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Yeleupayeva, Shynar, Dinmukhamedova, Aigul, Aizman, Roman, Mukataeva, Zhanat, Baidalinova, Bibenur, Bazarbaeva, Saule, Zhakupov, Muhametkali, Rakhimzhanova, Zhanar, Kuzenbayeva, Aisulu. (1404). Current Trends in Antibiotic Resistance Patterns of Pathogens in Urinary Tract Infections in Children in Karaganda, Kazakhstan. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijms.2025.105826.3980
Shynar Yeleupayeva; Aigul Dinmukhamedova; Roman Aizman; Zhanat Mukataeva; Bibenur Baidalinova; Saule Bazarbaeva; Muhametkali Zhakupov; Zhanar Rakhimzhanova; Aisulu Kuzenbayeva. "Current Trends in Antibiotic Resistance Patterns of Pathogens in Urinary Tract Infections in Children in Karaganda, Kazakhstan". سامانه مدیریت نشریات علمی, , , 1404, -. doi: 10.30476/ijms.2025.105826.3980
Yeleupayeva, Shynar, Dinmukhamedova, Aigul, Aizman, Roman, Mukataeva, Zhanat, Baidalinova, Bibenur, Bazarbaeva, Saule, Zhakupov, Muhametkali, Rakhimzhanova, Zhanar, Kuzenbayeva, Aisulu. (1404). 'Current Trends in Antibiotic Resistance Patterns of Pathogens in Urinary Tract Infections in Children in Karaganda, Kazakhstan', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijms.2025.105826.3980
Yeleupayeva, Shynar, Dinmukhamedova, Aigul, Aizman, Roman, Mukataeva, Zhanat, Baidalinova, Bibenur, Bazarbaeva, Saule, Zhakupov, Muhametkali, Rakhimzhanova, Zhanar, Kuzenbayeva, Aisulu. Current Trends in Antibiotic Resistance Patterns of Pathogens in Urinary Tract Infections in Children in Karaganda, Kazakhstan. سامانه مدیریت نشریات علمی, 1404; (): -. doi: 10.30476/ijms.2025.105826.3980

Current Trends in Antibiotic Resistance Patterns of Pathogens in Urinary Tract Infections in Children in Karaganda, Kazakhstan

Iranian Journal of Medical Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 29 مهر 1404    اصل مقاله (710.32 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2025.105826.3980
نویسندگان
Shynar Yeleupayeva1، 2؛ Aigul Dinmukhamedova* 1؛ Roman Aizman3؛ Zhanat Mukataeva1؛ Bibenur Baidalinova4؛ Saule Bazarbaeva5؛ Muhametkali Zhakupov6؛ Zhanar Rakhimzhanova7؛ Aisulu Kuzenbayeva8
1Department of General Biology and Genomics, L.N. Gumilyov Eurasian National University, Astana, Kazakhstan
2Department of Zoology, Karaganda Buketov University, Karaganda, Kazakhstan
3Department of Anatomy, Physiology and Life Safety, Novosibirsk State Pedagogical University, Novosibirsk, Russian
4Higher School of Natural Science, Pavlodar State Pedagogical University, Pavlodar, Kazakhstan
5Department of Biology, M. Kozybayev North-Kazakhstan State University, Petropavlovsk, Kazakhstan
6Department of Internal Diseases, Astana Medical University, Astana, Kazakhstan
7Department of Normal Physiology, Astana Medical University, Astana, Kazakhstan
8Department of Medical Genetics and Molecular Biology, Astana Medical University, Astana, Kazakhstan
چکیده
Background: Urinary tract infections (UTIs) are common in children and result in frequent hospitalization, creating a social and economic burden for parents and the healthcare system. This study analyzes the patterns of antibiotic resistance of dominant uropathogens and assesses the impact of patient age and sex on these patterns.
Methods: This retrospective cohort study was conducted in Karaganda, Kazakhstan, between 2017 and 2022. Antibiotic resistance was assessed in two age groups: 0-12 months (Group I) and 13-60 months (Group II). Standard microbiological methods were used to identify UTI pathogens, and antibiotic resistance patterns were determined using the Kirby-Bauer disk diffusion method.
Results: Among the 519 isolates (68.1%) from 762 children, the most common pathogens were Escherichia coli (170, 32.7%), Enterococcus faecalis (80, 15.4%), and Staphylococcus epidermidiss (46, 8.9%) in both age groups. Antimicrobial resistance in common pathogens in Groups I and II was high for amoxicillin (33 isolates, 76.7% and 45 isolates, 73.8%) and erythromycin (14 isolates, 73.7% and five isolates, 55.5%). Imipenem (31 isolates, 94%), amikacin (45 isolates, 90%), and meropenem (47 isolates, 87%) were effective against E. coli, whereas ceftriaxone (31 isolates, 97%) was more active against Gram-positive cocci. 157 (34%) uropatogens were resistant to multiple drugs, increasing with age: 72 (28%) (Group I) and 85 (43%) (Group II).
Conclusion: The study demonstrated a progressive increase in the prevalence of multidrug-resistant uropathogens with age in the pediatric population. Periodic monitoring of uropathogens helps track the growth of multidrug-resistant strains.

تازه های تحقیق

Shynar Yeleupayeva (Google Scholar)

Aigul Dinmukhamedova (Google Scholar)

کلیدواژه‌ها
Urinary tract infections؛ Urination disorders؛ Anti-bacterial agents؛ Microbiology؛ Infection control
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