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Sadrzadeh, Sayyed majid, Montazeri, Ala, Rezvani Kakhki, Behrang, Vafadar Moradi, Elnaz. (1404). Haloperidol versus Ketamine for Managing Acute Agitation in the Emergency Department: A Randomized Clinical Trial. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/beat.2025.106204.1583
Sayyed majid Sadrzadeh; Ala Montazeri; Behrang Rezvani Kakhki; Elnaz Vafadar Moradi. "Haloperidol versus Ketamine for Managing Acute Agitation in the Emergency Department: A Randomized Clinical Trial". سامانه مدیریت نشریات علمی, , , 1404, -. doi: 10.30476/beat.2025.106204.1583
Sadrzadeh, Sayyed majid, Montazeri, Ala, Rezvani Kakhki, Behrang, Vafadar Moradi, Elnaz. (1404). 'Haloperidol versus Ketamine for Managing Acute Agitation in the Emergency Department: A Randomized Clinical Trial', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/beat.2025.106204.1583
Sadrzadeh, Sayyed majid, Montazeri, Ala, Rezvani Kakhki, Behrang, Vafadar Moradi, Elnaz. Haloperidol versus Ketamine for Managing Acute Agitation in the Emergency Department: A Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 1404; (): -. doi: 10.30476/beat.2025.106204.1583

Haloperidol versus Ketamine for Managing Acute Agitation in the Emergency Department: A Randomized Clinical Trial

Bulletin of Emergency And Trauma
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 05 آبان 1404    اصل مقاله (984.21 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/beat.2025.106204.1583
نویسندگان
Sayyed majid Sadrzadeh1؛ Ala Montazeri2؛ Behrang Rezvani Kakhki1؛ Elnaz Vafadar Moradi* 3
1Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran
2Student research center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran
3Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
چکیده
Objective: The primary outcome was the management of acute agitation, as measured by the Richmond
Agitation-Sedation Scale (RASS). Secondary outcomes included the incidence of adverse effects and the time
to onset of the therapeutic effect.
Methods: This randomized clinical trial was conducted between March 2021 and March 2022. Participants
were recruited from patients presenting with acute agitation who required pharmacological intervention at
Emam Reza and Shahid Hasheminejad hospitals (Mashhad, Iran). Eligible participants were adults aged 18 to
65 years. Using a block randomization method with a block size of four, patients were assigned to receive either
5 mg of intravenous (IV) haloperidol or 2 mg/Kg of IV ketamine. Data were analyzed using SPSS software
(version 22).
Results: A total of 120 participants were randomized. The majority were male, comprising 43 (73%) in the
haloperidol group and 45 (75%) in the ketamine group. The mean age was 45.42±16.65 in the ketamine group
and 48.28±16.75 years in the haloperidol group (p=0.34). In the haloperidol group, the mean admission RASS
score was 1.73±0.75, which decreased to 0.07±1.25 post-intervention. In the ketamine group, the mean admission
RASS score was 1.58±0.61, which improved to -0.92±1.19 following treatment.
Conclusion: Ketamine demonstrated a faster onset of action in managing acute agitation than haloperidol.
These findings suggested that ketamine might represent a viable first-line therapeutic
کلیدواژه‌ها
Emergence delirium؛ Psychomotor agitation؛ Ketamine؛ Haloperidol؛ Emergency
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