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Tejaswi siddappa, Poornachandra, Sunkappa, Shamsundar, Kunigal Puttaswamy, Jagannath, Ramanand, Nanda, Katke, Aradhana, Boraiah, Thejaswini. (1404). Quad Shot Like Radiotherapy with Concurrent Chemotherapy for Advanced Head and Neck Cancer. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/mejc.2025.104769.2205
Poornachandra Tejaswi siddappa; Shamsundar Sunkappa; Jagannath Kunigal Puttaswamy; Nanda Ramanand; Aradhana Katke; Thejaswini Boraiah. "Quad Shot Like Radiotherapy with Concurrent Chemotherapy for Advanced Head and Neck Cancer". سامانه مدیریت نشریات علمی, , , 1404, -. doi: 10.30476/mejc.2025.104769.2205
Tejaswi siddappa, Poornachandra, Sunkappa, Shamsundar, Kunigal Puttaswamy, Jagannath, Ramanand, Nanda, Katke, Aradhana, Boraiah, Thejaswini. (1404). 'Quad Shot Like Radiotherapy with Concurrent Chemotherapy for Advanced Head and Neck Cancer', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/mejc.2025.104769.2205
Tejaswi siddappa, Poornachandra, Sunkappa, Shamsundar, Kunigal Puttaswamy, Jagannath, Ramanand, Nanda, Katke, Aradhana, Boraiah, Thejaswini. Quad Shot Like Radiotherapy with Concurrent Chemotherapy for Advanced Head and Neck Cancer. سامانه مدیریت نشریات علمی, 1404; (): -. doi: 10.30476/mejc.2025.104769.2205

Quad Shot Like Radiotherapy with Concurrent Chemotherapy for Advanced Head and Neck Cancer

Middle East Journal of Cancer
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 11 دی 1404    اصل مقاله (490.47 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2025.104769.2205
نویسندگان
Poornachandra Tejaswi siddappa* 1؛ Shamsundar Sunkappa2؛ Jagannath Kunigal Puttaswamy2؛ Nanda Ramanand2؛ Aradhana Katke2؛ Thejaswini Boraiah2
1Department of Radiation Oncology, Karnataka cancer therapy and research institute, Navanagar, Hubli-580025.
2Department of Radiation Oncology, Kidwai memorial institute of oncology, Hombegowda Nagar, Bengaluru, Karnataka, India-560029.
چکیده
Background: Improvement in quality of life and palliation of symptoms forms the primary end point in patients unfit for definitive treatment modalities. Quad-shot like radiotherapy aims to achieve these objectives with addition of chemotherapy in advanced head and neck malignancy.
Methods
In this study, patients >18 years of age, with advanced head and neck malignancy (stage IVA&B) in non-nasopharyngeal sub-site, not fit for radical treatment were included in this mono-centric, prospective, interventional study. Quad-shot like regimen of 14.4Gray in 4fractions delivered with concurrent carboplatin (AUC2) on day-1 of radiation cycle and reviewed after 3-weeks. Based on palliative response, total two repetition are done. Quality of life analysis was done with European Organization for Research and Treatment– Head & Neck-35 questionnaire Treatment induced toxicity evaluated with common terminology criteria for adverse event version 5.0 and radiation therapy oncology group toxicity grading. Treatment outcome was assessed with response evaluation criteria in solid tumors1.1. Microsoft-excel, SPSS version-22 used to analyze data. Kaplan-Meier survival curves were used for overall survival, P-value<0.05 with Pearson chi-square test and ANOVA was considered as statistically significant.
Results
The palliation of symptoms and improvement in quality of life were recorded in 80% and sustained up to 3 months, with median overall survival of 8±0.411 months, maximum benefit appreciable with larynx compared to other sub-sites. However, grade-4 toxicity reported with one patient in post phase-1 and two patients in post phase-2 and managed with best supportive care.
Conclusion
Quad-shot like radiotherapy with concurrent chemotherapy for advanced head and cancer found to be beneficial in patients unfit for radical treatment resulting in desirable palliative outcome.
کلیدواژه‌ها
Radiation Dose Hypofractionation؛ Carboplatin؛ Palliative Care؛ Quality of Life؛ Squamous Cell Carcinoma of Head and Neck
مراجع
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