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Stephenson, George, Pandyan, Deepak, Chandran, Satheesh, Narasimman, Deenadayalan, Premkumar, Karthik, Rajendran, Balamurugan, Pethuraj, Vijayalakshmi. (1404). Efficacy of Leukocyte Platelet Rich Fibrin (L-PRF) Versus L-PRF with βeta Tri-calcium Phosphate (β-TCP) Bone Graft in Mandibular Impacted Third Molar Surgery: A Split-Mouth Double Blinded Randomized Control Study. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/dentjods.2025.106480.2667
George Samyo Stephenson; Deepak Abraham Pandyan; Satheesh Chandran; Deenadayalan Narasimman; Karthik Kattur Premkumar; Balamurugan Rajendran; Vijayalakshmi Pethuraj. "Efficacy of Leukocyte Platelet Rich Fibrin (L-PRF) Versus L-PRF with βeta Tri-calcium Phosphate (β-TCP) Bone Graft in Mandibular Impacted Third Molar Surgery: A Split-Mouth Double Blinded Randomized Control Study". سامانه مدیریت نشریات علمی, , , 1404, -. doi: 10.30476/dentjods.2025.106480.2667
Stephenson, George, Pandyan, Deepak, Chandran, Satheesh, Narasimman, Deenadayalan, Premkumar, Karthik, Rajendran, Balamurugan, Pethuraj, Vijayalakshmi. (1404). 'Efficacy of Leukocyte Platelet Rich Fibrin (L-PRF) Versus L-PRF with βeta Tri-calcium Phosphate (β-TCP) Bone Graft in Mandibular Impacted Third Molar Surgery: A Split-Mouth Double Blinded Randomized Control Study', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/dentjods.2025.106480.2667
Stephenson, George, Pandyan, Deepak, Chandran, Satheesh, Narasimman, Deenadayalan, Premkumar, Karthik, Rajendran, Balamurugan, Pethuraj, Vijayalakshmi. Efficacy of Leukocyte Platelet Rich Fibrin (L-PRF) Versus L-PRF with βeta Tri-calcium Phosphate (β-TCP) Bone Graft in Mandibular Impacted Third Molar Surgery: A Split-Mouth Double Blinded Randomized Control Study. سامانه مدیریت نشریات علمی, 1404; (): -. doi: 10.30476/dentjods.2025.106480.2667

Efficacy of Leukocyte Platelet Rich Fibrin (L-PRF) Versus L-PRF with βeta Tri-calcium Phosphate (β-TCP) Bone Graft in Mandibular Impacted Third Molar Surgery: A Split-Mouth Double Blinded Randomized Control Study

Journal of Dentistry
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 19 آبان 1404    اصل مقاله (328.7 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/dentjods.2025.106480.2667
نویسندگان
George Samyo Stephenson* 1؛ Deepak Abraham Pandyan2؛ Satheesh Chandran2؛ Deenadayalan Narasimman2؛ Karthik Kattur Premkumar2؛ Balamurugan Rajendran3؛ Vijayalakshmi Pethuraj4
1MADHA DENTAL COLLEGE AND HOSPITAL, CHENNAI, INDIA
2Madha Dental College and Hospital Chennai, India
3RYA MADRAS COSMO FOUNDATION HOSPITAL, CHENNAI, INDIA
4Private Clinical Practitioner Chennai, India
چکیده
Background: Mandibular third molar removal surgically exhibits severe pain, edema, limitation in mouth opening, impaired wound healing, and delayed bone formation postoperatively.
Purpose: To compare the effectiveness of leukocyte platelet-rich fibrin (L-PRF) and L-PRF with β-Tricalcium phosphate (β-TCP) bone graft on postoperative outcomes after mandibular impacted third molar surgery.
Materials and Method: This split-mouth double-blinded randomized controlled study was conducted on 100 patients, who presented for bilateral extraction of mandibular impacted third molars. Group I included 50 patients who were subjected to L-PRF, and group II included 50 patients who were subjected to L-PRF with β-TCP in the extracted socket after removal of the mandibular third molar. The surgical site bleeding was assessed intraoperatively. The pain, swelling, and trismus were evaluated on the 1st, 3rd, and 7th postoperative days. Wound healing was evaluated on the 3rd and 7th postoperative days, and bone density was assessed on the 3rd postoperative month using cone beam computed tomography (CBCT).
Results: Group II patients experienced reduced surgical site bleeding, less postoperative swelling, maximum mouth opening, and improved bone regeneration (p Value< 0.05). Group I patients exhibited faster wound healing and less postoperative pain (p< 0.05).
Conclusion: The results of our study indicate that L-PRF combined with β-TCP remains an excellent and promising biocompatible material for achieving better postoperative outcomes compared to L-PRF alone.
کلیدواژه‌ها
Platelet-rich fibrin؛ Beta-tricalcium phosphate؛ Wound healing؛ Bone density
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