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| تعداد شماره‌ها | 1,230 |
| تعداد مقالات | 11,205 |
| تعداد مشاهده مقاله | 78,028,779 |
| تعداد دریافت فایل اصل مقاله | 103,608,253 |
The Prognostic Value of D-Dimer Levels for Injury Outcomes in Trauma Patients: A Systematic Review and Meta-Analysis | ||
| Bulletin of Emergency And Trauma | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 05 آبان 1404 اصل مقاله (1.7 M) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.30476/beat.2025.106988.1605 | ||
| نویسندگان | ||
| Hooman Rezaei1؛ Elham Navipour2؛ Samane Zafarabadi3؛ Mehrdad Karajizadeh4؛ Fatemeh Javanmardi5؛ Mahnaz Yadollahi6؛ Maryam Hosseini* 7 | ||
| 1Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 2Department of Medical Education, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 3Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Khorasan Razavi, Iran | ||
| 4Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Fars, Iran | ||
| 5Department of Biostatistics, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Fars, Iran | ||
| 6Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 7Trauma Research Center, Shahid Rajaee (Emtiaz) Truama Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| چکیده | ||
| Objectives: This study aimed to systematically review and quantify the association between D-dimer levels and injury outcomes in trauma patients through a meta-analysis. Methods: A systematic literature search of PubMed, MEDLINE/PubMed, and Web of Science was conducted from 2011 to 2023, supplemented by manual reference list searches. Two independent reviewers assessed the risk of bias using the Newcastle-Ottawa Scale. The primary outcomes were mortality and deep vein thrombosis (DVT). Results: Of 84 identified articles, 17 were eligible for full-text assessment, and 12 were included in the final analysis. A random-effects model was used to pool the study results. The analysis revealed a statistically significant difference in mean D-dimer levels between patients with poor outcomes and those without poor outcomes (p=0.0003). The standardized mean difference (SMD) was 0.51 (95% confidence interval [CI]:0.24 to 0.79). Furthermore, a significant difference in mean D-dimer levels was observed between survivors and non-survivors (p=0.03, SMD:0.42, 95% CI:0.04-0.79) and between patients with DVT and those without DVT (p=0.0008, SMD:0.79, 95% CI:0.32-1.25). Conclusion: This meta-analysis indicated that elevated D-dimer levels upon admission could be a valuable prognostic marker in trauma patients and might help predict poor outcomes. | ||
| کلیدواژه‌ها | ||
| D-dimer؛ Meta-analysis؛ Mortality؛ Trauma brain injury؛ Deep vein thrombosis | ||
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آمار تعداد مشاهده مقاله: 15 تعداد دریافت فایل اصل مقاله: 24 |
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