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Hadi Nassar Al-Tamimi, Ali Hussein, Heydari, Nadia, Mohammadi, Saeed, Abdolahi, Nafiseh, Jafari, Seyyed Mehdi. (1404). Elevated Serum Levels of CTRP-6 and Asprosin in Systemic Lupus Erythematosus: Association with Oxidative Stress Markers and Clinical Manifestations. سامانه مدیریت نشریات علمی, 22(3), 8-8. doi: 10.22034/iji.2025.105623.2961
Ali Hussein Hadi Nassar Al-Tamimi; Nadia Heydari; Saeed Mohammadi; Nafiseh Abdolahi; Seyyed Mehdi Jafari. "Elevated Serum Levels of CTRP-6 and Asprosin in Systemic Lupus Erythematosus: Association with Oxidative Stress Markers and Clinical Manifestations". سامانه مدیریت نشریات علمی, 22, 3, 1404, 8-8. doi: 10.22034/iji.2025.105623.2961
Hadi Nassar Al-Tamimi, Ali Hussein, Heydari, Nadia, Mohammadi, Saeed, Abdolahi, Nafiseh, Jafari, Seyyed Mehdi. (1404). 'Elevated Serum Levels of CTRP-6 and Asprosin in Systemic Lupus Erythematosus: Association with Oxidative Stress Markers and Clinical Manifestations', سامانه مدیریت نشریات علمی, 22(3), pp. 8-8. doi: 10.22034/iji.2025.105623.2961
Hadi Nassar Al-Tamimi, Ali Hussein, Heydari, Nadia, Mohammadi, Saeed, Abdolahi, Nafiseh, Jafari, Seyyed Mehdi. Elevated Serum Levels of CTRP-6 and Asprosin in Systemic Lupus Erythematosus: Association with Oxidative Stress Markers and Clinical Manifestations. سامانه مدیریت نشریات علمی, 1404; 22(3): 8-8. doi: 10.22034/iji.2025.105623.2961

Elevated Serum Levels of CTRP-6 and Asprosin in Systemic Lupus Erythematosus: Association with Oxidative Stress Markers and Clinical Manifestations

Iranian Journal of Immunology
دوره 22، شماره 3، آذر 2025، صفحه 8-8
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2025.105623.2961
نویسندگان
Ali Hussein Hadi Nassar Al-Tamimi1، 2؛ Nadia Heydari1، 2؛ Saeed Mohammadi3، 4؛ Nafiseh Abdolahi5؛ Seyyed Mehdi Jafari* 1، 2
1Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
2Department of Biochemistry and Biophysics, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
3Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.
4Natural and Medical Sciences Research Center, University of Nizwa, 611, Oman.
5Golestan Rheumatology Research Center, Golestan University of Medical Science, Gorgan, Iran.
چکیده
Background: Systemic Lupus Erythematosus (SLE) is a chronic inflammatory disease that affects multiple organ systems. The resulting inflammation disrupts adipocyte metabolism, thereby altering the levels of adipokines.
Objective: To assess e serum levels of Asprosin and CTRP-6 as novel adipokines in SLE patients compared to controls, and their association with lipid profiles, oxidative stress markers, and clinical parameters.
Methods: This case-control study involved 41 SLE patients and 41 healthy controls. Serum CTRP-6 and Asprosin levels were measured using ELISA, while total antioxidant capacity (TAC) and malondialdehyde levels were measured using a colorimetric assay.
Results: The mean serum CTRP-6 level was significantly higher in individuals with SLE (1.08±0.32) compared to healthy subjects (0.82 0.21; P<0.001). Similarly, the serum level of Asprosin was elevated in patients with SLE (11.91 ± 3.09) compared to the control group (10.28 ± 2.09; P < 0.001). In contrast, the TAC level was lower in subjects with SLE than in healthy controls (0.18±0.23, 0.19 0.51 respectively; p<0.001). Additionally, the serum level of Asprosin was significantly reduced in SLE patients with nephritis (10.17 ± 3.55) compared to those without nephritis (12.4 ± 2.75; p = 0.005).
Conclusion: Elevated levels of Asprosin and CTRP-6 suggest a potential role for these adipokines in SLE pathogenesis. Moreover, the presence of nephritis in SLE patients was associated with reduced plasma levels of Asprosin.
کلیدواژه‌ها
Asprosin؛ CTRP-6؛ Systemic Lupus Erythematosus
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