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Mazumder, Avishek, Debbarma, Payeli, Rahaman, Sk Sabir, Chakraborty Das, Susmita. (1404). Efficacy and safety of Amlodipine with Torsemide in CKD with hypertension in tertiary care hospital: A prospective observational study. سامانه مدیریت نشریات علمی, 11(3), -. doi: 10.30476/tips.2025.106656.1293
Avishek Mazumder; Payeli Debbarma; Sk Sabir Rahaman; Susmita Chakraborty Das. "Efficacy and safety of Amlodipine with Torsemide in CKD with hypertension in tertiary care hospital: A prospective observational study". سامانه مدیریت نشریات علمی, 11, 3, 1404, -. doi: 10.30476/tips.2025.106656.1293
Mazumder, Avishek, Debbarma, Payeli, Rahaman, Sk Sabir, Chakraborty Das, Susmita. (1404). 'Efficacy and safety of Amlodipine with Torsemide in CKD with hypertension in tertiary care hospital: A prospective observational study', سامانه مدیریت نشریات علمی, 11(3), pp. -. doi: 10.30476/tips.2025.106656.1293
Mazumder, Avishek, Debbarma, Payeli, Rahaman, Sk Sabir, Chakraborty Das, Susmita. Efficacy and safety of Amlodipine with Torsemide in CKD with hypertension in tertiary care hospital: A prospective observational study. سامانه مدیریت نشریات علمی, 1404; 11(3): -. doi: 10.30476/tips.2025.106656.1293

Efficacy and safety of Amlodipine with Torsemide in CKD with hypertension in tertiary care hospital: A prospective observational study

Trends in Pharmaceutical Sciences and Technologies
دوره 11، شماره 3، آذر 2025
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2025.106656.1293
نویسندگان
Avishek Mazumder1؛ Payeli Debbarma1؛ Sk Sabir Rahaman* 2؛ Susmita Chakraborty Das1
1Department of Pharmacology, Calcutta National Medical College, Kolkata, India
2Department of Pharmacology, Prafulla Chandra Sen Government Medical College, Arambagh, Hooghly India
چکیده
Introduction:
Managing hypertension in chronic kidney disease (CKD) patients remains challenging, especially in resource-constrained settings like India where comorbidities are prevalent. Combining amlodipine, a calcium channel blocker, with torsemide, a long-acting loop diuretic, may enhance blood pressure control while preserving renal function.
Objectives:
To assess the efficacy and safety of amlodipine–torsemide combination therapy in controlling blood pressure and maintaining renal function among hypertensive CKD patients.
Methods:
This prospective, observational study was conducted over 12 months at a tertiary care hospital in Kolkata. A total of 104 adult CKD patients with uncontrolled hypertension were enrolled and initiated on a fixed or free combination of amlodipine and torsemide. Follow-up evaluations were performed at 3, 6, and 12 months. The primary outcome was change in systolic (SBP) and diastolic blood pressure (DBP). Secondary outcomes included renal function (serum creatinine, eGFR), electrolyte levels, and incidence of adverse drug reactions (ADRs).
Results:
Significant reductions in blood pressure were observed over 12 months (SBP: 156.7 ± 12.3 to 134.5 ± 9.1 mmHg; DBP: 92.6 ± 7.4 to 80.2 ± 6.8 mmHg; p < 0.001). Blood pressure control was achieved in over 67% of patients. Renal parameters remained stable, with no significant change in eGFR or serum creatinine. Electrolyte imbalances were minimal and ADRs were infrequent. Non-diabetic patients showed comparatively better renal outcomes.
Conclusion:
Amlodipine–torsemide combination therapy appears to be effective and well-tolerated for hypertension management in CKD patients, offering a viable alternative when RAAS inhibitors are unsuitable. Further head-to head randomized clinical trials are recommended.
کلیدواژه‌ها
Chronic kidney disease؛ hypertension؛ amlodipine؛ torsemide؛ combination therapy؛ blood pressure control
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