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Hosseinikia, Mahboobe, Panahande, Seyed-Bahman, Roozbehi, Marjan, Mahmoodi, Sara, Sadriirani, Mohammadreza, Samimi, Bahar, Soriano, Jose M., Abbasi, Mehrnaz, Pourmahmoudi, Azizollah. (1404). The Effect of Whole Pomegranate Juice (Punica Granatum) on Nutritional and Immunological Status of Hospitalized Covid-19 Patients. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijns.2025.105819.1407
Mahboobe Hosseinikia; Seyed-Bahman Panahande; Marjan Roozbehi; Sara Mahmoodi; Mohammadreza Sadriirani; Bahar Samimi; Jose M. Soriano; Mehrnaz Abbasi; Azizollah Pourmahmoudi. "The Effect of Whole Pomegranate Juice (Punica Granatum) on Nutritional and Immunological Status of Hospitalized Covid-19 Patients". سامانه مدیریت نشریات علمی, , , 1404, -. doi: 10.30476/ijns.2025.105819.1407
Hosseinikia, Mahboobe, Panahande, Seyed-Bahman, Roozbehi, Marjan, Mahmoodi, Sara, Sadriirani, Mohammadreza, Samimi, Bahar, Soriano, Jose M., Abbasi, Mehrnaz, Pourmahmoudi, Azizollah. (1404). 'The Effect of Whole Pomegranate Juice (Punica Granatum) on Nutritional and Immunological Status of Hospitalized Covid-19 Patients', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijns.2025.105819.1407
Hosseinikia, Mahboobe, Panahande, Seyed-Bahman, Roozbehi, Marjan, Mahmoodi, Sara, Sadriirani, Mohammadreza, Samimi, Bahar, Soriano, Jose M., Abbasi, Mehrnaz, Pourmahmoudi, Azizollah. The Effect of Whole Pomegranate Juice (Punica Granatum) on Nutritional and Immunological Status of Hospitalized Covid-19 Patients. سامانه مدیریت نشریات علمی, 1404; (): -. doi: 10.30476/ijns.2025.105819.1407

The Effect of Whole Pomegranate Juice (Punica Granatum) on Nutritional and Immunological Status of Hospitalized Covid-19 Patients

International Journal of Nutrition Sciences
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 12 آبان 1404    اصل مقاله (543.4 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/ijns.2025.105819.1407
نویسندگان
Mahboobe Hosseinikia1؛ Seyed-Bahman Panahande1؛ Marjan Roozbehi1؛ Sara Mahmoodi1؛ Mohammadreza Sadriirani1؛ Bahar Samimi1؛ Jose M. Soriano2؛ Mehrnaz Abbasi3؛ Azizollah Pourmahmoudi* 1
1Department of Nutrition, School of Health and Nutrition, Yasuj University of Medical Sciences, Yasuj, Iran
2Food and Health Laboratory, Institute of Materials Science, University of Valencia, 46980 Paterna, Spain
3College of Health Solutions, Arizona State University, Phoenix, Arizona, 85004, USA
چکیده
Background: Pomegranate juice may favorably affect nutritional and immunological status. This study set out to explore the nutritionalimmunological effects of pomegranate juice on hospitalized COVID-19 patients.
Methods: We conducted this study as an exploratory randomized clinical trial recruiting 48 COVID-19 patients. Subjects were randomly allocated to intervention and placebo groups. Intervention participants received 500 mL of whole pomegranate juice as a complementary therapy, and control patients received the same amount of placebo for 2 weeks. Controlling nutritional status (CONUT), prognostic nutritional index (PNI) and albumin to globulin ratio (AGR) scores were measured at baseline and the end of the trial.
Results: Forty three patients completed the study. Cholesterol level significantly decreased (p<0.0001), and albumin (p<0.0001), total protein (p=0.03) and lymphocytes (p=0.04) levels significantly increased in the pomegranate juice group. However, the result remained insignificant regarding CONUT, PNI and AGR.
Conclusion: Our intervention showed that pomegranate juice had no significant effect on nutritional-immunological indicators, including CONUT, PNI and AGR scores. However, it did significantly reduced cholesterol level and increased albumin, total protein and lymphocyte levels. Further studies are needed to determine the long-term effects of pomegranate juice consumption on nutritional-immunological indicators and overall health outcomes.
کلیدواژه‌ها
Pomegranate؛ COVID-19؛ Nutrition؛ Immunology؛ Iran
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