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Mehrad-Majd, Hassan, Ravanshad, Sahar, Taherynejad, Mohammadhossein, Aliakbarian, Mohsen, Asgharian Rezaei, Mojtaba, Dalili, Amin, Sheikhi, Maryam. (1404). Prognostic Significance of LncRNA PANDAR Expression Levels in Patients with Hepatocellular Carcinoma. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/mejc.2025.104519.2187
Hassan Mehrad-Majd; Sahar Ravanshad; Mohammadhossein Taherynejad; Mohsen Aliakbarian; Mojtaba Asgharian Rezaei; Amin Dalili; Maryam Sheikhi. "Prognostic Significance of LncRNA PANDAR Expression Levels in Patients with Hepatocellular Carcinoma". سامانه مدیریت نشریات علمی, , , 1404, -. doi: 10.30476/mejc.2025.104519.2187
Mehrad-Majd, Hassan, Ravanshad, Sahar, Taherynejad, Mohammadhossein, Aliakbarian, Mohsen, Asgharian Rezaei, Mojtaba, Dalili, Amin, Sheikhi, Maryam. (1404). 'Prognostic Significance of LncRNA PANDAR Expression Levels in Patients with Hepatocellular Carcinoma', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/mejc.2025.104519.2187
Mehrad-Majd, Hassan, Ravanshad, Sahar, Taherynejad, Mohammadhossein, Aliakbarian, Mohsen, Asgharian Rezaei, Mojtaba, Dalili, Amin, Sheikhi, Maryam. Prognostic Significance of LncRNA PANDAR Expression Levels in Patients with Hepatocellular Carcinoma. سامانه مدیریت نشریات علمی, 1404; (): -. doi: 10.30476/mejc.2025.104519.2187

Prognostic Significance of LncRNA PANDAR Expression Levels in Patients with Hepatocellular Carcinoma

Middle East Journal of Cancer
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 09 مهر 1404    اصل مقاله (473.5 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2025.104519.2187
نویسندگان
Hassan Mehrad-Majd* 1؛ Sahar Ravanshad2؛ Mohammadhossein Taherynejad3؛ Mohsen Aliakbarian4؛ Mojtaba Asgharian Rezaei2؛ Amin Dalili4؛ Maryam Sheikhi5
1Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
2Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
5Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background: Long non-coding RNAs (LncRNAs) have been implicated in various biological processes and tumorigenesis. PANDAR is one of the long non-coding RNAs implicated in the development of multiple cancers, which has yet to be investigated for its clinical significance in hepatocellular carcinoma (HCC). Therefore, this study aimed to investigate the clinical significance of PANDAR in a cohort of Iranian patients with HCC.
Method: In this cross-sectional study, real-time quantitative polymerase chain reaction (PCR) was employed to analyze the expression levels of PANDAR in 22 paired HCC and adjacent normal tissues. Patients were subsequently stratified into high- and low-expression subgroups based on PANDAR expression levels. The associations between PANDAR expression, clinicopathological features, and overall survival were evaluated and analyzed using appropriate statistical tests.
Results: The results showed that PANDAR expression was significantly increased in HCC tumor tissues compared with adjacent normal tissues (P = 0.03, fold change = 2.04). Although Kaplan-Meier analysis did not reveal a significant difference in mean overall survival between the high- and low-expression groups (P = 0.215), Cox regression analysis identified an independent predictor role of PANDAR expression in HCC, both in univariate (hazard ratio (HR)=1.74, 95% confidence interval (CI): 1.10-2.99, P = 0.04) and multivariate (HR=1.74, 95%CI: 1.01-3.901, P = 0.05) models.
Conclusion: This study suggests that elevated PANDAR expression is associated with poor prognosis in HCC patients, thereby highlighting its potential clinical utility as a promising prognostic biomarker and therapeutic target.

تازه های تحقیق
کلیدواژه‌ها
Hepatocellular carcinoma؛ long non-coding RNA PANDAR؛ Biomarkers؛ Gene expression؛ Prognosis
مراجع
  1. Foglia B, Turato C, Cannito S. Hepatocellular carcinoma: Latest research in pathogenesis, detection and treatment. Int J Mol Sci. 2023;24(15):12224. doi: 10.3390/ijms241512224. PMID: 37569600; PMCID: PMC10419038.
  2. Asafo-Agyei KO, Samant H. Hepatocellular carcinoma. 2023 Jun 12. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 32644603.
  3. Chakraborty E, Sarkar D. Emerging therapies for hepatocellular carcinoma (HCC). Cancers (Basel). 2022;14(11):2798. doi: 10.3390/cancers14112798. PMID: 35681776; PMCID: PMC9179883.
  4. Das S, Dey MK, Devireddy R, Gartia MR. Biomarkers in cancer detection, diagnosis, and prognosis. Sensors (Basel). 2023;24(1):37. doi: 10.3390/s24010037. PMID: 38202898; PMCID: PMC10780704.
  5. Yuan D, Chen Y, Li X, Li J, Zhao Y, Shen J, et al. Long non-coding RNAs: Potential biomarkers and targets for hepatocellular carcinoma therapy and diagnosis. Int J Biol Sci. 2021;17(1):220-35. doi: 10.7150/ijbs.50730. PMID: 33390845; PMCID: PMC7757045.
  6. Huang HW, Xie H, Ma X, Zhao F, Gao Y. Upregulation of LncRNA PANDAR predicts poor prognosis and promotes cell proliferation in cervical cancer. Eur Rev Med Pharmacol Sci. 2017;21(20):4529-35. PMID: 29131264.
  7. Jiang Y, Feng E, Sun L, Jin W, You Y, Yao Y, et al. An increased expression of long non-coding RNA PANDAR promotes cell proliferation and inhibits cell apoptosis in pancreatic ductal adenocarcinoma. Biomed Pharmacother. 2017;95:685-91. doi: 10.1016/j.biopha.2017.08.124. PMID: 28886528.
  8. Lu M, Liu Z, Li B, Wang G, Li D, Zhu Y. The high expression of long non-coding RNA PANDAR indicates a poor prognosis for colorectal cancer and promotes metastasis by EMT pathway. J Cancer Res Clin Oncol. 2017;143(1):71-81. doi: 10.1007/s00432-016-2252-y. PMID: 27629879.
  9. Li X, Wang F, Sun Y, Fan Q, Cui G. Expression of long non-coding RNA PANDAR and its prognostic value in colorectal cancer patients. Int J Biol Markers. 2017;32(2):e218-e223. doi: 10.5301/jbm.5000249. PMID: 28106228.
  10. Han L, Zhang EB, Yin DD, Kong R, Xu TP, Chen WM, et al. Low expression of long noncoding RNA PANDAR predicts a poor prognosis of non-small cell lung cancer and affects cell apoptosis by regulating Bcl-2. Cell Death Dis. 2015;6(2):e1665. doi: 10.1038/cddis.2015.30. PMID: 25719249; PMCID: PMC4669812.
  11. Zhan Y, Lin J, Liu Y, Chen M, Chen X, Zhuang C, et al. Correction: Up-regulation of long non-coding RNA PANDAR is associated with poor prognosis and promotes tumorigenesis in bladder cancer. J Exp Clin Cancer Res. 2023;42(1):185. doi: 10.1186/s13046-023-02773-3. Erratum for: J Exp Clin Cancer Res. 2016;35(1):83. doi: 10.1186/s13046-016-0354-7. PMID: 37507730; PMCID: PMC10385883.
  12. Ma P, Xu T, Huang M, Shu Y. Increased expression of LncRNA PANDAR predicts a poor prognosis in gastric cancer. Biomed Pharmacother. 2016;78:172-6. doi: 10.1016/j.biopha.2016.01.025. PMID: 26898439.
  13. Peng W, Fan H. Long non-coding RNA PANDAR correlates with poor prognosis and promotes tumorigenesis in hepatocellular carcinoma. Biomed Pharmacother. 2015;72:113-8. doi: 10.1016/j.biopha.2015.04.014. PMID: 26054684.
  14. Xu Y, Tong Y, Zhu J, Lei Z, Wan L, Zhu X, et al. An increase in long non-coding RNA PANDAR is associated with poor prognosis in clear cell renal cell carcinoma. BMC Cancer. 2017;17(1):373. doi: 10.1186/s12885-017-3339-9. PMID: 28545465; PMCID: PMC5445460.
  15. Mehrad-Majd H, Akhtari J, Haerian MS, Ravanshad Y. Clinicopathological and prognostic value of lncRNA PANDAR expression in solid tumors: Evidence from a systematic review and meta-analysis. J Cell Physiol. 2019;234(4):4206-16. doi: 10.1002/jcp.27179. PMID: 30191982.
  16. Fattahi N, Rezaei N, Asadi-Lari M, Yousefi M, Madadi Z, Gohari K, et al. Hepatocellular carcinoma incidence at national and provincial levels in Iran from 2000 to 2016: A meta-regression analysis. PLoS One. 2021;16(1):e0245468. doi: 10.1371/journal.pone.0245468. PMID: 33481849; PMCID: PMC7822534..
  17. Galicia-Moreno M, Silva-Gomez JA, Lucano-Landeros S, Santos A, Monroy-Ramirez HC, Armendariz-Borunda J. Liver cancer: Therapeutic challenges and the importance of experimental models. Can J Gastroenterol Hepatol. 2021;2021:8837811. doi: 10.1155/2021/8837811. PMID: 33728291; PMCID: PMC7937489.
  18. Lee JT. Epigenetic regulation by long noncoding RNAs. Science. 2012;338(6113):1435-9. doi: 10.1126/science.1231776. PMID: 23239728.
  19. Puvvula PK, Desetty RD, Pineau P, Marchio A, Moon A, Dejean A, et al. Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit. Nat Commun. 2014;5:5323. doi: 10.1038/ncomms6323. PMID: 25406515; PMCID: PMC4263151.
  20. Peng C, Hu W, Weng X, Tong R, Cheng S, Ding C, et al. Over expression of long non-coding RNA PANDA promotes hepatocellular carcinoma by inhibiting senescence associated inflammatory factor IL8. Sci Rep. 2017;7(1):4186. doi: 10.1038/s41598-017-04045-5. PMID: 28646235; PMCID: PMC5482898.
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