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Hairy Cell Leukemia Variant Masquerading as Acute Leukemia: A Rare Case Report | ||
| Middle East Journal of Cancer | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 09 مهر 1404 اصل مقاله (211.53 K) | ||
| نوع مقاله: Case Report(s) | ||
| شناسه دیجیتال (DOI): 10.30476/mejc.2025.104377.2176 | ||
| نویسندگان | ||
| Shruthi Swamy* 1؛ Shashidhar V Karpurmath2؛ Manjunath Nandennavar2؛ Veerendra Angadi2 | ||
| 1Vydehi Institute of Medical Sciences & Research Centre | ||
| 2Department of Medical Oncology, Vydehi Institute of Medical Sciences & Research Centre | ||
| چکیده | ||
| The key purpose of this report is to present an uncommon case of hairy cell leukemia variant (HCLv). HCLv is found to be a striking clinico-pathological condition which encompasses the features of classical hairy cell leukemia (cHCL) as well as B cell prolymphocytic leukemia. It is a rather rare entity accounting for 0.4% of all chronic lymphoid malignancies and about 10% of all HCL cases diagnosed worldwide. A 57-year-old man presented with pain abdomen, loss of weight, spikes of fever and massive splenomegaly to our center. Complete blood count showed leucocytosis with 60% blasts on smear. Bone marrow studies were suggestive of acute leukemia like picture. Flow cytometry revealed the markers CD11c, CD19 and CD103 to be positive. This confirmed the diagnosis of HCLv. Other differential diagnoses such as splenic marginal zone lymphoma, B cell Prolymphocytic Leukemia and cHCL should be ruled out before confirming HCLv as each of them have different responses to antimetabolites, splenectomy and BRAF inhibitors. | ||
تازه های تحقیق | ||
| کلیدواژه‌ها | ||
| Leukemia؛ Hairy cell؛ Splenomegaly؛ B cell leukemia؛ Case report | ||
| مراجع | ||
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1. Ashangari C, Cheruku D, Tumula PK. Hairy cell leukemia variant. Blood. 2018; (Supplement 1):5562. doi:10.1182/blood-2018-99-110192. 2. Cawley JC, Burns GF, Hayhoe FG. A chronic lymphoproliferative disorder with distinctive features: a distinct variant of hairy-cell leukaemia. Leuk Res. 1980;4(6):547-59. doi: 10.1016/0145-2126(80)90066-1. PMID: 7206776. 3. Pande P, Yelikar BR, Kumar UM. A hairy cell leukaemia variant - a rare case report. J Clin Diagn Res. 2013;7(2):358-60. doi: 10.7860/JCDR/2013/5169.2768. PMID: 23543122; PMCID: PMC3592312. 4. Jones G, Parry-Jones N, Wilkins B, Else M, Catovsky D; British Committee for Standards in Haematology. Revised guidelines for the diagnosis and management of hairy cell leukaemia and hairy cell leukaemia variant*. Br J Haematol. 2012;156(2):186-95. doi: 10.1111/j.1365-2141.2011.08931.x. PMID: 22111844. 5. Chatterjee T, Panigrahi I, Mahapatra M, Pati HP, Kumar R, Naithani R, et al. Hairy cell leukemia: clinical, pathological and ultrastructural findings in Asian-Indians. Indian J Cancer. 2008;45(2):41-4. doi: 10.4103/0019-509x.41768. PMID: 18626146. 6. Otieno SB, Ogbeide O. Remarkable response of hairy cell leukemia variant to single-agent cladribine. Cureus. 2022;14(5):e24976. doi: 10.7759/cureus.24976. PMID: 35698717; PMCID: PMC9188828. | ||
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