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Serum ACE2 and Anti-MMR Antibody Profiles in Pediatric Patients with and without SARS-CoV-2 Infection | ||
| Iranian Journal of Immunology | ||
| دوره 22، شماره 3، آذر 2025، صفحه 251-259 اصل مقاله (695.34 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2025.104055.2879 | ||
| نویسندگان | ||
| Zohre Labbani-Motlagh1، 2؛ Zohreh Nozarian3؛ Mohammad Taghi Haghi Ashtiani4؛ Sajjadeh Movahedinia5؛ Mohammad Vasei6؛ Negin Hosseini Rouzbahani* 7 | ||
| 1Infectious Diseases Research Center, Aja University of Medical Sciences, Tehran, Iran. | ||
| 2Clinical Research Development Unit, Imam Reza Hospital, Aja University of Medical Sciences, Tehran, Iran. | ||
| 3Department of Molecular Pathology and Cytogenetics, Farabi Hospital, Tehran University of Medical Sciences, Tehran, Iran. | ||
| 4Department of Pathology, Children’s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran. | ||
| 5Department of Molecular Pathology and Cytogenetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. | ||
| 6Gene Therapy Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. | ||
| 7Department of Medical Immunology, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran. | ||
| چکیده | ||
| Background: Coronavirus Disease 2019 (COVID-19) typically manifests with milder symptoms and lower mortality rates in children when compared to adults. Objective: To investigate potential mechanisms underlying this age-related protection, we examined whether serum levels of angiotensin-converting enzyme 2 (ACE2) and IgG antibody titers against Measles, Mumps, and Rubella (MMR) vaccines are associated with susceptibility to SARS-CoV-2 infection in the pediatric population. Methods: In this case-control study, conducted before the introduction of mass COVID-19 vaccination, we enrolled children aged 1–15 years. The cases were hospitalized children with confirmed COVID-19, while the control group consisted of outpatients with non-infectious, non-immunodeficient conditions and no documented history of COVID-19. The COVID-19 status was confirmed using RT-PCR. Serum levels of ACE2 and anti-MMR IgG antibodies were assessed using ELISA. Results: Eighty-three patients including 39 cases with COVID-19 infection and 44 controls were enrolled in this study. The median serum ACE2 levels were 3.6 in COVID-19 cases and 3.8 ng/mL in control cases (P=0.440). Similarly, antibody levels against Mumps (P=0.788), Measles (P=0.281), and Rubella (P=0.083) did not differ significantly between the groups, although Rubella seropositivity was more frequent in COVID-19 cases than in controls (P=0.039). Conclusions: Our findings did not support a significant association between serum ACE2 levels or MMR antibody titers and protection against COVID-19 in children. The higher prevalence of Rubella seropositivity among infected cases may suggest possible cross-reactivity, but causal relationships could not be established in this study. | ||
| کلیدواژه‌ها | ||
| ACE2؛ COVID-19؛ Measles؛ MMR vaccine؛ Mumps؛ Rubella؛ SARS-CoV-2 | ||
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آمار تعداد مشاهده مقاله: 350 تعداد دریافت فایل اصل مقاله: 50 |
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