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Taghipour, Fatemeh, Norouzi, Mehdi, Taghipour, Ali, Madahali, Mohammad Hossein, Amiri, Zahra, Mosa Farkhani, Ehsan. (1404). Characteristics Associated with COVID-19 Outcomes: A Population-Based Analysis Using SINAEHR® Primary Care Data and Linked Hospital Care Monitoring System. سامانه مدیریت نشریات علمی, 13(4), 375-383. doi: 10.30476/jhsss.2024.102945.1923
Fatemeh Taghipour; Mehdi Norouzi; Ali Taghipour; Mohammad Hossein Madahali; Zahra Amiri; Ehsan Mosa Farkhani. "Characteristics Associated with COVID-19 Outcomes: A Population-Based Analysis Using SINAEHR® Primary Care Data and Linked Hospital Care Monitoring System". سامانه مدیریت نشریات علمی, 13, 4, 1404, 375-383. doi: 10.30476/jhsss.2024.102945.1923
Taghipour, Fatemeh, Norouzi, Mehdi, Taghipour, Ali, Madahali, Mohammad Hossein, Amiri, Zahra, Mosa Farkhani, Ehsan. (1404). 'Characteristics Associated with COVID-19 Outcomes: A Population-Based Analysis Using SINAEHR® Primary Care Data and Linked Hospital Care Monitoring System', سامانه مدیریت نشریات علمی, 13(4), pp. 375-383. doi: 10.30476/jhsss.2024.102945.1923
Taghipour, Fatemeh, Norouzi, Mehdi, Taghipour, Ali, Madahali, Mohammad Hossein, Amiri, Zahra, Mosa Farkhani, Ehsan. Characteristics Associated with COVID-19 Outcomes: A Population-Based Analysis Using SINAEHR® Primary Care Data and Linked Hospital Care Monitoring System. سامانه مدیریت نشریات علمی, 1404; 13(4): 375-383. doi: 10.30476/jhsss.2024.102945.1923

Characteristics Associated with COVID-19 Outcomes: A Population-Based Analysis Using SINAEHR® Primary Care Data and Linked Hospital Care Monitoring System

Journal of Health Sciences & Surveillance System
دوره 13، شماره 4، دی 2025، صفحه 375-383    اصل مقاله (3.66 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/jhsss.2024.102945.1923
نویسندگان
Fatemeh Taghipour1؛ Mehdi Norouzi2؛ Ali Taghipour3؛ Mohammad Hossein Madahali4؛ Zahra Amiri2؛ Ehsan Mosa Farkhani* 5
1Department of Pathology, School of Medicine, Shahid Beheshti University of Medical Sciences Tehran, Iran
2Department of Epidemiology, Faculty of Health, Mashhad University of Medical Sciences, Mashhad, Iran
3Department of Health Education & Health Promotion, Faculty of Health, Mashhad University of Medical Sciences, Mashhad, Iran
4Department of Anatomical Sciences and Cell Biology, Mashhad University of Medical Sciences, Mashhad, Iran
5Department of Epidemiology, School of Health, Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background: Identifying risk factors for severe COVID-19 outcomes is essential for shaping effective public health strategies. This study analyzed demographic, clinical, and comorbidity-related factors associated with hospitalization, ICU admission, mechanical ventilation, and mortality in a large Iranian population.
Methods: We conducted a population-based cross-sectional study of 405,397 individuals registered under the Mashhad University of Medical Sciences, combining primary care records with hospital monitoring data. Variables included age, sex, geographic region, diabetes, hypertension, cardiovascular disease, hyperlipidemia, pregnancy, obesity, and vaccination status. Logistic regression models were applied to examine associations with each outcome.
Results: Among 405,397 individuals (mean age 40.21±16 years; 46.30% female), 4.29% were hospitalized, 0.17% admitted to ICU, 0.42% required mechanical ventilation, and 0.67% died. Advanced age (≥80 years) was the strongest predictor across all outcomes, with adjusted odds ratios (AORs) ranging from 17.21 (95% CI, 15.37–19.28) for hospitalization to 283.31 (95% CI, 155.57–515.93) for mortality. Cardiovascular disease, diabetes, obesity, and pregnancy were also significant risk factors. In contrast, female sex (AOR for mortality: 0.63; 95% CI, 0.58– 0.69), hypertension, and hyperlipidemia were associated with reduced risks. Vaccination demonstrated a strong dose-dependent protective effect, with three doses reducing the odds of mortality by 93% (AOR: 0.07; 95% CI, 0.05–0.12).
Conclusion: Advanced age, cardiovascular disease, diabetes, obesity, and pregnancy emerged as major risk factors for severe COVID-19 outcomes. The apparent protective associations of female sex, hypertension, and hyperlipidemia warrant further exploration. Most critically, the profound protective effect of vaccination highlights the urgent need to sustain and expand comprehensive immunization programs.
کلیدواژه‌ها
COVID-19؛ Risk factors؛ Hospitalization؛ Mortality؛ Immunization
مراجع
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