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| تعداد مقالات | 11,229 |
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The Role of Urine Alkalinization in Preventing Rhabdomyolysis-Induced Acute Kidney Injury and Need for Dialysis: A Systematic Review and Meta-Analysis | ||
| Bulletin of Emergency And Trauma | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 11 آبان 1404 اصل مقاله (1.63 M) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.30476/beat.2025.107657.1618 | ||
| نویسندگان | ||
| Saeed Safari1؛ Iraj Najafi2؛ Seyedhadi Aghili3؛ Ali Jamshidikerachi* 4؛ Mohammad Amin Shahlaee5؛ Alireza Sadeghi6؛ Mehri Farhangranjbar7 | ||
| 1Research Center for Trauma in Police Operations, Directorate of Health, Rescue & Treatment, Police Headquarter, Tehran, Iran/ Men’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran | ||
| 2Nephrology Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran | ||
| 3Research Center for Trauma in Police Operations, Directorate of Health, Rescue & Treatment, Police Headquarter, Tehran, Iran/ Neurosurgery Department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, | ||
| 4Research Center for Trauma in Police Operations, Directorate of Health, Rescue & Treatment, Police Headquarter, Tehran, Iran/ Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 5Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 6Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran/ Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 7Research Center for Trauma in Police Operations, Directorate of Health, Rescue & Treatment, Police Headquarter, Tehran, Iran/ Department of Medical Surgical Nursing, School of Nursing and Midwifery, Tehran University of Medical | ||
| چکیده | ||
| Objective: This systematic review and meta-analysis aimed to evaluate the efficacy of urine alkalinization in preventing acute kidney injury (AKI) and the need for dialysis in patients with rhabdomyolysis. Methods: This study was conducted in accordance with the PRISMA guideline. A systematic literature search of MEDLINE/ PubMed, Scopus, Web of Science, and Embase databases was conducted. No time or language restrictions were applied to maximize the scope of the results. After removing duplicates, the remaining articles were screened by title, abstract, and study criteria. Two researchers independently assessed the full texts of the remaining studies, with any discrepancies resolved through discussion. The risk of bias was assessed using the ROBINS-I tool, and studies with a critical risk of bias were excluded from the final analysis. Results: Out of 9,230 initially identified articles, five studies met the inclusion criteria for the meta-analysis. The analysis revealed that urine alkalinization was not significantly effective in preventing AKI (OR: 2.11; 95% CI: 0.09-47.72; p=0.3), preventing acute renal failure (OR: 1.26; 95% CI: 0.86-1.84; p=0.36), or reducing the need for dialysis (OR: 4.25; 95% CI: 0-3.8e+07; p=0.25). Conclusion: The addition of sodium bicarbonate to fluid therapy solution did not appear to provide significant protection against AKI, acute renal failure, or the need for dialysis in patients with rhabdomyolysis. Further insight should be sought through controlled randomized clinical trials with larger sample sizes. | ||
| کلیدواژه‌ها | ||
| Rhabdomyolysis؛ Crush injury؛ Urine alkalization؛ Sodium bicarbonate؛ Management | ||
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آمار تعداد مشاهده مقاله: 5 تعداد دریافت فایل اصل مقاله: 6 |
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