Carcinoma. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/dentjods.2025.105421.2595
Hamid Ghaderi; Mohammad Javad Fattahi; Hossain Shirmardi Dezaki; Mahyar Malekzadeh; Bijan Khademi; Abbas Ghaderi; Mohammad Reza Haghshenas. "Interleukin-37 Serum Levels in Oral Squamous Cell Carcinoma". سامانه مدیریت نشریات علمی, , , 1404, -. doi: 10.30476/dentjods.2025.105421.2595
Ghaderi, Hamid, Fattahi, Mohammad Javad, Shirmardi Dezaki, Hossain, Malekzadeh, Mahyar, Khademi, Bijan, Ghaderi, Abbas, Haghshenas, Mohammad Reza. (1404). 'Interleukin-37 Serum Levels in Oral Squamous Cell Carcinoma', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/dentjods.2025.105421.2595
Ghaderi, Hamid, Fattahi, Mohammad Javad, Shirmardi Dezaki, Hossain, Malekzadeh, Mahyar, Khademi, Bijan, Ghaderi, Abbas, Haghshenas, Mohammad Reza. Interleukin-37 Serum Levels in Oral Squamous Cell Carcinoma. سامانه مدیریت نشریات علمی, 1404; (): -. doi: 10.30476/dentjods.2025.105421.2595

Interleukin-37 Serum Levels in Oral Squamous Cell Carcinoma

Journal of Dentistry
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 27 آبان 1404    اصل مقاله (358.74 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/dentjods.2025.105421.2595
نویسندگان
Hamid Ghaderi1؛ Mohammad Javad Fattahi2؛ Hossain Shirmardi Dezaki2؛ Mahyar Malekzadeh2؛ Bijan Khademi3؛ Abbas Ghaderi2؛ Mohammad Reza Haghshenas* 2
1Violet Vines Marshman Centre for Rural Health Research, La Trobe University, Bendigo, Australia.
2Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
3Otolaryngology Research Center, Dept. of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
Background: Squamous cell carcinoma (SCC) is the most common cancer of the maxillofacial area, known for its high mortality and morbidity rates. Increasing evidence highlights the critical role of chronic inflammation in human malignancies by modulating inflammatory cells and cytokine synthesis. IL-37 is recognized as a cytokine that may play a dual role in cancer.
Purpose: This study sought to investigate IL-37 serum concentrations in individuals with oral SCC, specifically SCC of the tongue.
Materials and Method: This case-control study investigated IL-37 serum levels and their association with the patients' clinicopathological characteristics in 65 cases of oral SCC compared to 65 healthy controls using the ELISA technique. The study further assessed the diagnostic significance of IL-37 serum concentrations using receiver operating characteristic (ROC) curve analysis.
Results: The results indicated that IL-37 serum concentrations were markedly higher in patients than in the control group, although no association with the patients' clinicopathological characteristics was found. The best cut-off point for the serum IL-37 level was 61.95 pg/ml, with a sensitivity of 92.30% and specificity of 87.70%. The ROC curve area was 0.90.
Conclusion: The significant increase of serum IL-37 levels in oral SCC patients underscores its involvement in the disease's pathology and suggests its potential use in early detection and screening. Future studies should aim to elucidate the interplay of this cytokine with the tumor microenvironment (TME) and explore its possible diagnostic and therapeutic applications in cancer.
کلیدواژه‌ها
Oral Squamous Cell Carcinoma؛ Interleukin 37 Protein؛ Enzyme-Linked Immunosorbent Assay
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